CARACTERIZACIÓN MECÁNICA Y MICROESTRUCTURAL DE UNIONES SOLDADAS DE ALUMINIO SERIE 6061 MEDIANTE EL MÉTODO DE SOLDADURA POR FRICCIÓN-AGITACIÓN (FSW)

La presente investigación aborda el tema del método de soldadura por fricción agitación FSW por su siglas en inglés (Friction-Stir Welding), en el cual la unión del metal se consigue en estado sólido y sin superar el punto de fusión, por lo tanto es un proceso empleado en su mayoría para unir metales y aleaciones que presenten baja soldabilidad por métodos de soldadura por fusión, como por ejemplo el aluminio el cual es utilizado en la industria aeronáutica, automotriz, naval, entre otras. En este tipo de soldadura la unión se produce por un efecto termomecanico causado por la fricción que se genera dado al contacto entre el metal base y una herramienta que rota y avanza a través de la junta, lo que produce un aporte de calor llevando el metal base a un estado plástico permitiendo la unión del mismo. Por lo tanto se busca evaluar el efecto de la variación de las velocidades de rotación y de avance, en uniones soldadas de Aluminio 6061, con el fin de identificar con que variables se obtiene las mejores condiciones en la soldadura, para lo cual se emplearon ensayos destructivos (de tensión, flexión y dureza) y análisis metalográfico

Deep Learning in Single-Cell Analysis

Single-cell technologies are revolutionizing the entire field of biology. The large volumes of data generated by single-cell technologies are high-dimensional, sparse, heterogeneous, and have complicated dependency structures, making analyses using conventional machine learning approaches challenging and impractical. In tackling these challenges, deep learning often demonstrates superior performance compared to traditional machine learning methods. In this work, we give a comprehensive survey on deep learning in single-cell analysis. We first introduce background on single-cell technologies and their development, as well as fundamental concepts of deep learning including the most popular deep architectures. We present an overview of the single-cell analytic pipeline pursued in research applications while noting divergences due to data sources or specific applications. We then review seven popular tasks spanning through different stages of the single-cell analysis pipeline, including multimodal integration, imputation, clustering, spatial domain identification, cell-type deconvolution, cell segmentation, and cell-type annotation. Under each task, we describe the most recent developments in classical and deep learning methods and discuss their advantages and disadvantages. Deep learning tools and benchmark datasets are also summarized for each task. Finally, we discuss the future directions and the most recent challenges. This survey will serve as a reference for biologists and computer scientists, encouraging collaborations.Comment: 77 pages, 11 figures, 15 tables, deep learning, single-cell analysi

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

Diseño de un sistema de televisión por cable en la Facultad de Ingeniería Mécanica y Eléctrica

Tesis (Maestro en Ciencias de la Ingeniería Eléctrica con Especialidad en Eléctronica) - Universidad Autónoma de Nuevo León, 2000UANLhttp://www.uanl.mx

Living alone : motivations, protective and risk factors in elderly

El envejecimiento de la población, los cambios culturales, así como las nuevas dinámicas y conformación de las familias, han llevado a que el número de ancianos que viven solos sea cada vez mayor. Vivir solo no es un problema para el anciano si cuenta con el soporte funcional, social, afectivo y cognitivo necesarios para poder evitar y afrontar los riesgos de n tener la compañía de otra persona. Sin embargo, no todos los ancianos que viven solos cuentan con los recursos necesarios para poder hacerlo. Algunos pueden presentar deterioro físico que impacta en su funcionalidad, otros pueden tener compromiso a nivel cognitivo o afectivo que los lleve al aislamiento; también puede haber quienes no cuenten con la red de apoyo social suficiente que les brinde asistencia en caso de ser necesario y otros no tienen los recursos económicos mínimos para solventar los gastos y necesidades básicas que implican el vivir solo. En el presente trabajo pretendemos hacer un resumen de las motivaciones, las condiciones que favorecen y los riesgos que pueden afrontar las personas ancianas que viven solas.Adultos mayoresThe aging of the population, cultural changes as well as new dynamics and conformation of families have led to growing numbers of elderly people who are living alone. Living alone is not a problem to older people as long as they have functional, social, affective and cognitive support necessary to be able to avoid and face the risks of living without the company of another person. However, not all older people living alone have enough resources to do so. Some may present physical deterioration that affects their functionality, others may have cognitive or affective impairment that can lead to isolation. !ere could also be those who do not have the social support to assists them if necessary and others do not have the economic minimum resource to cover the expenses and the necessities that imply to live alone. In the present work, we intend to summarize the motivations, the favorable conditions and the risks that can affect the elderly people living alone.Revista Nacional - Indexad

Matemática-CE101-201900

Este es un curso general que corresponde a la línea de matemática para las carreras de la Facultad de Negocios EPE es de carácter teórico-práctico y se dicta en la modalidad semipresencial (Blended); está dirigido a los estudiantes de primer ciclo; proporciona el soporte matemático al estudiante para las asignaturas siguientes propias de cada especialidad por tal razón los conceptos de cada tema se definen de forma sencilla relacionándolos con problemas afines a los negocios. El curso busca desarrollar la competencia general de razonamiento cuantitativo en el nivel 1 en las dimensiones de: interpretación representación cálculo análisis y comunicación o argumentación; aplicados a problemas sencillos de contexto real en los negocios con el propósito de que el estudiante sea capaz de trabajar con datos alfanuméricos representados de diferentes formas (tablas gráficos etc.) y utilizarlos como argumentos para sustentar una idea o tomar decisiones en base a esta información

Characterization and function of a sunflower (Helianthus annuus L.) Class II acyl-CoA-binding protein

5 Figuras.-- 2 TablasAcyl-CoA-binding proteins (ACBP) bind to long-chain acyl-CoA esters and phospholipids, enhancing the activity of different acyltransferases in animals and plants. Nevertheless, the role of these proteins in the synthesis of triacylglycerols (TAGs) remains unclear. Here, we cloned a cDNA encoding HaACBP1, a Class II ACBP from sunflower (Helianthus annuus), one of the world's most important oilseed crop plants. Transcriptome analysis of this gene revealed strong expression in developing seeds from 16 to 30 days after flowering. The recombinant protein (rHaACBP1) was expressed in Escherichia coli and purified to be studied by in vitro isothermal titration calorimetry and for phospholipid binding. Its high affinity for saturated palmitoyl-CoA (16:0-CoA; K 0.11 μM) and stearoyl-CoA (18:0-CoA; K 0.13 μM) esters suggests that rHaACBP1 could act in acyl-CoA transfer pathways that involve saturated acyl derivatives. Furthermore, rHaACBP1 also binds to both oleoyl-CoA (18:1-CoA; K 6.4 μM) and linoleoyl-CoA (18:2-CoA; K 21.4 μM) esters, the main acyl-CoA substrates used to synthesise the TAGs that accumulate in sunflower seeds. Interestingly, rHaACBP1 also appears to bind to different species of phosphatidylcholines (dioleoyl-PC and dilinoleoyl-PC), glycerolipids that are also involved in TAG synthesis, and while it interacts with dioleoyl-PA, this is less prominent than its binding to the PC derivative. Expression of rHaACBP in yeast alters its fatty acid composition, as well as the composition and size of the host acyl-CoA pool. These results suggest that HaACBP1 may potentially fulfil a role in the transport and trafficking of acyl-CoAs during sunflower seed development.We thank A. González-Callejas and M. Parra-Camacho for their skilful technical assistance. This work was funded by the MINECO and FEDER Project AGL2017-83449-R, the CSIC/RGC joint research award (Project 2011HK0008; S-HK006/12), and the Wilson and Amelia Wong Endowment Fund

Characterization of a small acyl-CoA-binding protein (ACBP) from Helianthus annuus L. and its binding affinities

33 Páginas; 7 Figuras; 2 TablasAcyl-CoA-binding proteins (ACBPs) bind to acyl-CoA esters and promote their interaction with other proteins, lipids and cell structures. Small class I ACBPs have been identified in different plants, such as Arabidopsis thaliana (AtACBP6), Brassica napus (BnACBP) and Oryza sativa (OsACBP1, OsACBP2, OsACBP3), and they are capable of binding to different acyl-CoA esters and phospholipids. Here we characterize HaACBP6, a class I ACBP expressed in sunflower (Helianthus annuus) tissues, studying the specificity of its corresponding recombinant HaACBP6 protein towards various acyl-CoA esters and phospholipids in vitro, particularly using isothermal titration calorimetry and protein phospholipid binding assays. This protein binds with high affinity to de novo synthetized derivatives palmitoly-CoA, stearoyl-CoA and oleoyl-CoA (Kd 0.29, 0.14 and 0.15 μM respectively). On the contrary, it showed lower affinity towards linoleoyl-CoA (Kd 5.6 μM). Moreover, rHaACBP6 binds to different phosphatidylcholine species (dipalmitoyl-PC, dioleoyl-PC and dilinoleoyl-PC), yet it displays no affinity towards other phospholipids like lyso-PC, phosphatidic acid and lysophosphatidic acid derivatives. In the light of these results, the possible involvement of this protein in sunflower oil synthesis is considered.This work was supported by the MINECO and FEDER (Project AGL2011-23187), a joint Consejo Superior de Investigaciones Cientificas/Research Grant Council of Hong Kong (CSIC/RGC) research award (Project 2011HK0008; S-HK006/12), and the Wilson and Amelia Wong Endowment Fund.Peer reviewe