Cytogerontology since 1881: A reappraisal of August Weismann and a review of modern progress

Cytogerontology, the science of cellular ageing, originated in 1881 with the prediction by August Weismann that the somatic cells of higher animals have limited division potential. Weismann's prediction was derived by considering the role of natural selection in regulating the duration of an organism's life. For various reasons, Weismann's ideas on ageing fell into neglect following his death in 1914, and cytogerontology has only reappeared as a major research area following the demonstration by Hayflick and Moorhead in the early 1960s that diploid human fibroblasts are restricted to a finite number of divisions in vitro. In this review we give a detailed account of Weismann's theory, and we reveal that his ideas were both more extensive in their scope and more pertinent to current research than is generally recognised. We also appraise the progress which has been made over the past hundred years in investigating the causes of ageing, with particular emphasis being given to (i) the evolution of ageing, and (ii) ageing at the cellular level. We critically assess the current state of knowledge in these areas and recommend a series of points as primary targets for future research

Data from: Ecosystem-scale impacts of non-timber forest product harvesting: effects on soil nutrients

1. The harvesting of non-timber forest products (NTFPs) is a global phenomenon, the sustainability of which has been studied for many species at the individual and population level. However, the broader scale impacts of NTFP harvesting have been acknowledged but rarely examined. 2. We assessed plant size and the soil attributes undercanopy and in the open, in replicate, paired harvested and non-harvested sites for three NTFPs differing in the extent of biomass removed, i.e. timber for firewood from a tree (Acacia karroo), fruits from a cactus (Opunita ficus-indica) and flowering culms from a grass (Cymbopogon marginatus). Soil variables tested included pH, resistivity, P, total N, nitrate nitrogen, ammonium nitrogen, K, Na, Ca and Mg. 3. The extent of loss of soil nutrients decreased across the three NTFPs relative to the proportion of biomass removed. Thus, significant differences in more soil variables were evident for the firewood species, least for the fruit species and intermediate for the grass species. Lower soil pH, P, C and K were evident in soils collected underneath A. karroo, whilst losses in cations of Na, Ca and Mg were reported in soils underneath C. marginatus, and only NO3N losses were recorded underneath O. ficus-indica. 4. Synthesis and applications. Our study reveals that whilst non-timber forest product (NTFP) harvesting may affect soil nutrients, this is not uniform between species and is likely to be a function of the extent of biomass removed and harvesting frequency. This indicates the need for caution in generalisations about the ecosystem-level impacts of NTFP harvesting as well as a concerted effort to better understand impacts at a greater range of scales than has been the case to date.09-Feb-201

Palaeolimnological evidence for the independent evolution of neighbouring terminal lakes the Murray Darling Basin Australia

The estuary of the lower River Murray features a complex mosaic of lakes, coastal lagoons and interconnecting channels. The waters of these wetlands are degraded as a result of river regulation, water abstraction, salinisation, sedimentation and the recent constriction of the River mouth. Palaeolimnologial analysis of sediment cores in two wetlands reveals that salinity in the large terminal Lake Alexandrina was only moderately influenced by tidal inflow, particularly over the past ca. 2000 years. It is now largely fresh as a result of isolation by a series of barriers completed by 1940 AD. In contrast, the seaward portion of the Coorong, a back barrier coastal lagoon, was determined to be a subsaline estuary strongly influenced by marine inflows. These findings contrast somewhat with the Coorong’s current Ramsar classification as a saline lagoon. Riverine diatoms, typical of the fossil flora of Lake Alexandrina, are rare or absent in the Holocene sediments of the Coorong, other than for a short period in the late Holocene in the northernmost end of the lagoon. The palaeolimnological evidence for independent evolution of these wetlands is consistent with geomorphic evidence of a stranded, last interglacial shoreline that acted as a sill limiting the exchange of flows between Lake Alexandrina and the Coorong lagoon.Jennie Fluin, Peter Gell, Deborah Haynes, John Tibby and Gary Hancoc