Study of space battery accelerated testing techniques. Phase 2 report - Ideal approaches towards accelerated tests and analysis of data

Ideal approaches to accelerated life tests and data analysis applied to space batterie

Yosemite Conference on Ionospheric Plasma in the Magnetosphere: Sources, Mechanisms and Consequences, meeting report

The sixth biennial Yosemite topical conference and the first as a Chapman Conference was held on February 3 to 6, 1986. Due to the recent changes in our perception of the dynamics of the ionospheric/magnetospheric system, it was deemed timely to bring researchers together to discuss and contrast the relative importance of solar versus terrestrial sources of magnetospheric plasma. Although the solar wind was once thought to dominate the supply of plasma in the Earth's magnetosphere, it is now thought that the Earth's ionosphere is a significant contributor. Polar wind and other large volume outflows of plasma have been seen at relatively high altitudes over the polar cap and are now being correlated with outflows found in the magnetotail. The auroral ion fountain and cleft ion fountain are examples of ionospheric sources of plasma in the magnetosphere, observed by the Dynamics Explorer 1 (DE 1) spacecraft. The conference was organized into six sessions: four consisting of prepared oral presentations, one poster session, and one session for open forum discussion. The first three oral sessions dealt separately with the three major topics of the conference, i.e., the sources, mechanisms, and consequences of ionospheric plasma in the magnetosphere. A special session of invited oral presentations was held to discuss extraterrestrial ionospheric/magnetospheric plasma processes. The poster session was extended over two evenings during which presenters discussed their papers on a one-on-one basis. The last session of the conferences was reserved for open discussions of those topics or ideas considered most interesting or controversial

Proceedings of the 1st Space Plasma Computer Analysis Network (SCAN) Workshop

The purpose of the workshop was to identify specific cooperative scientific study topics within the discipline of Ionosphere Magnetosphere Coupling processes and to develop methods and procedures to accomplish this cooperative research using SCAN facilities. Cooperative scientific research was initiated in the areas of polar cusp composition, O+ polar outflow, and magnetospheric boundary morphology studies and an approach using a common metafile structure was adopted to facilitate the exchange of data and plots between the various workshop participants. The advantages of in person versus remote workshops were discussed also

Acetylation of PAMAM dendrimers for cellular delivery of siRNA

<p>Abstract</p> <p>Background</p> <p>The advancement of gene silencing via RNA interference is limited by the lack of effective short interfering RNA (siRNA) delivery vectors. Rational design of polymeric carriers has been complicated by the fact that most chemical modifications affect multiple aspects of the delivery process. In this work, the extent of primary amine acetylation of generation 5 poly(amidoamine) (PAMAM) dendrimers was studied as a modification for the delivery of siRNA to U87 malignant glioma cells.</p> <p>Results</p> <p>PAMAM dendrimers were reacted with acetic anhydride to obtain controlled extents of primary amine acetylation. Acetylated dendrimers were complexed with siRNA, and physical properties of the complexes were studied. Dendrimers with up to 60% of primary amines acetylated formed ~200 nm complexes with siRNA. Increasing amine acetylation resulted in reduced polymer cytotoxicity to U87 cells, as well as enhanced dissociation of dendrimer/siRNA complexes. Acetylation of dendrimers reduced the cellular delivery of siRNA which correlated with a reduction in the buffering capacity of dendrimers upon amine acetylation. Confocal microscopy confirmed that escape from endosomes is a major barrier to siRNA delivery in this system.</p> <p>Conclusion</p> <p>Primary amine acetylation of PAMAM dendrimers reduced their cytotoxicity to U87 cells, and promoted the release of siRNA from dendrimer/siRNA complexes. A modest fraction (approximately 20%) of primary amines of PAMAM can be modified while maintaining the siRNA delivery efficiency of unmodified PAMAM, but higher degrees of amine neutralization reduced the gene silencing efficiency of PAMAM/siRNA delivery vectors.</p

DE 1 RIMS operational characteristics

The Retarding Ion Mass Spectrometer (RIMS) on the Dynamics Explorer 1 spacecraft observes both the thermal and superthermal (50 eV) ions of the ionosphere and inner magnetosphere. It is capable of measuring the detailed species distribution function of these ions in many cases. It was equipped with an integral electrometer to permit in-flight calibration of the detector sensitivities and variations thereof. A guide to understanding the RIMS data set is given. The reduction process from count rates to physical quantities is discussed in some detail. The procedure used to establish in-flight calibration is described, and results of a comparison with densities from plasma wave measurements are provided. Finally, a discussion is provided of various anomalies in the data set, including changes of channeltron efficiency with time, spin modulation of the axial sensor heads, apparent potential differences between the sensor heads, and failures of the radial head retarding potential sweep and of the -Z axial head aperture plane bias. Studies of the RIMS data set should be conducted only with a thorough awareness of the material presented here, or in collaboration with one of the scientists actively involved with RIMS data analysis

Particle tracking in a salinity gradient: A method for measuring sinking rate of individual phytoplankton in the laboratory

This paper presents a new method to measure the sinking rates of individual phytoplankton “particles” (cells, chains, colonies, and aggregates) in the laboratory. Conventional particle tracking and high resolution video imaging were used to measure particle sinking rates and particle size. The stabilizing force of a very mild linear salinity gradient (1 ppt over 15 cm) prevented the formation of convection currents in the laboratory settling chamber. Whereas bulk settling methods such as SETCOL provide a single value of sinking rate for a population, this method allows the measurement of sinking rate and particle size for a large number of individual particles or phytoplankton within a population. The method has applications where sinking rates vary within a population, or where sinking rate-size relationships are important. Preliminary data from experiments with both laboratory and field samples of marine phytoplankton are presented here to illustrate the use of the technique, its applications, and limitations. Whereas this paper deals only with sinking phytoplankton, the method is equally valid for positively buoyant species, as well as nonbiological particles

The cleft ion fountain

Low-energy (below approximately 50 eV) ionospheric ions, injected into the magnetosphere at the dayside cleft, are studied using data from the retarding ion mass spectrometer (RIMS) experiment on the Dynamics Explorer 1 satellite. It is concluded that upwelling ions at the cleft form an ion fountain and are blown into the polar cap by antisunward convection. At high Kp (>4), convection is generally strong enough to fill the entire polar magnetosphere with low-energy O+ ions, whereas at low kp (<2) they are largely restricted to the dayside half of the cap. Using a two-dimensional kinetic ion trajectory model, the locations where RIMS detected O+ within the cap are shown to be consistent with the spatial distributions of O+ density, predicted for an upwelling ion source at the cleft and various dawn-dusk convection electric fields. A detailed study is made of one polar pass of DE 1, during which RIMS detected He+, N+, O+, and O++ ions, the ion trajectory model being used to trace all these ions back to a common source at an observed upwelling ion event near the cleft. All observed species are deduced to be falling earthward in the nightside of the cap, as predicted from the model, indicating the dominance of gravity over upward field-aligned acceleration (such as by the ambipolar electric field). Comparison of field-aligned velocities observed for O+ and O++ ions defines a maximum limit to the upward electrostatic acceleration present within the cap which was only sufficient to eject ionospheric H+ ions, all heavier ions being supplied from the dayside by the cleft ion fountain

Faith, bordering and modern slavery: A UK case study

In this paper we consider the imbrication of UK immigration and border controls into support environments of the anti-modern slavery sphere. We draw on the findings of a 3.5 years ESRC-funded study to explore how the increasingly strident government anti-migrant agenda - broadly seen in the ‘hostile environment’, a culture of disbelief and an overarching preeminence of border controls over human rights protections - is percolating into care providers in the modern slavery sector. Bordering in this sector has not had the same level of scrutiny as within the asylum sector, yet is a particularly interesting site to explore due to the confluence of caring and control impulses. The fresh insight we bring to this context is a focus on the notable presence of faith-based organisations in this sphere. We consider the implications of the relationships between faith, support and bordering - both for those subjected to immigration controls, and those working inextricably within them to support individuals exiting exploitation

Three-phase four-leg flying-capacitor multi-level inverter-based active power filter for unbalanced current operation.

This study describes a new application of flying capacitor multi-level inverters whereby a three-phase, four-leg three-level inverter is used for harmonic current cancellation and unbalanced current compensation in a four-wire system. A direct three-dimensional-pulse-width modulation (3D-PWM) scheme is developed to deal with the increased state redundancy in the four-leg flying capacitor multi-level inverter. Test results show much superior performance in the four-leg case, which may allow the use of smaller DC supply capacitors. A new modified dead-beat current control algorithm is proposed and combined successfully with the 3D-PWM modulation technique in a hardware demonstrator of a complete active filter