5 research outputs found
Somatic cell count during and between milkings
The objectives of the study were to determine 1) how sampling time between milkings affects the sensitivity and specificity of somatic cell count (SCC) as an indicator for intramammary infection (IMI) status, and 2) which cells are responsible for the diurnal variation in SCC. Six Prince Edward Island, Canada, dairy herds were selected. Quarter samples for SCC were collected immediately before the a.m. milking (pre-a.m.), halfway through the a.m. milking, immediately after the a.m. milking, every 60 min after detachment of the milking unit, and immediately before the p.m. milking (pre-p.m.). Compared with the geometric mean SCC at the pre-a.m. milking, SCC of quarters with no IMI between milkings was higher up to 7 h after milking. The pre-p.m. SCC was significantly lower than the pre-a.m. SCC in quarters with no IMI. Specificity of SCC at a cutoff of 200,000 or 500,000 cells/mL as an indicator for IMI status declined substantially after the a.m. milking. In quarters with elevated SCC, the proportion of polymorphonuclear leukocytes was larger immediately after milking. For accurate interpretations of SCC tests—whether by a laboratory, portable SCC device, or the California Mastitis Test—veterinarians, researchers, and udder health advisors should take milk samples immediately before milking
Biology and nutrition of Spodoptera frugiperda (Lepidoptera: Noctuidae) fed on different food sources
A meta-analysis of Hodgkin lymphoma reveals 19p13.3 <i>TCF3</i> as a novel susceptibility locus
Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95% confidence interval (95% CI)=0.76–0.86, <i>P</i><sub>combined</sub>=3.5 × 10<sup>−10</sup>), located in intron 2 of <i>TCF3</i> (also known as <i>E2A</i>), a regulator of B- and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including <i>TCF3</i>, and HL risk
Квитанция по принятию объявление в газету "Вечернее Тбилиси"
Русудан Багратион-Мухранская - дочка Нико Бур