Chemical structure matching using correlation matrix memories

This paper describes the application of the Relaxation By Elimination (RBE) method to matching the 3D structure of molecules in chemical databases within the frame work of binary correlation matrix memories. The paper illustrates that, when combined with distributed representations, the method maps well onto these networks, allowing high performance implementation in parallel systems. It outlines the motivation, the neural architecture, the RBE method and presents some results of matching small molecules against a database of 100,000 models

Abelian homotopy Dijkgraaf-Witten theory

We construct a version of Dijkgraaf-Witten theory based on a compact abelian Lie group within the formalism of Turaev's homotopy quantum field theory. As an application we show that the 2+1-dimensional theory based on U(1) classifies lens spaces up to homotopy type.Comment: 23 pages, 1 figur

The XMM-Newton Iron Line Profile of NGC 3783

We report on observations of the iron K line in the nearby Seyfert 1 galaxy, NGC 3783, obtained in a long, 2 orbit (240 ks) XMM-Newton observation. The line profile obtained exhibits two strong narrow peaks at 6.4 keV and at 7.0 keV, with measured line equivalent widths of 120 and 35 eV respectively. The 6.4 keV emission is the K-alpha line from near neutral Fe, whilst the 7.0 keV feature probably originates from a blend of the neutral Fe K-beta line and the H-like line of Fe at 6.97 keV. The relatively narrow velocity width of the K-alpha line (<5000 km/s), its lack of response to the continuum emission on short timescales and the detection of a neutral Compton reflection component are all consistent with a distant origin in Compton-thick matter such as the putative molecular torus. A strong absorption line from highly ionized iron (at 6.67 keV) is detected in the time-averaged iron line profile, whilst the depth of the feature appears to vary with time, being strongest when the continuum flux is higher. The iron absorption line probably arises from the highest ionization component of the known warm absorber in NGC 3783, with an ionization of logxi=3 and column density of 5x10^{22}cm{-2} and may originate from within 0.1pc of the nucleus. A weak red-wing to the iron K line profile is also detected below 6.4 keV. However when the effect of the highly ionized warm absorber on the underlying continuum is taken into account, the requirement for a relativistic iron line component from the inner disk is reduced.Comment: 34 pages, including 11 figures. Accepted for publication in Ap

Introducing creativity techniques and software apps to the care of people with dementia

This poster reports research to introduce creative problem solving techniques and software to the care for people with dementia in residential homes

What is the impact of psychiatric decision units on mental health crisis care pathways? Protocol for an interrupted time series analysis with a synthetic control study

Background The UK mental health system is stretched to breaking point. Individuals presenting with mental health problems wait longer at the ED than those presenting with physical concerns and finding a bed when needed is difficult – 91% of psychiatric wards are operating at above the recommended occupancy rate. To address the pressure, a new type of facility – psychiatric decision units (also known as mental health decision units) – have been introduced in some areas. These are short-stay facilities, available upon referral, targeted to help individuals who may be able to avoid an inpatient admission or lengthy ED visit. To advance knowledge about the effectiveness of this service for this purpose, we will examine the effect of the service on the mental health crisis care pathway over a 4-year time period; the 2 years proceeding and following the introduction of the service. We use aggregate service level data of key indicators of the performance of this pathway. Methods Data from four mental health Trusts in England will be analysed using an interrupted time series (ITS) design with the primary outcomes of the rate of (i) ED psychiatric presentations and (ii) voluntary admissions to mental health wards. This will be supplemented with a synthetic control study with the same primary outcomes, in which a comparable control group is generated for each outcome using a donor pool of suitable National Health Service Trusts in England. The methods are well suited to an evaluation of an intervention at a service delivery level targeting population-level health outcome and the randomisation or ‘trialability’ of the intervention is limited. The synthetic control study controls for national trends over time, increasing our confidence in the results. The study has been designed and will be carried out with the involvement of service users and carers. Discussion This will be the first formal evaluation of psychiatric decision units in England. The analysis will provide estimates of the effect of the decision units on a number of important service use indicators, providing much-needed information for those designing service pathways

ASCA observations of type-2 Seyfert galaxies: II. The Importance of X-ray Scattering and Reflection

We discuss the importance of X-ray scattering and Compton reflection in type-2 Seyfert galaxies, based upon the analysis of ASCA observations of 25 such sources. Consideration of the iron Kalpha, [O III] line and X-ray variability suggest that NGC 1068, NGC 4945, NGC 2992, Mrk 3, Mrk 463E and Mrk 273 are dominated by reprocessed X-rays. We examine the properties of these sources in more detail. We find that the iron Kalpha complex contains significant contributions from neutral and high-ionization species of iron. Compton reflection, hot gas and starburst emission all appear to make significant contributions to the observed X-ray spectra. Mrk 3 is the only source in this subsample which does not have a significant starburst contamination. The ASCA spectrum below 3 keV is dominated by hot scattering gas with U_X ~ 5, N_H ~ 4 x 10^23 cm^-2. This material is more highly ionized than the zone of material comprising the warm absorber seen in Seyfert~1 galaxies, but may contain a contribution from shock-heated gas associated with the jet. Estimates of the X-ray scattering fraction cover 0.25 - 5%. The spectrum above 3 keV appears to be dominated by a Compton reflection component although there is evidence that the primary continuum component becomes visible close to 10 keV.Comment: 27 pages, 6 figures. LaTeX with encapsulated postscript. To appear in the Astrophysical Journal. Also available via http://lheawww.gsfc.nasa.gov/~george/papers/gnt_s2p2/abstract.htm

SHEEP: The Search for the High Energy Extragalactic Population

We present the SHEEP survey for serendipitously-detected hard X-ray sources in ASCA GIS images. In a survey area of $\sim 40$ deg$^{2}$, 69 sources were detected in the 5-10 keV band to a limiting flux of $\sim 10^{-13}$ erg cm$^{-2}$ s$^{-1}$. The number counts agree with those obtained by the similar BeppoSAX HELLAS survey, and both are in close agreement with ASCA and BeppoSAX 2-10 keV surveys. Spectral analysis of the SHEEP sample reveals that the 2-10 and 5-10 keV surveys do not sample the same populations, however, as we find considerably harder spectra, with an average $\Gamma\sim1.0$ assuming no absorption. The implication is that the agreement in the number counts is coincidental, with the 5-10 keV surveys gaining approximately as many hard sources as they lose soft ones, when compared to the 2-10 keV surveys. This is hard to reconcile with standard AGN ``population synthesis'' models for the X-ray background, which posit the existence of a large population of absorbed sources. We find no evidence of the population hardening at faint fluxes, with the exception that the few very brightest objects are anomalously soft. 53 of the SHEEP sources have been covered by ROSAT in the pointed phase. Of these 32 were detected. An additional 3 were detected in the RASS. As expected the sources detected with ROSAT are systematically softer than those detected with ASCA alone, and of the sample as a whole (truncated).Comment: 36 pages, 7 figs, to appear in Ap