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Mycobacterial load assay

Tuberculosis is a difficult disease to treat, a process made more harder as tools to monitor treatment response only provide a result long after the patient has provided a sample. The mycobacterial load assay (MBLA) provides a simple molecular test to quantify and determine the viability of M. tuberculosis in human or other samples.Postprin

Measurement and Analysis of Wing and Tail Buffeting Loads on a Fighter Airplane

The buffeting loads measured on the wing and tail of a fighter airplane during 194 maneuvers are given in tabular form, along with the associated flight conditions. Measurements were made at altitudes of 30,000 to 10,000 feet and at speeds up to a Mach number of 0.8. Least-squares methods have been used for a preliminary analysis of the data. The agreement between the results of this analysis and the loads measured in stalls is sufficiently good to suggest the examination of the buffeting of other airplanes on the same basis

OMNIgene.SPUTUM suppresses contaminants whilst maintaining Mycobacterium tuberculosis viability and obviates cold-chain transport

The study was funded by DNA Genotek Inc. Canada, the manufacturer of OMNIgene.SPUTUM (grant number SMD0-Z0B014).Tuberculosis (TB) diagnostics are centralised, requiring long-distance transportation of specimens in most resource-limited settings. We evaluated the ability of OMNIgene.SPUTUM (OM-S) to obviate cold-chain transport of TB specimens. A two-arm (same-day and after 5 days sample processing) study was conducted to assess contamination rates and Mycobacterium tuberculosis viability in OM-S-treated samples against the standard decontamination procedure (SDP) in Mozambique, using Lowenstein Jensen (LJ) and mycobacterial growth indicator tube (MGIT) culture and molecular bacterial load assay. 270 specimens were processed using OM-S and SDP in same-day and 5-day arms. Contamination was lower in OM-S-treated than SDP-treated cultures: 12% versus 15% and 2% versus 27% in the same-day and 5-day arms, respectively. M. tuberculosis recovery in OM-S-treated LJ cultures was 10% and 56% higher in the same-day and 5-day arms, respectively, than SDP-treated cultures, but lower in MGIT (52% and 28% lower in the same-day and 5-day arms, respectively). M. tuberculosis viable count was 1log estimated CFU·mL−1 lower in 5-day OM-S-treated sputa. OM-S was more effective at liquefying sputum with a shorter sample processing time: 22 min for culture. OM-S is simple to use and has demonstrated a high potency to suppress contaminants, maintenance of viability at ambient temperatures and higher M. tuberculosis recovery, particularly in the solid LJ cultures. Optimisation of OM-S to achieve higher MGIT culture positivity and shorter time to result will increase its application and utility in the clinical management of TB.Publisher PDFPeer reviewe

Calibration of strain-gage installations in aircraft structures for the measurement of flight loads

A general method has been developed for calibrating strain-gage installations in aircraft structures, which permits the measurement in flight of the shear or lift, the bending moment, and the torque or pitching moment on the principal lifting or control surfaces. Although the stress in structural members may not be a simple function of the three loads of interest, a straightforward procedure is given for numerically combining the outputs of several bridges in such a way that the loads may be obtained. Extensions of the basic procedure by means of electrical combination of the strain-gage bridges are described which permit compromises between strain-gage installation time, availability of recording instruments, and data reduction time. The basic principles of strain-gage calibration procedures are illustrated by reference to the data for two aircraft structures of typical construction, one a straight and the other a swept horizontal stabilizer