418 research outputs found
Formulation of linguistic regression model based on natural words
When human experts express their ideas and thoughts, human words are basically employed in these expressions. That is, the experts with much professional experiences are capable of making assessment using their intuition and experiences. The measurements and interpretation of characteristics are taken with uncertainty, because most measured characteristics, analytical result, and field data can be interpreted only intuitively by experts. In such cases, judgments may be expressed using linguistic terms by experts. The difficulty in the direct measurement of certain characteristics makes the estimation of these characteristics imprecise. Such measurements may be dealt with the use of fuzzy set theory. As Professor L. A. Zadeh has placed the stress on the importance of the computation with words, fuzzy sets can take a central role in handling words [12, 13]. In this perspective fuzzy logic approach is offten thought as the main and only useful tool to deal with human words. In this paper we intend to present another approach to handle human words instead of fuzzy reasoning. That is, fuzzy regression analysis enables us treat the computation with words. In order to process linguistic variables, we define the vocabulary translation and vocabulary matching which convert linguistic expressions into membership functions on the interval [0–1] on the basis of a linguistic dictionary, and vice versa. We employ fuzzy regression analysis in order to deal with the assessment process of experts from linguistic variables of features and characteristics of an objective into the linguistic expression of the total assessment. The presented process consists of four portions: (1) vocabulary translation, (2) estimation, (3) vocabulary matching and (4) dictionary. We employed fuzzy quantification theory type 2 for estimating the total assessment in terms of linguistic structural attributes which are obtained from an expert
Genetic Changes to a Transcriptional Silencer Element Confers Phenotypic Diversity within and between Drosophila Species
The modification of transcriptional regulation has become increasingly appreciated as a major contributor to morphological evolution. However, the role of negative-acting control elements (e.g. silencers) in generating morphological diversity has been generally overlooked relative to positive-acting “enhancer” elements. The highly variable body coloration patterns among Drosophilid insects represents a powerful model system in which the molecular alterations that underlie phenotypic diversity can be defined. In a survey of pigment phenotypes among geographically disparate Japanese populations of Drosophila auraria, we discovered a remarkable degree of variation in male-specific abdominal coloration. In testing the expression patterns of the major pigment-producing enzymes, we found that phenotypes uniquely correlated with differences in the expression of ebony, a gene required for yellow-colored cuticle. Assays of ebony’s transcriptional control region indicated that a lightly pigmented strain harbored cis-regulatory mutations that caused correlated changes in its expression. Through a series of chimeric reporter constructs between light and dark strain alleles, we localized function-altering mutations to a conserved silencer that mediates a male-specific pattern of ebony repression. This suggests that the light allele was derived through the loss of this silencer’s activity. Furthermore, examination of the ebony gene of D. serrata, a close relative of D. auraria which secondarily lost male-specific pigmentation revealed the parallel loss of this silencer element. These results demonstrate how loss-of-function mutations in a silencer element resulted in increased gene expression. We propose that the mutational inactivation of silencer elements may represent a favored path to evolve gene expression, impacting morphological traits
Genetic Changes to a Transcriptional Silencer Element Confers Phenotypic Diversity within and between Drosophila Species
The modification of transcriptional regulation has become increasingly appreciated as a major contributor to morphological evolution. However, the role of negative-acting control elements (e.g. silencers) in generating morphological diversity has been generally overlooked relative to positive-acting “enhancer” elements. The highly variable body coloration patterns among Drosophilid insects represents a powerful model system in which the molecular alterations that underlie phenotypic diversity can be defined. In a survey of pigment phenotypes among geographically disparate Japanese populations of Drosophila auraria, we discovered a remarkable degree of variation in male-specific abdominal coloration. In testing the expression patterns of the major pigment-producing enzymes, we found that phenotypes uniquely correlated with differences in the expression of ebony, a gene required for yellow-colored cuticle. Assays of ebony’s transcriptional control region indicated that a lightly pigmented strain harbored cis-regulatory mutations that caused correlated changes in its expression. Through a series of chimeric reporter constructs between light and dark strain alleles, we localized function-altering mutations to a conserved silencer that mediates a male-specific pattern of ebony repression. This suggests that the light allele was derived through the loss of this silencer’s activity. Furthermore, examination of the ebony gene of D. serrata, a close relative of D. auraria which secondarily lost male-specific pigmentation revealed the parallel loss of this silencer element. These results demonstrate how loss-of-function mutations in a silencer element resulted in increased gene expression. We propose that the mutational inactivation of silencer elements may represent a favored path to evolve gene expression, impacting morphological traits
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Estimate of tsunami source using optimized unit sources and including dispersion effects during tsunami propagation: The 2012 Haida Gwaii earthquake
We apply a genetic algorithm (GA) to find the optimized unit sources using dispersive tsunami synthetics to estimate the tsunami source of the 2012 Haida Gwaii earthquake. The optimal number and distribution of unit sources gives the sea surface elevation similar to that from our previous slip distribution on a fault using tsunami data, but different from that using seismic data. The difference is possibly due to submarine mass failure in the source region. Dispersion effects during tsunami propagation reduce the maximum amplitudes by up to 20% of conventional linear long wave propagation model. Dispersion effects also increase tsunami travel time by approximately 1 min per 1,300 km on average. The dispersion effects on amplitudes depend on the azimuth from the tsunami source reflecting the directivity of tsunami source, while the effects on travel times depend only on the distance from the source.The sea bottom pressure data at the Ocean Bottom Seismograph stations used in this research were provided by instruments from the Ocean Bottom Seismograph Instrument Pool (http://www.obsip.org) which is funded by the US National Science Foundation. The facilities of the IRIS Data Management System were used to access the data used in this study. The sea level observations at the DART stations used in this research were provided by the National Oceanic and Atmospheric Administration and publicly available from http://nctr.pmel.noaa.gov/Dart/. The sea level observations at the tide gauge station in Canada were provided by the Canadian Hydrographic Service http://www.tides.gc.ca/eng. We thank Alexander Rabinovich (Institute of Ocean Sciences, Canada) for providing processed tide gauge data at the Canadian stations
Drosophila suzukii: the genetic footprint of a recent, world-wide invasion
Native to Asia, the soft-skinned fruit pest Drosophila suzukii has recently invaded the United States and Europe. The eastern United States represents the most recent expansion of their range, and presents an opportunity to test alternative models of colonization history. Here we investigate the genetic population structure of this invasive fruit fly, with a focus on the eastern United States. We sequenced six X-linked gene fragments from 246 individuals collected from a total of 12 populations. We examine patterns of genetic diversity within and between populations and explore alternative colonization scenarios using Approximate Bayesian Computation. Our results indicate high levels of nucleotide diversity in this species and suggest that the recent invasions of Europe and the continental United States are independent demographic events. More broadly speaking, our results highlight the importance of integrating population structure into demographic models, particularly when attempting to reconstruct invasion histories. Finally, our simulation results illustrate the general challenge of reconstructing invasion histories using genetic data and suggest that genome-level data are often required to distinguish among alternative demographic scenarios
Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4
Modelling the Effect of Temperature on Respiration Rate of Fresh Cut Papaya (Carica papaya L.) Fruits.
A respiration rate (RR) model based on Peleg’s equation was developed for predicting RRs of fresh cut papaya. Respiration data for fresh cut papaya at 3/4 maturity were generated at temperatures 5, 10, 15, 20, 25 and 30°C using a closed system. RRs was found to be significantly influenced by storage temperature and increased from 0.021 to 0.289 mL[O2]/kg·h and 0.063 to 0.393 mL[CO2]/kg·h as a function of O2 and CO2 gas concentrations, respectively. Peleg’s constant K 1 and K 2 were obtained from linear regression analysis using GraphPad Prism 5.0 software and regression coefficients have good fit with values close to unity. The model was verified to assess the capability of its predictability of the RRs over the temperatures. There was good agreement with the experimentally estimated RRs. Information derived from the model can contribute in the design of successful modified atmospheric systems for storage of fresh cut papaya
Geographical variations of the 0S0 normal mode amplitude: predictions and observations after the Sumatra-Andaman earthquake
Shelf life of fresh-cut spinach as affected by chemical treatment and type of packaging film
Association between Helicobacter pylori cagA-related genes and clinical outcomes in Colombia and Japan
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