Objective: To observe the effect of different methods in the treatment of chronic obstructive pulmonary (COPD) disease. Methods: 86 COPD patients attending the clinic from 2020.7 to 2022.11 were divided into groups I and II according to the envelope method, 43 cases each were treated with theophylline extended-release tablets and group II was treated with ipratropium bromide, the lung function indexes of each group were tested and the total effective rate was calculated and compared between groups. Results: At the end of the treatment course, FEV1, FVC and FEV1/FVC levels in group II were higher than those in group I, and the difference reached a significant level (P < 0.05). The total effective rate in group I was 74.42%, which was lower than that in group II, which was 95.35%, forming a significant difference (P < 0.05). Conclusion: Treatment with doxorubicin combined with ipratropium bromide for those with COPD is effective and worthy of popular application