A Real-time Decision Support System Prototype for Management of a Power Block

This paper describes the basic tools for a real-time decision support system of a semiotic type on the example of the prototype for management and monitoring of a nuclear power block implemented on the basis of the tool complex G2+GDA using cognitive graphics and parallel processing. This work was supported by RFBR (project 02-07-90042)

Spherically averaged phased translation function and its application to the search for molecules and fragments in electron-density maps

Journal ArticleThe molecular-replacement method has been extended to locate molecules and their fragments in an electron-density map. The approach is based on a new spherically averaged phased translation function. The position of the centre of mass of a search model is found prior to determination of its orientation. The orientation is subsequently found by a phased rotation function. The technique also allows superposition of distantly related macromolecules. The method has been implemented in a computer program MOLREP and successfully tested using experimental data sets

Development and analysis of functional model of business process design of steam turbine plants on the example of the steam turbine department SBTt CJSC "The Ural Turbine Works"

Статья представляет собой анализ производственных и бизнес процессов ОПТ (отдела паровых турбин) ЗАО «Уральский турбинный завод». Целью анализа является создании функциональной модели типа «As-Is» и информационных связей системы проектирования паротурбинных установок.This article is an analysis of production and business processes of the DST (department of steam turbine), CJSC "The Ural Turbine Works". The purpose of the analysis is to create a functional model of the type "As-is" and information links system design of steam turbine plants

BALBES: a molecular-replacement pipeline

The fully automated pipeline, BALBES, integrates a redesigned hierarchical database of protein structures with their domains and multimeric organization, and solves molecular-replacement problems using only input X-ray and sequence data

To the question of research on hoisting equipment hydraulic drive dynamics by using it means in educational process

The program "Mobile Mining Hoisting Units Dynamics" has been developed. The programme proposed can be applied while teaching discipline "Dynamics of Mining Machines" to students of a master degree course in the direction 151000.68, also to those studying in specialty 130400.65 whose major is "Mining machinery and Equipment", "Electrification and automation of mining operations" in doing coursework and diploma projects on disciplines "Hydropneumatic electric drive" and "Dynamic Strength"Разработана программа «Динамика мобильных проходческих подъемных установок». Предложенная программа применима при изучении дисциплины «Динамика горных машин» для магистрантов, обучающихся по направлению 151000.68 «Технологические машины и оборудование» и студентов специальности 130400.65 специализаций «Горные машины и оборудование», «Электрификация и автоматизация горного производства» для выполнения курсового и дипломного проектирования по дисциплинам «Гидро- пневмо- электропривод» и «Динамика и прочность

JLigand: a graphical tool for the CCP4 template-restraint library

The CCP4 template-restraint library defines restraints for biopolymers, their modifications and ligands that are used in macromolecular structure refinement. JLigand is a graphical editor for generating descriptions of new ligands and covalent linkages

Laser in the axial electric field as a tool to search for P-, T- invariance violation

We consider rotation of polarization plane of the laser light when a gas laser is placed in a longitudinal electric field (10~kV/cm). It is shown that residual anisotropy of the laser cavity 10^{-6} and the sensitivity to the angle of polarization plane rotation about 10^{-11} -10^{-12} rad allows one to measure an electron EDM with the sensitivity about 10^{-30} e cm.Comment: 12 page

Linear theory of nonlocal transport in a magnetized plasma

A system of nonlocal electron-transport equations for small perturbations in a magnetized plasma is derived using the systematic closure procedure of V. Yu. Bychenkov et al., Phys. Rev. Lett. 75, 4405 (1995). Solution to the linearized kinetic equation with a Landau collision operator is obtained in the diffusive approximation. The Fourier components of the longitudinal, oblique, and transversal electron fluxes are found in an explicit form for quasistatic conditions in terms of the generalized forces: the gradients of density and temperature, and the electric field. The full set of nonlocal transport coefficients is given and discussed. Nonlocality of transport enhances electron fluxes across magnetic field above the values given by strongly collisional local theory. Dispersion and damping of magnetohydrodynamic waves in weakly collisional plasmas is discussed. Nonlocal transport theory is applied to the problem of temperature relaxation across the magnetic field in a laser hot spot.Comment: 27 pages, 13 figure

Cytoplasmic Compartmentalization of the Fetal piRNA Pathway in Mice

Derepression of transposable elements (TEs) in the course of epigenetic reprogramming of the mouse embryonic germline necessitates the existence of a robust defense that is comprised of PIWI/piRNA pathway and de novo DNA methylation machinery. To gain further insight into biogenesis and function of piRNAs, we studied the intracellular localization of piRNA pathway components and used the combination of genetic, molecular, and cell biological approaches to examine the performance of the piRNA pathway in germ cells of mice lacking Maelstrom (MAEL), an evolutionarily conserved protein implicated in transposon silencing in fruit flies and mice. Here we show that principal components of the fetal piRNA pathway, MILI and MIWI2 proteins, localize to two distinct types of germinal cytoplasmic granules and exhibit differential association with components of the mRNA degradation/translational repression machinery. The first type of granules, pi-bodies, contains the MILI-TDRD1 module of the piRNA pathway and is likely equivalent to the enigmatic “cementing material” first described in electron micrographs of rat gonocytes over 35 years ago. The second type of granules, piP-bodies, harbors the MIWI2-TDRD9-MAEL module of the piRNA pathway and signature components of P-bodies, GW182, DCP1a, DDX6/p54, and XRN1 proteins. piP-bodies are found predominantly in the proximity of pi-bodies and the two frequently share mouse VASA homolog (MVH) protein, an RNA helicase. In Mael-mutant gonocytes, MIWI2, TDRD9, and MVH are lost from piP-bodies, whereas no effects on pi-body composition are observed. Further analysis revealed that MAEL appears to specifically facilitate MIWI2-dependent aspects of the piRNA pathway including biogenesis of secondary piRNAs, de novo DNA methylation, and efficient downregulation of TEs. Cumulatively, our data reveal elaborate cytoplasmic compartmentalization of the fetal piRNA pathway that relies on MAEL function

Гидроакустическое устройство профилирования донного грунта с синтезированной апертурой

Introduction. Acoustic profiling is a conventional method for studying the geological structure of the seabed. To this end, a low-frequency acoustic profiler with an operating frequency range of 1…14 kHz can be used. However, under lower operating frequencies, the difficulty of achieving the required resolution arises. The problem of improving the angular resolution of a hydroacoustic device, particularly in the direction of the carrier movement, remains to be a priority task in the search and detection of objects on the seabed, as well as the study of the bottom soil structure. Angular resolution can be improved through several approaches, including an algorithm for synthesizing the antenna aperture based on the law of the phase change of the reflected signal. This approach is relevant in the design of highresolution hydroacoustic tools.Aim. To demonstrate the possibility of constructing a bottom soil profiling device, as well as the possibility of increasing its angular resolution based on an algorithm for synthesizing the antenna aperture of an acoustic profiler.Materials and methods. The study employed the groundwork data obtained for side-scan sonars with a synthetic aperture in terms of constructing an antenna device and the methods of radio-wave excitation developed for radar systems.Results. The possibility of synthesizing the antenna aperture for an acoustic profiler of the bottom soil was studied. An algorithm for synthesizing the antenna aperture was investigated along with phase distortions of the trajectory signal and their influence on the sonar image. The fundamental principles of processing the trajectory signal were considered.Conclusion. An approach to increasing the resolution of an acoustic profiler when performing search and survey tasks is proposed. The proposed design of the acoustic part of a profiling device can be used in the development of search and survey hydroacoustic devices with a high angular resolution.Введение. Акустическое профилирование является традиционным методом исследования геологического строения морского дна. Для этих целей используется низкочастотный акустический профилограф с рабочим диапазоном частот 1…14 кГц. Однако при понижении рабочих частот возникает проблема с достижением необходимой разрешающей способности.  Проблема повышения углового разрешения гидроакустического устройства, или, иначе говоря, повышение разрешающей способности в направлении движения носителя, является одной из приоритетных задач при поиске и обнаружении объектов на морском дне, исследовании структуры донного грунта. Существует несколько способов повышения углового разрешения, одним из которых является алгоритм синтезирования апертуры антенны, базирующийся на использовании закона изменения фазы отраженного сигнала, что является актуальным при проектировании гидроакустических средств высокого разрешения.Цель работы. Показать возможность построения устройства профилирования донного грунта, а также возможность повышения углового разрешения на основе алгоритма синтезирования апертуры антенны акустического профилографа.Материалы и методы. Исследование возможности построения устройства профилирования донного грунта с использованием алгоритма синтезирования апертуры антенны основано на заделе, полученном для гидролокаторов бокового обзора с синтезированной апертурой в части построения антенного устройства, а также на методах возбуждения радиоволн, разработанных для радиолокационных систем.Результаты. Исследована возможность применения синтезирования апертуры антенны для акустического профилографа донного грунта. Рассмотрен алгоритм синтезирования апертуры антенны, а также фазовые искажения траекторного сигнала и их влияние на гидролокационное изображение, а также основы обработки траекторного сигнала.Заключение. В работе предложен вариант повышения разрешающей способности акустического профилографа при выполнении поисково-обследовательских задач. Предлагаемый вариант построения акустической части устройства профилирования может быть использован при разработке поисково-обследовательских гидроакустических устройств с высоким угловым разрешением