Global Environmental Flow Information for the Sustainable Development Goals

Environmental flows (EF) are an important component of Goal 6 (the ‘water goal’) of the Sustainable Development Goals (SDGs). Yet, many countries still do not have well-defined criteria on how to define EF. In this study, we bring together the International Water Management Institute’s (IWMI’s) expertise and previous research in this area to develop a new methodology to quantify EF at a global scale. EF are developed for grids (0.1 degree spatial resolution) for different levels of health (defined as environmental management classes [EMCs]) of river sections. Additionally, EF have been separated into surface water and groundwater components, which also helps in developing sustainable groundwater abstraction (SGWA) limits. An online tool has been developed to calculate EF and SGWA in any area of interest

Stabilization of myeloid-derived HIFs promotes vascular regeneration in retinal ischemia

The retinal vasculature is tightly organized in a structure that provides for the high metabolic demand of neurons while minimizing interference with incident light. The adverse impact of retinal vascular insufficiency is mitigated by adaptive vascular regeneration but exacerbated by pathological neovascularization. Aberrant growth of neovessels in the retina is responsible for impairment of sight in common blinding disorders including retinopathy of prematurity, proliferative diabetic retinopathy, and age-related macular degeneration. Myeloid cells are key players in this process, with diverse roles that can either promote or protect against ocular neovascularization. We have previously demonstrated that myeloid-derived VEGF, HIF1, and HIF2 are not essential for pathological retinal neovascularization. Here, however, we show by cell-specific depletion of Vhl in a mouse model of retinal ischemia (oxygen-induced retinopathy, OIR) that myeloid-derived HIFs promote VEGF and bFGF expression and enhance vascular regeneration in association with improved density and organization of the astrocytic network

Evaluating Sustainable Options for Valorization of Rice By-Products in Sri Lanka: An Approach for a Circular Business Model

Due to the significant quantities of waste generated by the Sri Lankan rice industry, circular bioeconomy methodologies were applied to examine value-adding entrepreneurial activities for rice industry by-products (RIB). The study was conceived after scouring the existing literature on agricultural waste management and interviewing experts in the field and the rice industry. In the first phase, the suitability of valorizing alternatives for RIB was considered via a multi-criteria decision-making method. Valorization options, such as biochar production, energy purposes, composting, and other activities, were evaluated using an analytical hierarchy process (AHP) based on four criteria, namely environmental, social, technical, and economic issues. The results indicated that the highest priority should be given to environmental, social, and economic considerations, with local priority vectors of 0.5887, 0.2552, and 0.0955, respectively. It was found that biochar production is the optimal valorization strategy for managing RIB in Sri Lanka. From these findings, the development of a sustainable business model for making biochar out of RIB was done based on commercial motivations and value addition in biochar manufacturing processes. The Business Model Canvas elements played a vital role in categorizing and interpreting the case study data. Though the RIB seems undervalued at present, it was found that as a direct result of environmental concerns, several stakeholders have developed RIB valorization with an emphasis on bioenergy generation and biochar production. Adequate subsidies (technology and knowledge), standard regulations, more collective actions for creating economies of scale, and marketing strategies (consumer awareness) are all necessary for the successful implementation of sustainable circular business models