Aiello

Aronoff

Azuma

Bose

C. Ebato

Chong

Cybulsky

Delgado

Dupre

Ebato

H. Goto

H. Watada

Izeboud

K. Azuma

Kobayashi

Kolterman

M. Arakawa

Mita

Mogi

Parkes

R. Kawamori

Ross

Shames

Szayna

T. Hirose

T. Mita

T. Nomiyama

Weber

Y. Fujitani

English

PubMed

Crossref

Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4

A long-acting glucagon-like peptide-1 analogue attenuates induction of plasminogen activator inhibitor type-1 and vascular adhesion molecules.

A major role for VCAM-1, but not ICAM-1, in early atherosclerosis.

A new en face method is useful to quantitate endothelial damage in vivo.

A simple method of isolating mouse aortic endothelial cells.

Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deﬁcient mice. Mol Cell

Ahre ´n B, Sjo ¨holm A. Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.

Atherosclerosis: an inﬂammatory disease.

Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet.

Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptordependent and -independent pathways. Circulation

Cutting edge: macrophage inhibition by cyclic AMP (cAMP): differential roles of protein kinase A and exchange protein directly activated by cAMP-1.

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Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats.

Exendin-4 normalized postcibal glycemic excursions in type 1 diabetes.

GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice.

Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury.

Go ¨ k eR ,G o ¨ke B. GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery.

HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia.

Impact of oxidative stress and peroxisome proliferator-activated receptor gamma coactivator-1alpha in hepatic insulin resistance.

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Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol

Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro.

Involvement of proton-sensing TDAG8 in extracellular acidiﬁcation-induced inhibition of proinﬂammatory cytokine production in peritoneal macrophages.

Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system.

Molecular mechanisms underlying cyclic AMP inhibition of macrophage dependent TNF-alpha production and neurotoxicity in response to amyloidogenic C-terminal fragment of Alzheimer’s amyloid precursor protein.

Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deﬁcient mice. Arterioscler Thromb Vasc Biol

Once daily injection of exendin-4 to diabetic mice achieves long-term beneﬁcial effects on blood glucose concentrations. Diabetologia

pharmacodynamics, and safety of exenatide in patients with type 2 diabetes mellitus.

Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy.

Suppression of tumor necrosis factor alpha production by cAMP in human monocytes: dissociation with mRNA level and independent of interleukin-10.

Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E-deﬁcient mice.

Synthetic exendin-4 (exenatide) signiﬁcantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes.

The betaadrenoceptor agonist clenbuterol is a potent inhibitor of the LPS-induced production of TNF-alpha and IL-6 in vitro and in vivo.

The neuropeptide vasoactive intestinal peptide generates tolerogenic dendritic cells.

The NR4A orphan nuclear receptor NOR1 is induced by platelet-derived growth factor and mediates

Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit nuclear factor-kappa B-dependent gene activation at multiple levels in the human monocytic cell line THP-1.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2844811

Inhibition of Monocyte Adhesion to Endothelial Cells and Attenuation of Atherosclerotic Lesion by a Glucagon-like Peptide-1 Receptor Agonist, Exendin-4

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