29 research outputs found
Een patient met gecompliceerd verlopende shigellose
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4436.pdf (publisher's version ) (Open Access
Treatment of invasive aspergillosis with itraconazole in a patient with chronic granulomatous disease
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Protection of neutropenic mice from lethal Candida albicans infection by recombinant interleukin-1
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Biological and biochemical characterization of clinical isolates of herpes simplex virus type 2 resistant to acyclovir
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The efficacy of itraconazole against systemic fungal infections in neutropenic patients : a randomised comparative study with amphotericin B
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4533.pdf (publisher's version ) (Open Access
Risk factors for fluoroquinolone-resistant Escherichia coli in adults with community-onset febrile urinary tract infection
Objectives To assess risk factors for fluoroquinolone resistance in community-onset febrile Escherichia coli urinary tract infection (UTI). Methods A nested case-control study within a cohort of consecutive adults with febrile UTI presenting at primary healthcare centres or emergency departments during January 2004 through December 2009. Resistance was defined using EUCAST criteria (ciprofloxacin MIC >1.0 mg/L). Cases were subjects with fluoroquinolone-resistant E. coli, and controls those with fluoroquinolone-susceptible isolates. Multivariable logistic regression analysis was used to identify potential risk factors for fluoroquinolone resistance. Results Of 787 consecutive patients, 420 had E. coli-positive urine cultures. Of these, 51 (12%) were fluoroquinolone resistant. Independent risk factors for fluoroquinolone resistance were urinary catheter [odds ratio (OR) 3.1; 95% confidence interval (CI) 0.9-11.6], recent hospitalization (OR 2.0; 95% CI 1.0-4.3) and fluoroquinolone use in the past 6 months (OR 17.5; 95% CI 6.0-50.7). Environmental factors (e.g. contact with animals or hospitalized household members) were not associated with fluoroquinolone resistance. Of fluoroquinolone-resistant strains, 33% were resistant to amoxicillin/clavulanate and 65% to trimethoprim/sulfamethoxazole; 14% were extended-spectrum β-lactamase (ESBL) positive compared with <1% of fluoroquinolone-susceptible isolates. Conclusions Recent hospitalization, urinary catheter and fluoroquinolone use in the past 6 months were independent risk factors for fluoroquinolone resistance in community-onset febrile E. coli UTI. Contact with animals or hospitalized household members was not associated with fluoroquinolone resistance. Fluoroquinolone resistance may be a marker of broader resistance, including ESBL positivity.Immunogenetics and cellular immunology of bacterial infectious disease
Biomarker guided triage can reduce hospitalization rate in community acquired febrile urinary tract infection
Immunogenetics and cellular immunology of bacterial infectious disease
Behandeling en profylaxe van gegeneraliseerde mycosen
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21566___.PDF (publisher's version ) (Open Access
Schimmelinfecties bij patiënten met een gestoorde afweer
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21104___.PDF (publisher's version ) (Open Access
[Invasive zygomycosis: notably in diabetes mellitus and iron overload],Invasieve zygomycose: vooral bij diabetes mellitus en ijzerstapeling
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53342.pdf (publisher's version ) (Closed access