PO-282 Effects Of Irises On Exercise To Improve Obesity

Objective Iirisin is a protein encoded by the target gene FNDC5 of peroxisome proliferator-activated receptor gamma coactivator in skeletal muscle. The secretory protein produced by shearing modification can promote the transformation of subcutaneous white fat into brown fat. As a kind of exercise-mediated muscle factor and potential fat factor, Irisin is closely related to obesity, insulin resistance, glucose and lipid metabolism, metabolic syndrome and so on. As an important preventive and therapeutic means of obesity, exercise plays a role in affecting irisin? Through the analysis of the effect of irisin on exercise intervention in obesity, this paper aims to lay a theoretical foundation for irisin to become a new way of thinking and a new target of treatment of obesity. Methods A computer-based search of the literature on "Research Progress in the Effects of Irisin on Exercise-induced Obesity" was conducted in the Sportdiscussussussand CNKI databases from 2012 to 2017. The key words were "obesity; exercise; Irisin; brown fat". Inclusion criteria were original research, Meta analysis and systematic review. Exclusion criteria: repetitive studies. A total of 86 articles were included in the review. Results (1) exercise can significantly improve obesity, insulin resistance, metabolic syndrome and other diseases;(2) Irisin can induce white fat Browning, increase body heat production, reduce body weight, and promote the expression of UCP1 by p38MAPK/ERK signaling pathway. Exogenous Irisin can significantly reduce obesity in mice induced by high-fat diet and improve insulin resistance.(3) whether it is one-time exercise or long-term exercise, endurance exercise or resistance exercise, moderate and low-intensity exercise or high-intensity exercise will increase the expression of irisin in skeletal muscle, blood or fat.However, the influence of different exercise intensity and different exercise modes on the expression of irisin is not regular, and the influence and mechanism of different exercise modes and exercise intensity on the expression of irisin between different species and different tissues have not been reported. Conclusions Exercise can significantly improve the occurrence and development of obesity, and the effect may be achieved by promoting the secretion and expression of irisin in skeletal muscle

The practice and perception of unexpected topic switching in Mandarin Chinese

Abstract In this paper, I combine a model of context, practice, and perception with a discursive-interactional approach to investigate the moral order of the practice and perception of unexpected topic switching in the context of everyday communication in mainland China, using data derived from recorded mundane conversations in Mandarin and playback with native Chinese speakers. Results show that the speakers initiate, react to, and perceive unexpected topic switching as a part of appropriate interactional norms. The analyst understandings, participant understandings, and metaparticipant understandings that I uncover indicate the influence of the sociocultural context, interactional context, and personal context on the practice and perception of unexpected topic switching

Effect of Doxorubicin Combined with Ipratropium Bromide on Pulmonary Function Indexes in the Treatment of Chronic Obstructive Pulmonary Disease

Objective: To observe the effect of different methods in the treatment of chronic obstructive pulmonary (COPD) disease. Methods: 86 COPD patients attending the clinic from 2020.7 to 2022.11 were divided into groups I and II according to the envelope method, 43 cases each were treated with theophylline extended-release tablets and group II was treated with ipratropium bromide, the lung function indexes of each group were tested and the total effective rate was calculated and compared between groups. Results: At the end of the treatment course, FEV1, FVC and FEV1/FVC levels in group II were higher than those in group I, and the difference reached a significant level (P < 0.05). The total effective rate in group I was 74.42%, which was lower than that in group II, which was 95.35%, forming a significant difference (P < 0.05). Conclusion: Treatment with doxorubicin combined with ipratropium bromide for those with COPD is effective and worthy of popular application

Research on Preference Polyhedron Model Based Evolutionary Multiobjective Optimization Method for Multilink Transmission Mechanism Conceptual Design

To make the optimal design of the multilink transmission mechanism applied in mechanical press, the intelligent optimization techniques are explored in this paper. A preference polyhedron model and new domination relationships evaluation methodology are proposed for the purpose of reaching balance among kinematic performance, dynamic performance, and other performances of the multilink transmission mechanism during the conceptual design phase. Based on the traditional evaluation index of single target of multicriteria design optimization, the robust metrics of the mechanism system and preference metrics of decision-maker are taken into consideration in this preference polyhedron model and reflected by geometrical characteristic of the model. At last, two optimized multilink transmission mechanisms are designed based on the proposed preference polyhedron model with different evolutionary algorithms, and the result verifies the validity of the proposed optimization method

Analysis of the application of methylprednisolone injection combined with ambroxol injection in the treatment of asthma

Objective: To observe the effectiveness of different medication regimens in the treatment of asthma diseases. Methods: Sixty-four patients with asthma who attended the medical records department from 2020.6 to 2022.8 were analyzed. 32 patients in group A were treated with methylprednisolone alone, while group B was treated with intravenous amiloride injection in addition to the medication regimen in group A. The improvement time of symptoms in each group was observed, the total effective rate was calculated and the differences between groups were analyzed. Results: In Group B, the improvement time of wheeze, cough, croup and wet rales was earlier than that in Group A (P＜0.05). In terms of total effective rate, the difference was 65.63% vs. 93.75% in group A vs. group B (P < 0.05). Conclusion: The combination of methylprednisolone and ambroxol injection in the treatment of asthma can provide more rapid relief of symptoms and improve the efficacy, which is worth promoting

An Investigation of the Efficacy of Glycine Theophylline Sodium Extended-Release Tablets in the Treatment of Bronchial Asthma

Objective: To observe the effect of treatment with theophylline extended-release tablets in patients with bronchial asthma. Methods: The medical records of 76 asthma patients admitted from 2020.8 to 2022.9 were extracted. 38 cases in the reference group received conventional basic treatment and 38 cases in the observation group received conventional + sodium theophylline glycinate treatment, and the condition control of the patients in the two groups was compared. Results: The patients in the observation group all disappeared from the disease symptoms earlier than the reference group (P < 0.05). In terms of total effective rate, the difference between the reference group and the observation group was 65.79% vs 92.11% (P < 0.05). Conclusion: Oral treatment with sodium theophylline glycinate is recommended for asthma patients to better control their condition

Application Study of Nebulized Low-Dose Azithromycin in the Treatment of Community-Acquired Pneumonia

Objective: To analyze the effect of nebulized low-dose azithromycin in the treatment of community-acquired pneumonia. Methods: The selected research subjects were 68 patients with community-acquired pneumonia admitted to our hospital from January 2020 to January 2021. The patients were divided into control group and experimental group by random number table method. The control group was treated with normal saline inhalation (34 cases), and the experimental group was treated with aerosol low-dose azithromycin (34 cases). The treatment effects of the two groups were compared. Results: There were significant differences in the effective rates of treatment between the two groups, and the experimental group was higher (P<0.05). There were significant differences in inflammatory cytokine indexes between the two groups, and the experimental group was lower (P<0.05). Conclusion: The treatment effect of low-dose azithromycin in the treatment of patients with community-acquired pneumonia is definite, and it can be applied and promoted in clinical practice