The ways to improve the energy conversion efficiency in erbium-doped Gd 2 O 3 nanoparticles

The basic requirements for the crystal lattice and defectiveness of Gd 2 O 3 matrix as well as for the concentration of Er 3+ dopants to achieve the enhanced parameters of energy conversion in Gd 2 O 3 :Er nanoparticles are summarized. The obtained data allow to optimize and improve the functional characteristics of Gd 2 O 3 :Er-based down-conversion layers applying in solar cells. © 2018 Institute of Physics Publishing. All rights reserved.The work has been funded by the Ministry of Education and Science of the Russian Federation (Government task №3.1485.2017/4.6)

Professional satisfaction of prospects for the first year of independent pharmaceutical activity

The article considers the attitudes of graduates to the specialty of the pharmacist, describes the factors of motivation in choosing a profession, substantiates the sustainability of professional choice, and considers the satisfaction of graduates in the specialty and the quality of education at the universityВ статье рассмотрено отношения выпускников к специальности провизора, описаны факторы мотивации при выборе профессии, обоснована устойчивость профессионального выбора, а также рассмотрена удовлетворённость выпускников специальности качеством образования в университете

Prospects of implementing integrated information systems in the preferential drug provision of patients with copd on the territory of Sverdlovsk region

Analysis of prospects of implementation and functionality of information systems in preferential drug provision, a review of the regulatory framework in the system of preferential provision of medicines.Анализ перспективы внедрения и функциональных возможностей информационных систем в льготном лекарственном обеспечении, обзор нормативной базы в системе льготного лекарственного обеспечения

Modulation of host central carbon metabolism and in situ glucose uptake by intracellular Trypanosoma cruzi amastigotes.

Obligate intracellular pathogens satisfy their nutrient requirements by coupling to host metabolic processes, often modulating these pathways to facilitate access to key metabolites. Such metabolic dependencies represent potential targets for pathogen control, but remain largely uncharacterized for the intracellular protozoan parasite and causative agent of Chagas disease, Trypanosoma cruzi. Perturbations in host central carbon and energy metabolism have been reported in mammalian T. cruzi infection, with no information regarding the impact of host metabolic changes on the intracellular amastigote life stage. Here, we performed cell-based studies to elucidate the interplay between infection with intracellular T. cruzi amastigotes and host cellular energy metabolism. T. cruzi infection of non-phagocytic cells was characterized by increased glucose uptake into infected cells and increased mitochondrial respiration and mitochondrial biogenesis. While intracellular amastigote growth was unaffected by decreased host respiratory capacity, restriction of extracellular glucose impaired amastigote proliferation and sensitized parasites to further growth inhibition by 2-deoxyglucose. These observations led us to consider whether intracellular T. cruzi amastigotes utilize glucose directly as a substrate to fuel metabolism. Consistent with this prediction, isolated T. cruzi amastigotes transport extracellular glucose with kinetics similar to trypomastigotes, with subsequent metabolism as demonstrated in 13C-glucose labeling and substrate utilization assays. Metabolic labeling of T. cruzi-infected cells further demonstrated the ability of intracellular parasites to access host hexose pools in situ. These findings are consistent with a model in which intracellular T. cruzi amastigotes capitalize on the host metabolic response to parasite infection, including the increase in glucose uptake, to fuel their own metabolism and replication in the host cytosol. Our findings enrich current views regarding available carbon sources for intracellular T. cruzi amastigotes and underscore the metabolic flexibility of this pathogen, a feature predicted to underlie successful colonization of tissues with distinct metabolic profiles in the mammalian host

Telecollaboration for professional purposes: Towards developing a formal register in the German classroom

This study reports on the development of a professional spoken register among learners of German as they participate in four synchronous Web conferences with German-speaking professionals. The researchers investigated the effect of interaction with expert German speakers combined with an instructional intervention focusing on pragmatic competence on the development of learners’ ability to communicate in a second language (L2) professional register. The data reveal a positive effect on the strategic use of modal verbs for expressing polite requests as well as a moderate effect on learners’ use of the subjunctive mood to establish social distance. These results add further support for the use of intercultural online exchanges mediated by data-driven instruction in the foreign language classroom and highlight the utility of a microgenetic approach to analyzing spoken data