Audiometric Evaluation of the Relationship between Sensorineural Hearing Loss and Chronic Glaucoma

Objectives:To assess hearing function in chronic glaucoma patients in comparison to healthy individuals.Materials and Methods:This cross-sectional study included 24 primary open-angle glaucoma (POAG) patients (24 ears) and 22 pseudoexfoliative glaucoma (PEG) patients (22 ears) who were followed for at least 5 years in the Afyonkarahisar Health Sciences University Ophthalmology Department, as well as 21 age- and gender-matched healthy individuals (21 ears, control group). Following a thorough ophthalmological examination that included visual acuity and intraocular pressure measurements, as well as anterior and posterior slit-lamp biomicroscopy, audiometry was performed in all participants to determine hearing function.Results:Mean ages in the POAG, PEG, and control groups were 64.50±7, 66.90±4.51, and 64.38±4.36 years, respectively. The mean deviation in standard automated perimetry was -14.47±2.89 in the POAG group and -15.02±2.87 in the PEG group (p=0.306). When compared with the control group, the POAG group had significantly higher hearing thresholds at 500 (p=0.011) and 1,000 Hz (p=0.003), while the PEG group had significantly higher hearing thresholds at 250 (p=0.009), 500 (p=0.009), 1,000 (p=0.001), 2,000 (p=0.005), 4,000 (p=0.001), 8000 (p=0.010), and 10,000 Hz (p=0.009).Conclusion:Both glaucoma and hearing loss are common chronic diseases that have an impact on the well-being of older people. Potential hearing problems in chronic glaucoma patients make routine ocular and otolaryngology examinations in older patients critical for prompt diagnosis and treatment

Autologous Stem Cell Transplantation in Multiple Myeloma Patients Over 60 Years Old

The incidence of Multiple myeloma (MM) increases with age; two-thirds of the patients are older than 65 years. Induction treatment, including new agents such as thalidomide, bortezomib, and lenalidomide followed by a conditioning regimen and upfront autologous stem cell transplantation (ASCT), has been accepted the standard treatment approach for newly diagnosed fit MM patients. We aimed to search the real-life data, the efficacy and safety of upfront ASCT following induction in patients with MM over 60 years old retrospectively. The data of MM patients who were ≥60 years old during autologous stem cell transplantation and treated at our center between 2010 and 2018 retrospectively analyzed. The study results were 63 patients included at the age of ≥ 60 years who underwent upfront ASCT. Median PFS was 15.5±2.6 months, and the median overall survival (OS) was 28.15±5 months. According to age groups, median PFS was 12±2.3 months in the 60-64 age group, 18.4±6 months in the 65-69 age group, and 26±15 months in the ≥70 age group. Median OS was 26.5±6.1 months in the 60-64 age group, 39.66±8.9 months in the 65-69 age group, and 18 months in the ≥70 age group. A significant relationship between the quantity of infused CD34+ stem cells and PFS and OS (p:0.05 and

Early Relapse After Autologous Stem Cell Transplantation in Multiple Myeloma is Still Prognostic in The Era of Novel Agents

Significant improvements in the prognosis of Multiple Myeloma(MM) have recently observed in the era of novel agents. Induction treatment, including new agents followed by conditioning regimen and upfront autologous stem cell transplantation(ASCT), has been accepted as the standard treatment approach for newly diagnosed eligible MM patients. Despite novel agents, upfront ASCT is still superior to conventional chemotherapy alone. Previous studies revealed that the duration between ASCT and relapse had predicted overall survival(OS), and meantime, it was widely used to determine the potential benefit from a second ASCT. However, the majority of the data collected reflects the treatment modalities before novel agents. In this study, we aimed to investigate the impact of post-transplantation early relapse(ER) on survival in the era of novel agents. The results of 155 MM patients that underwent ASCT at our center between January 2010 and May 2018 were analyzed retrospectively. The median follow-up duration was 20 months in the ER group, 27 months in the non-ER group, and 24 months in all patients. 33.3% of patients in the ER group and 71.4% of patients in the non-ER group were alive at the time of analysis. Median OS was 20.77±3.66 months in the ER group and 40.89±4.21 months in the non-ER group. We found a statistically significant relationship between the ER and the poor OS (p

Cambrian-Eocene pre-rift, pulsed rift, passive margin and emplacement processes along the northern margin of the Southern Neotethys: evidence from the Antalya Complex in the Alanya Window (S Turkey)

Sedimentary rocks in the Alanya Window document pulsed Permian-Triassic rifting in a proximal basin setting, adjacent to the Tauride continental unit (Geyik Dağ). Late Cambrian-Early Ordovician clastic sediments accumulated along the north margin of Gondwana on a variable shallow-marine shelf. Above an unconformity related to rift-shoulder uplift, Late Permian facies document shallow-marine to evaporitic environments during regional tectonic subsidence (first main rift pulse). Above a second unconformity (both extension and sea-level controlled), Early Triassic carbonates and mudrocks accumulated on an unstable, gently subsiding shelf. Mudrocks, sandstones and lithoclastic debris-flows, derived from the underlying succession, accumulated during the Middle Triassic (Anisian-early Ladinian), implying strong tectonic subsidence and flank uplift (second main rift pulse). Radiolarian mudstones accumulated during late Middle Triassic-early Late Triassic in a well-oxidised, organically productive, but relatively quiescent, deep-water basin above the carbonate compensation depth (CCD). Thick (100s m) lithoclastic sandstone turbidites (commonly plant-rich) and localised debris-flows accumulated during the Late Triassic (Carnian), together with detached blocks of underlying lithologies (third main rift pulse, with regional uplift). Alkaline basaltic sills were intruded locally. Final continental break-up to create the Southern Neotethys took place regionally during the Late Triassic (Carnian). Latest Triassic-Late Cretaceous deposition records passive margin subsidence. Variable low-grade metamorphism and two-stage tectonic emplacement (southwards(?) then northwards) took place during latest Cretaceous and Eocene, respectively. The tectonic-sedimentary development of the Antalya Complex provides insights into rift/continental break-up processes that differ from the recently well-documented Alpine-North Atlantic region.Publisher PDFPeer reviewe

Larenks cerrahisi sırasında insidental olarak saptanan tiroid karsinomlarının değerlendirilmesi

Aim: The purpose of this study is to evaluate the possibility of incidental thyroid carcinomas during laryngeal surgery. Materials and Methods: Seventy three patients who were treated surgically for squamous cell carcinoma of larynx at the Otolaryngology Department of Ankara Oncology Education and Research Hospital, over 18 months period between 2003-2004 were included, out of which 4 thyroid carcinomas detected. Results: Among these patients with larynx tumor, one of them had follicular variant of thyroid papillary carcinoma, the other had thyroid papillary carcinoma metastases of cervical lymph node and the third one had thyroid papillary microcarcinoma and the last one had follicular thyroid carcinoma. Total thyroidectomy and contralateral neck dissection was performed to one of them and the other three patients had complementary thyroidectomy and contralateral neck dissection. All patients were free of disease after 11-9-17-11 months of follow-up respectively. Conclusion: Thyroid tissue must be evaluated carefully for thyroid carcinoma during laryngectomy. In our opinion, intraoperative evaluation of the thyroid gland is very important because coexistent of thyroid malignancy with laryngeal carcinoma can be more than it’s expected.Amaç: Bu çalışmanın amacı, laryngeal cerrahi sırasında insidental olarak bulunan tiroid karsinomu olasılığını değerlendirmektir. Gereç ve Yöntem: Çalışmaya larenks skuamöz hücreli karsinomu nedeniyle Ankara Onkoloji Eğtitim Araştırma Hastanesinde 2003-2004 yılları arasında 18 ay boyunca larenks cerrahisi uygulanan toplam 73 hasta değerlendirilerek bulunan 4 adet tiroid karsinomlu hasta dahil edilmiştir. Bulgular: Larenks skuamöz hücreli karsinom tanılı hastalar arasından birinci hastanın tiroid papiller karsinomun foliküler varyantı, ikinci hastanın lenf nodu metastazlı tiroid papiller karsinomu, üçüncü hastanın tiroid papiller mikrokarsinomu ve dördüncü hastanın foliküler tiroid karsinomu mevcuttu. 1 hastaya total tiroidektomi ve kontralateral boyun diseksiyonu, diğer hastalara da komplementer tiroidektomi ve kontralateral boyun diseksiyonu uygulandı. Tüm hastalar sırasıyla 11-9-17-11 ay boyunca hastalıksız olarak takip edildi. Sonuç: Larenjektomi sırasında tiroid karsinomu açısından tiroid dokusu dikkatli bir biçimde değerlendirilmelidirTiroid bezinin intraoperatif olarak değerlendirilmesi çok önemlidir. Çünkü larengeal karsinomla birlikte bulunan bir tiroid malignitesi ile beklenildiğinden çok daha sık karşılaşılabilmektedi

Selective neck dissection and efficiency

Baş boyun epidermoid karsinomlarında, servikal lenf nodları metastazının varlığı prognozda büyük önem taşımaktadır. Metastatik lenf nodları varlığının tespiti ve diseksiyonu en az primer tümör bölgesine müdahale etmek kadar önemlidir.Cervical lymph node metastasis have great importance role in prognosis of head and neck epidermoid carsinomas. To determine and dissect the metastatic lymph nodes is as important as interventing to the region of primary of the tumor

Larenks cerrahisi sırasında insidental olarak saptanan tiroid karsinomlarının değerlendirilmesi

Aim: The purpose of this study is to evaluate the possibility of incidental thyroid carcinomas during laryngeal surgery. Materials and Methods: Seventy three patients who were treated surgically for squamous cell carcinoma of larynx at the Otolaryngology Department of Ankara Oncology Education and Research Hospital, over 18 months period between 2003-2004 were included, out of which 4 thyroid carcinomas detected. Results: Among these patients with larynx tumor, one of them had follicular variant of thyroid papillary carcinoma, the other had thyroid papillary carcinoma metastases of cervical lymph node and the third one had thyroid papillary microcarcinoma and the last one had follicular thyroid carcinoma. Total thyroidectomy and contralateral neck dissection was performed to one of them and the other three patients had complementary thyroidectomy and contralateral neck dissection. All patients were free of disease after 11-9-17-11 months of follow-up respectively. Conclusion: Thyroid tissue must be evaluated carefully for thyroid carcinoma during laryngectomy. In our opinion, intraoperative evaluation of the thyroid gland is very important because coexistent of thyroid malignancy with laryngeal carcinoma can be more than it’s expected.Amaç: Bu çalışmanın amacı, laryngeal cerrahi sırasında insidental olarak bulunan tiroid karsinomu olasılığını değerlendirmektir. Gereç ve Yöntem: Çalışmaya larenks skuamöz hücreli karsinomu nedeniyle Ankara Onkoloji Eğtitim Araştırma Hastanesinde 2003-2004 yılları arasında 18 ay boyunca larenks cerrahisi uygulanan toplam 73 hasta değerlendirilerek bulunan 4 adet tiroid karsinomlu hasta dahil edilmiştir. Bulgular: Larenks skuamöz hücreli karsinom tanılı hastalar arasından birinci hastanın tiroid papiller karsinomun foliküler varyantı, ikinci hastanın lenf nodu metastazlı tiroid papiller karsinomu, üçüncü hastanın tiroid papiller mikrokarsinomu ve dördüncü hastanın foliküler tiroid karsinomu mevcuttu. 1 hastaya total tiroidektomi ve kontralateral boyun diseksiyonu, diğer hastalara da komplementer tiroidektomi ve kontralateral boyun diseksiyonu uygulandı. Tüm hastalar sırasıyla 11-9-17-11 ay boyunca hastalıksız olarak takip edildi. Sonuç: Larenjektomi sırasında tiroid karsinomu açısından tiroid dokusu dikkatli bir biçimde değerlendirilmelidirTiroid bezinin intraoperatif olarak değerlendirilmesi çok önemlidir. Çünkü larengeal karsinomla birlikte bulunan bir tiroid malignitesi ile beklenildiğinden çok daha sık karşılaşılabilmektedi

Selective neck dissection and efficiency

Baş boyun epidermoid karsinomlarında, servikal lenf nodları metastazının varlığı prognozda büyük önem taşımaktadır. Metastatik lenf nodları varlığının tespiti ve diseksiyonu en az primer tümör bölgesine müdahale etmek kadar önemlidir.Cervical lymph node metastasis have great importance role in prognosis of head and neck epidermoid carsinomas. To determine and dissect the metastatic lymph nodes is as important as interventing to the region of primary of the tumor