Differential clinical characteristics and prognosis of intraventricular conduction defects in patients with chronic heart failure

Intraventricular conduction defects (IVCDs) can impair prognosis of heart failure (HF), but their specific impact is not well established. This study aimed to analyse the clinical profile and outcomes of HF patients with LBBB, right bundle branch block (RBBB), left anterior fascicular block (LAFB), and no IVCDs. Clinical variables and outcomes after a median follow-up of 21 months were analysed in 1762 patients with chronic HF and LBBB (n = 532), RBBB (n = 134), LAFB (n = 154), and no IVCDs (n = 942). LBBB was associated with more marked LV dilation, depressed LVEF, and mitral valve regurgitation. Patients with RBBB presented overt signs of congestive HF and depressed right ventricular motion. The LAFB group presented intermediate clinical characteristics, and patients with no IVCDs were more often women with less enlarged left ventricles and less depressed LVEF. Death occurred in 332 patients (interannual mortality = 10.8%): cardiovascular in 257, extravascular in 61, and of unknown origin in 14 patients. Cardiac death occurred in 230 (pump failure in 171 and sudden death in 59). An adjusted Cox model showed higher risk of cardiac death and pump failure death in the LBBB and RBBB than in the LAFB and the no IVCD groups. LBBB and RBBB are associated with different clinical profiles and both are independent predictors of increased risk of cardiac death in patients with HF. A more favourable prognosis was observed in patients with LAFB and in those free of IVCDs. Further research in HF patients with RBBB is warranted

CARB-ES-19 Multicenter Study of Carbapenemase-Producing Klebsiella pneumoniae and Escherichia coli From All Spanish Provinces Reveals Interregional Spread of High-Risk Clones Such as ST307/OXA-48 and ST512/KPC-3

ObjectivesCARB-ES-19 is a comprehensive, multicenter, nationwide study integrating whole-genome sequencing (WGS) in the surveillance of carbapenemase-producing K. pneumoniae (CP-Kpn) and E. coli (CP-Eco) to determine their incidence, geographical distribution, phylogeny, and resistance mechanisms in Spain.MethodsIn total, 71 hospitals, representing all 50 Spanish provinces, collected the first 10 isolates per hospital (February to May 2019); CPE isolates were first identified according to EUCAST (meropenem MIC > 0.12 mg/L with immunochromatography, colorimetric tests, carbapenem inactivation, or carbapenem hydrolysis with MALDI-TOF). Prevalence and incidence were calculated according to population denominators. Antibiotic susceptibility testing was performed using the microdilution method (EUCAST). All 403 isolates collected were sequenced for high-resolution single-nucleotide polymorphism (SNP) typing, core genome multilocus sequence typing (cgMLST), and resistome analysis.ResultsIn total, 377 (93.5%) CP-Kpn and 26 (6.5%) CP-Eco isolates were collected from 62 (87.3%) hospitals in 46 (92%) provinces. CP-Kpn was more prevalent in the blood (5.8%, 50/853) than in the urine (1.4%, 201/14,464). The cumulative incidence for both CP-Kpn and CP-Eco was 0.05 per 100 admitted patients. The main carbapenemase genes identified in CP-Kpn were blaOXA–48 (263/377), blaKPC–3 (62/377), blaVIM–1 (28/377), and blaNDM–1 (12/377). All isolates were susceptible to at least two antibiotics. Interregional dissemination of eight high-risk CP-Kpn clones was detected, mainly ST307/OXA-48 (16.4%), ST11/OXA-48 (16.4%), and ST512-ST258/KPC (13.8%). ST512/KPC and ST15/OXA-48 were the most frequent bacteremia-causative clones. The average number of acquired resistance genes was higher in CP-Kpn (7.9) than in CP-Eco (5.5).ConclusionThis study serves as a first step toward WGS integration in the surveillance of carbapenemase-producing Enterobacterales in Spain. We detected important epidemiological changes, including increased CP-Kpn and CP-Eco prevalence and incidence compared to previous studies, wide interregional dissemination, and increased dissemination of high-risk clones, such as ST307/OXA-48 and ST512/KPC-3

The IULA Treebank

Comunicació presentada al 8th International Conference on Language Resources and Evaluation (LREC'12), celebrat del 21 al 27 de maig de 2012 a Istanbul, Turquia.This paper describes on-going work for the construction of a new treebank for Spanish, The IULA Treebank. This new resource will contain about 60,000 richly annotated sentences as an extension of the already existing IULA Technical Corpus which is only PoS tagged. In this paper we have focused on describing the work done for defining the annotation process and the treebank design principles. We report on how the used framework, the DELPH-IN processing framework, has been crucial in the design principles and in the bootstrapping strategy followed, especially in what refers to the use of stochastic modules for reducing parsing overgeneration. We also report on the different evaluation experiments carried out to guarantee the quality of the already available results.This work was co-funded by the Ramón y Cajal program of the Spanish Ministerio de Ciencia e Innovación, the EU UNER - Competitiveness and Innovation Framework Program, METANET (CIP-PSP-270893), and the UPFIULA PhD grant program. We wish to thank also to Stephan Oepen for his assistance in using the DELPH-IN environment and Lluís Padró for his assistance in the significance calculation

The IULA Spanish LSP treebank: building and browsing

Comunicació presentada al 9th International Conference on Language Resources and Evaluation (LREC'14), celebrat del 26 al 31 de maig de 2014 a Reykjavík, Islàndia.This paper presents the IULA Spanish LSP Treebank, a dependency treebank of over 41,000 sentences of different domains (Law, Economy, Computing Science, Environment, and Medicine), developed in the framework of the European project METANET4U. Dependency annotations in the treebank were automatically derived from manually selected parses produced by an HPSG-grammar by a deterministic conversion algorithm that used the identifiers of grammar rules to identify the heads, the dependents, and some dependency types that were directly transferred onto the dependency structure (e.g., subject, specifier, and modifier), and the identifiers of the lexical entries to identify the argument-related dependency functions (e.g. direct object, indirect object, and oblique complement). The treebank is accessible with a browser that provides concordance-based search functions and delivers the results in two formats: (i) a column-based format, in the style of CoNLL-2006 shared task, and (ii) a dependency graph, where dependency relations are noted by an oriented arrow which goes from the dependent node to the head node. The IULA Spanish LSP Treebank is the first technical corpus of Spanish annotated at surface syntactic level following the dependency grammar theory. The treebank has been made publicly and freely available from the META-SHARE platform with a Creative Commons CC-by licence.This work was co-funded by the Ramon y Cajal program of the Spanish Ministerio de Ciencia e Innovacion, the EU UNER - Competitiveness and Innovation Framework Program, METANET (CIP-PSP-270893), and the UPF-IULA PhD grant program