The megaproject sponsor as leader

CITATION: Louw, W., et al. 2018. The megaproject sponsor as leader. South African Journal of Industrial Engineering, 29(3):173-187, doi:10.7166/29-3-2058.The original publication is available at http://sajie.journals.ac.zaENGLISH ABSTRACT: The importance of the sponsor role, including its contribution to the success or failure of a project, is widely recognised in the project management literature. References to the sponsor’s leadership, and the substantial component it represents in the profile of the sponsor, are equally prevalent in the literature reviewed. A megaproject is a large-scale, complex venture that typically costs US$1 billion or more, takes many years to develop and build, involves multiple public and private stakeholders, is transformational, and influences millions of people. Executive sponsors are primarily allocated to projects of strategic importance that are complex, carry a considerable degree of risk, and are very visible. A megaproject is thus entitled to a sponsor from the executive (most senior) ranks within an organisation. Rather than joining the debates on complexity and leadership in the project management literature, this paper explains how leadership theories are used to identify instruments that can assist in the assessment of the leadership style and traits/attributes of a sponsor. A framework is then proposed to identify assessment instruments to evaluate the leadership style and leader traits/attributes of a project sponsor.AFRIKAANSE OPSOMMING: Die belangrikheid van die rol van die bestuursborg, insluitend die bydrae wat hy/sy maak tot die sukses of faling van ’n projek word wyd erken in die projekbestuur literatuur. Verwysings na die leierskapsrol van die bestuursborg asook die wesenlike komponent wat dit uitmaak van die profiel van die bestuursborg word bykans net soveel aangetref in die literatuur. ’n Megaprojek word gedefinieer as ’n grootskaalse, komplekse onderneming wat tipies 1 miljard Amerikaanse dollar of meer kos, etlike jare neem om te ontwikkel en te bou, veelvuldige publieke en privaat belanghebbendes betrek, transformasioneel van aard is, en miljoene mense beïnvloed. Uitvoerende bestuursborge word hoofsaaklik aangewys vir projekte van strategiese aard wat kompleks is, ’n beduidende hoeveelheid risiko dra, en uitsonderlik sigbaar is. Dit is dus duidelik dat ’n megaprojek geregtig is op ’n bestuursborg vanuit die uitvoerende en mees senior bestuursvlakke van ’n organisasie. Eerder as om aan te sluit by die debatte oor kompleksiteit en leierskap in die projekbestuur literatuur, dui hierdie artikel aan tot welke mate leierskapsteorieë benut kan word om instrumente te identifiseer wat kan meehelp in die evaluering van leierskapstyle asook die leierskap eienskappe/ attribute van ’n bestuursborg. Ter afsluiting word ’n raamwerk voorgestel om assesseringsinstrumente te identifiseer vir die evaluering van leierskapstyle en leier eienskappe/ attribute.http://sajie.journals.ac.za/pub/article/view/2058Publisher's versio

Potential of miRNAs in Plasma Extracellular Vesicle for the Stratification of Prostate Cancer in a South African Population

Prostate cancer (PCa) is the most common cause of cancer death among African men. The analysis of microRNAs (miRNAs) in plasma extracellular vesicles (EVs) can be utilized as a non-invasive tool for the diagnosis of PCa. In this study, we used small RNA sequencing to profile miRNAs cargo in plasma EVs from South African PCa patients. We evaluated the differential expression of miRNAs between low and high Gleason scores in the plasma EVs of South African patients and in the prostatic tissue from data available in the Cancer Genome Atlas (TCGA) Data Portal. We identified 7 miRNAs differently expressed in both EVs and prostatic tissues. We evaluated their expression using qPCR in a larger cohort of 10 patients with benign prostatic hyperplasia (BPH) and 24 patients with PCa. Here, we reported that the ratio between two of these miRNAs (i.e., miR-194-5p/miR-16-5p) showed a higher concentration in PCa compared to BPH and in metastatic PCa compared to localized PCa. We explored for the first time the profiling of miRNAs cargo in plasma EVs as a tool for the identification of putative markers in the South African population. Our finding indicated the ratio miR-194-5p/miR-16-5p as a non-invasive marker for the evaluation of PCa aggressiveness in this population

Effect of low energy diet for eight weeks to adults with overweight or obesity on folate, retinol, vitamin B₁₂, D and e status and the degree of inflammation: a post hoc analysis of a randomized intervention trial

Abstract Background Obesity is associated with vitamin insufficiency and low grade inflammation. The purpose of this study was to investigate the effect of weight loss on folate, retinol, vitamin B12, D and E status and the degree of inflammation. Methods Out of 110, 85 individuals (75% women) aged 39 ± 11 years with a mean ± SD BMI of 33 ± 4 kg/m2, completed an eight-week low energy diet (LED). Serum concentration of folate, retinol, B12, D and E and C-reactive protein and homocysteine (Hcy) were measured at baseline and at end of the LED. Results At baseline, 8% of the participants were deficient in folate, 13% in vitamin B12, 2% in retinol, 28% in vitamin D (72% were insufficient in vitamin D), and none were deficient in vitamin E. At baseline, BMI was inversely associated with retinol (P < 0.05) as was total and abdominal fat percentage with folate (P < 0.05); further BMI and measures of adiposity were positively associated with CRP (P < 0.01) and Hcy (P < 0.05). Homocysteine was inversely associated with all vitamins but retinol (P < 0.001). After the LED, the participants lost a mean [95% confidence intervals] of 12.3 [− 13.1,-11.6] kg. The serum concentration of folate, vitamin B12 and D were increased (P < 0.001) after the LED whereas the concentration of retinol and vitamin E were reduced (P < 0.001). Conclusion Eight-weeks LED resulted in 13% weight loss and an increase in the serum concentrations of folate, vitamin B12 and D. Baseline adiposity was inversely associated with folate and retinol, and positively associated with markers of inflammation. Trial registration Ethical Committee of Copenhagen as no. H-4-2013-135, NCT01561131

Detection of Cancer-Associated Gene Mutations in Urinary Cell-Free DNA among Prostate Cancer Patients in South Africa

Prostate cancer (PCa) is the most common cause of cancer death among African men. The presence of tumor-specific variations in cell-free DNA (cfDNA), such as mutations, microsatellite instability, and DNA methylation, has been explored as a source of biomarkers for cancer diagnosis. In this study, we investigated the diagnostic role of cfDNA among South African PCa patients. We performed whole exome sequencing (WES) of urinary cfDNA. We identified a novel panel of 31 significantly deregulated somatic mutated genes between PCa and benign prostatic hyperplasia (BPH). Additionally, we performed whole-genome sequencing (WGS) on matching PCa and normal prostate tissue in an independent PCa cohort from South Africa. Our results suggest that the mutations are of germline origin as they were also found in the normal prostate tissue. In conclusion, our study contributes to the knowledge of cfDNA as a biomarker for diagnosing PCa in the South African population

The production of nominal and verbal inflection in an agglutinative language: evidence from Hungarian

The contrast between regular and irregular inflectional morphology has been useful in investigating the functional and neural architecture of language. However, most studies have examined the regular/irregular distinction in non-agglutinative Indo-European languages (primarily English) with relatively simple morphology. Additionally, the majority of research has focused on verbal rather than nominal inflectional morphology. The present study attempts to address these gaps by introducing both plural and past tense production tasks in Hungarian, an agglutinative non-Indo-European language with complex morphology. Here we report results on these tasks from healthy Hungarian native-speaking adults, in whom we examine regular and irregular nominal and verbal inflection in a within-subjects design. Regular and irregular nouns and verbs were stem on frequency, word length and phonological structure, and both accuracy and response times were acquired. The results revealed that the regular/irregular contrast yields similar patterns in Hungarian, for both nominal and verbal inflection, as in previous studies of non-agglutinative Indo-European languages: the production of irregular inflected forms was both less accurate and slower than of regular forms, both for plural and past-tense inflection. The results replicate and extend previous findings to an agglutinative language with complex morphology. Together with previous studies, the evidence suggests that the regular/irregular distinction yields a basic behavioral pattern that holds across language families and linguistic typologies. Finally, the study sets the stage for further research examining the neurocognitive substrates of regular and irregular morphology in an agglutinative non-Indo-European language