Objective: To analyze the effect of nebulized low-dose azithromycin in the treatment of community-acquired pneumonia. Methods: The selected research subjects were 68 patients with community-acquired pneumonia admitted to our hospital from January 2020 to January 2021. The patients were divided into control group and experimental group by random number table method. The control group was treated with normal saline inhalation (34 cases), and the experimental group was treated with aerosol low-dose azithromycin (34 cases). The treatment effects of the two groups were compared. Results: There were significant differences in the effective rates of treatment between the two groups, and the experimental group was higher (P<0.05). There were significant differences in inflammatory cytokine indexes between the two groups, and the experimental group was lower (P<0.05). Conclusion: The treatment effect of low-dose azithromycin in the treatment of patients with community-acquired pneumonia is definite, and it can be applied and promoted in clinical practice