16 research outputs found
Assisting PNA transport through cystic fibrosis human airway epithelia with biodegradable hybrid lipid-polymer nanoparticles
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Cystic fibrosis (CF) is characterized by an airway obstruction caused by a thick mucus due to a malfunctioning Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein. The sticky mucus restricts drugs in reaching target cells limiting the efficiency of treatments. The development of new approaches to enhance drug delivery to the lungs represents CF treatment's main challenge. In this work, we report the production and characterization of hybrid core-shell nanoparticles (hNPs) comprising a PLGA core and a dipalmitoylphosphatidylcholine (DPPC) shell engineered for inhalation. We loaded hNPs with a 7-mer peptide nucleic acid (PNA) previously considered for its ability to modulate the post-transcriptional regulation of the CFTR gene. We also investigated the in vitro release kinetics of hNPs and their efficacy in PNA delivery across the human epithelial airway barrier using an ex vivo model based on human primary nasal epithelial cells (HNEC) from CF patients. Confocal analyses and hNPs transport assay demonstrated the ability of hNPs to overcome the mucus barrier and release their PNA cargo within the cytoplasm, where it can exert its biological function
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- Author
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- Abbott B
- Abbott DC
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- Publication venue
- EUROPEAN PHYSICAL JOURNAL C
- Publication date
- 03/02/2022
- Field of study
This paper presents the measurement of the electroweak production of two jets
in association with a ZÎł pair with the Z boson decaying into two
neutrinos. It also presents the search for invisible or partially invisible
decays of a Higgs boson with a mass of 125 GeV produced through vector-boson
fusion with a photon in the final state. These results use data from LHC
proton-proton collisions at sâ = 13 TeV collected with the ATLAS
detector corresponding to an integrated luminosity of 139 fbâ1. The event
signature, shared by all benchmark processes considered for measurements and
searches, is characterized by a significant amount of unbalanced transverse
momentum and a photon in the final state, in addition to a pair of forward
jets. For electroweak production of ZÎł in association with two jets, the
background-only hypothesis is rejected with an observed (expected) significance
of 5.2 (5.1) standard deviations. The measured fiducial cross-section for this
process is 1.31±0.29 fb. Observed (expected) upper limit of 0.37 (0.34) at
95% confidence level is set on the branching ratio of a 125 GeV Higgs boson to
invisible particles, assuming the Standard Model production cross-section. The
signature is also interpreted in the context of decays of a Higgs boson to a
photon and a dark photon. An observed (expected) 95% CL upper limit on the
branching ratio for this decay is set at 0.018 (0.017), assuming the 125 GeV
Standard Model Higgs boson production cross-section
Observation of electroweak production of two jets in association with an isolated photon and missing transverse momentum, and search for a Higgs boson decaying into invisible particles at 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abbott DC
- Abeling K
- Abhayasinghe DK
- Abidi SH
- Aboulhorma A
- Abramowicz H
- Abreu H
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- Acharya BS
- Achkar B
- Adam L
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- Addepalli SV
- Adelman J
- Adiguzel A
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- Adye T
- Affolder AA
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- Agaras MN
- Agarwala J
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- Alberghi GL
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- Zhemchugov A
- Zheng Z
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- Zhulanov V
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- Zimine NI
- Zimmermann S
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- Zoccoli A
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- Zorbas TG
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- Ă kesson TPA
- Ăncel ĂO
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- EUROPEAN PHYSICAL JOURNAL C
- Publication date
- 01/01/2022
- Field of study
This paper presents the measurement of the electroweak production of two jets
in association with a ZÎł pair with the Z boson decaying into two
neutrinos. It also presents the search for invisible or partially invisible
decays of a Higgs boson with a mass of 125 GeV produced through vector-boson
fusion with a photon in the final state. These results use data from LHC
proton-proton collisions at sâ = 13 TeV collected with the ATLAS
detector corresponding to an integrated luminosity of 139 fbâ1. The event
signature, shared by all benchmark processes considered for measurements and
searches, is characterized by a significant amount of unbalanced transverse
momentum and a photon in the final state, in addition to a pair of forward
jets. For electroweak production of ZÎł in association with two jets, the
background-only hypothesis is rejected with an observed (expected) significance
of 5.2 (5.1) standard deviations. The measured fiducial cross-section for this
process is 1.31±0.29 fb. Observed (expected) upper limit of 0.37 (0.34) at
95% confidence level is set on the branching ratio of a 125 GeV Higgs boson to
invisible particles, assuming the Standard Model production cross-section. The
signature is also interpreted in the context of decays of a Higgs boson to a
photon and a dark photon. An observed (expected) 95% CL upper limit on the
branching ratio for this decay is set at 0.018 (0.017), assuming the 125 GeV
Standard Model Higgs boson production cross-section
Observation of electroweak production of two jets in association with an isolated photon and missing transverse momentum, and search for a Higgs boson decaying into invisible particles at 13 TeV with the ATLAS detector
- Author
- Aad G.
- Abbott B.
- Abbott D. C.
- Abed Abud A.
- Abeling K.
- Abhayasinghe D. K.
- Abidi S. H.
- Aboulhorma A.
- Abramowicz H.
- Abreu H.
- Abulaiti Y.
- Abusleme Hoffman A. C.
- Acharya B. S.
- Achkar B.
- Adam Bourdarios C.
- Adam L.
- Adamczyk L.
- Adamek L.
- Addepalli S. V.
- Adelman J.
- Adiguzel A.
- Adorni S.
- Adye T.
- Affolder A. A.
- Afik Y.
- Agapopoulou C.
- Agaras M. N.
- Agarwala J.
- Aggarwal A.
- Agheorghiesei C.
- Aguilar-Saavedra J. A.
- Ahmad A.
- Ahmadov F.
- Ahmed W. S.
- Ai X.
- Aielli G.
- Aizenberg I.
- Akatsuka S.
- Akbiyik M.
- Akimov A. V.
- Al Khoury K.
- Alberghi G. L.
- Albert J.
- Albicocco P.
- Alconada Verzini M. J.
- Alderweireldt S.
- Aleksa M.
- Aleksandrov I. N.
- Alexa C.
- Alexopoulos T.
- Alfonsi A.
- Alfonsi F.
- Alhroob M.
- Ali B.
- Ali S.
- Aliev M.
- Alimonti G.
- Allaire C.
- Allbrooke B. M. M.
- Allport P. P.
- Aloisio A.
- Alonso F.
- Alpigiani C.
- Alunno Camelia E.
- Alvarez Estevez M.
- Alviggi M. G.
- Amaral Coutinho Y.
- Ambler A.
- Ambroz L.
- Amelung C.
- Amidei D.
- Amor Dos Santos S. P.
- Amoroso S.
- Amrouche C. S.
- Anastopoulos C.
- Andari N.
- Andeen T.
- Anders J. K.
- Andrean S. Y.
- Andreazza A.
- Angelidakis S.
- Angerami A.
- Anisenkov A. V.
- Annovi A.
- Antel C.
- Anthony M. T.
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- ĆœeniĆĄ T.
- ĆœivkoviÄ L.
- Publication venue
- Springer
- Publication date
- 01/01/2022
- Field of study
This paper presents a measurement of the electroweak production of two jets in association with a ZÎł pair, with the Z boson decaying into two neutrinos. It also presents a search for invisible or partially invisible decays of a Higgs boson with a mass of 125 GeV produced through vector-boson fusion with a photon in the final state. These results use data from LHC protonâproton collisions at s = 13 TeV collected with the ATLAS detector and corresponding to an integrated luminosity of 139 fb-1. The event signature, shared by all benchmark processes considered for the measurements and searches, is characterized by a significant amount of unbalanced transverse momentum and a photon in the final state, in addition to a pair of forward jets. Electroweak ZÎł production in association with two jets is observed in this final state with a significance of 5.2 (5.1 expected) standard deviations. The measured fiducial cross-section for this process is 1.31±0.29 fb. An observed (expected) upper limit of 0.37 (0.34-0.10+0.15) at 95% confidence level is set on the branching ratio of a 125 GeV Higgs boson to invisible particles, assuming the Standard Model production cross-section. The signature is also interpreted in the context of decays of a Higgs boson into a photon and a dark photon. An observed (expected) 95% CL upper limit on the branching ratio for this decay is set at 0.018 (0.017-0.005+0.007), assuming the Standard Model production cross-section for a 125 GeV Higgs boson
La formazione per direttori generali
- Publication venue
- Aracne editrice
- Publication date
- 01/01/2015
- Field of study
La Formazione per i Dirigenti Generali: Riflessioni a Margine dell'Esperienza Pugliese
- Publication venue
- place:Roma
- Publication date
- 01/01/2012
- Field of study
HLA and prognostic factors in primary breast cancer
- Publication venue
- 'Wiley'
- Publication date
- 01/01/1985
- Field of study
HLA and prognostic factors in primary breast cancer
- Author
- Publication venue
- John Wiley & Sons Incorporated:Customer Service, 111 River Street:Hoboken, NJ 07030:(800)225-5945, (201)748-6000, EMAIL: [email protected], INTERNET: http://www.wiley.com, Fax: (212)748-6551
- Publication date
- 01/01/1985
- Field of study
Hla and Prognostic Factors In Primary Breast-cancer
- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/01/1985
- Field of study
A multicomponent food supplement with bromelain, escin, and selenium in patients with urological medical disorders
- Author
- Damiano Bracchitta
- Domenico Pezzotti
- Enrico Conti
- Fabrizio Fioretti
- Felice Crocetto
- Francesco Abate
- Francesco Boezio
- Francesco Valentino
- G. Ciprandi
- G. Savoca
- Gennaro Annunziata
- Gennaro Marcello
- Giancarlo Salemi
- Giancarlo Ungaro
- Giovanni Bologna
- Giuseppe Alberto Ventrice
- Giuseppina Azzarito
- Lorenzo Falcone
- M. Zanoni
- Marco Alessandrini
- Mario Di Martino
- Massimo Madonia
- Maurizio Motta
- Mauro Seveso
- Michele De Martin
- Nicola Macchione
- Nino Dispensa
- O. Sedigh
- Patrizia Morello
- Pietro De Antoni
- Raffaele Galasso
- Renzo Verani
- S. E. Aragona
- Sandro Guglielmetti
- Silvio Giacomo Festa
- Vincenzo Viscusi
- Willy Giannubilo
- Zuhair Rimawi
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Urological disorders are very common and affect any age. The most common medical conditions include cystitis, urolithiasis, renal colic, and prostatitis. BroserÂź is a food supplement containing bromelain, escin,and selenium. Its efficacy has been positively tested in patients with otorhinolaryngological disorders.Therefore, the present clinical experience investigated the efficacy and safety of this product in patients with medical urological disorders and treated with standard therapy. The add-on BroserÂź course lasted 2 weeks. The oral nutraceutical was taken following the specific indications, such as two tablets/daily. Patients were visited at baseline (T0) and after the treatment (T1). Patients in Group A had to take BroserÂź one tablet b.i.d. per 20 days. Evaluation parameters were the following signs and symptoms: pain, functional powerlessness, fever, oedema, malaise, dysuria, and infection severity. Globally, 1,204 patients participated in this clinical experience. The median age was 52 years. The food supplement significantly reduced the symptom severity and the incidence of symptoms. In conclusion, the present clinical experience demonstrated that the add-on therapy with BroserÂź significantly reduced the severity and incidence of urological complaints. Therefore, this food supplement could be fruitfully used in clinical practice