Globalization of the education space in EU countries and Great Britain through radical information reform

The article reveals the main principles of globalization of the educational space in the EU countries and Great Britain through radical information reformation. The action plan, which includes the six dimensions disclosed in the article, is of great importance from 2020 to 2025 for the formation of the European Education Area (European Education Area), in the conditions of the COVID-19 pandemic and for the development of innovativeness. Measures developed by the European Commission to achieve the specified dimensions are proposed (increasing and monitoring the quality of education; paying attention to gender sensitivity and inclusiveness in education; modernizing digital transformations in education, increasing the competence and motivation of specialists involved in the educational field). The importance and necessity for the education of distance learning programs based on educational models that are known all over the world (in the example of Great Britain) is shown. In the field of information, constant changes and improvements are taking place, leading to the emergence of a qualitatively new type of social system. The information society is the main and necessary in the educational space, therefore the article shows the basic prerequisites of technological, spatial, economic, cultural, and political approaches to the improvement of the information society

Relevance of the problem of acne among students of USMU Russia

Acne vulgaris is a widespread in the world population chronic inflammatory disease of hair follicles that has a genetic predisposition. Acne affects areas of the skin of visual localization, with the resolution of inflammatory elements formed long-term existing pink spots, areas of hyperpigmentation, as well as persistent scars of varying degrees of severity, which are cosmetic defects, are difficult to adjust and can significantly reduce thequality of life of patients. The article presents its own data on the study of the prevalence of manifestations of acne among students aged 18-23 years (n=171), assesses the impact of manifestations of acne on the quality of life of students and analyzes the degree of relevance of this problem among students. Modern methods of acne treatment are presented, as well as modern possibilities of cosmetological correction of acne and post-acne.Вульгарные угри (acnevulgaris) – распространенное в мировой популяции хроническое воспалительное заболевание сально-волосяных фолликулов, имеющее генетическую предрасположенность. Угревая болезнь поражает участки кожи визуальной локализации, при разрешении воспалительных элементов образуются длительно существующие розовые пятна, участки гиперпигментации, а также стойкие рубцы разной степени выраженности, которые являются косметическими дефектами, сложно корректируются и могут значительно снижать качество жизни больных. В статье представлены собственные данные по исследованию распространенности проявлений угревой болезни среди студентов УГМУ в возрасте от 18-23 лет (n=171), проведена оценка влияния проявлений угревой болезни на качество жизни студентов и проанализирована степень актуальности данной проблемы среди студентов. Представлены современные методы лечения угревой болезни, а также отражены современные возможности косметологической коррекции акне и постакне

Read-Across of 90-day Rat Oral Repeated-Dose Toxicity: A Case Study for Selected n-Alkanols

n-Alkanols provide an excellent example where a category-approach to read-across may be used to estimate the repeated-dose endpoint for a number of untested derivatives (target chemicals) using experimental data for tested derivatives (source chemicals). n-Alkanols are non-reactive and exhibit the unspecific, reversible simple anaesthesia or non-polar narcosis mode of toxic action in that the metabolic products of the parent alcohols do not contribute to the toxic endpoint evaluated. In this case study, the chemical category is limited to the readily bioavailable (C5 to C13) analogues. The toxicokinetic premise includes rapid absorption via the gastrointestinal tract, distribution in the circulatory system, and first-pass metabolism in the liver resulting in metabolism via oxidation to CO2 and with minor elimination of oxidative intermediate as glucuronides. Two analogues have experimental 90-day oral repeated-dose toxicity data which exhibit qualitative and quantitative consistency. Typical findings include decreased body weight, slightly increased liver weight which, in some cases, is accompanied by clinical chemical and haematological changes but generally without concurrent histopathological effects at the Lowest Observed Effect Level (LOEL). Chemical similarity between the analogues is readily defined by a variety of structure-related properties; data uncertainty associated with toxicokinetic and toxicodynamic similarities is low. Uncertainty associated with mechanistic relevance and completeness of the read-across is reduced by the concordance of in vivo and in vitro results, as well as high throughput and in silico methods data. As shown in detail, the 90-day oral repeated-dose toxicity No Observed Effect Level (NOEL) value of 1000 mg/kg bw/d for 1-pentanol and 1-hexanol based on LOEL of very low systemic toxicity can be read across to fill the data gaps of the untested analogues in this category with acceptable uncertainty