Strong Performance Guarantees for Asynchronous Buffered Crossbar Schedulers

Crossbar-based switches are commonly used to implement routers with throughputs up to about 1 Tb/s. The advent of crossbar scheduling algorithms that provide strong performance guarantees now makes it possible to engineer systems that perform well, even under extreme traffic conditions. Until recently, such performance guarantees have only been developed for crossbars that switch cells rather than variable length packets. Cell-based crossbars incur a worst-case bandwidth penalty of up to a factor of two, since they must fragment variable length packets into fixed length cells. In addition, schedulers for cell-based crossbars may fail to deliver the expected performance guarantees when used in routers that forward packets. We show how to obtain performance guarantees for asynchronous crossbars that are directly comparable to those previously developed for synchronous, cell-based crossbars. In particular we define derivatives of the Group by Virtual Output Queue (GVOQ) scheduler of Chuang et al. and the Least Occupied Output First Scheduler of Krishna et al. and show that both can provide strong performance guarantees in systems with speedup 2. Specifically, we show that these schedulers are work-conserving and that they can emulate an output-queued switch using any queueing discipline in the class of restricted Push-In, First-Out queueing disciplines. We also show that there are schedulers for segment-based crossbars, (introduced recently by Katevenis and Passas) that can deliver strong performance guarantees with small buffer requirements and no bandwidth fragmentation

Awareness of the 20-20-20 Rule Amongst Students, Faculty, and Staff

In the past several years, medical schools have increased utilization of recorded lectures and electronic devices: computers, smartphones, and tablets. Increased screen exposure hours where students, faculty, and staff may acquire eye strain. Many are not aware of the 20-20-20 rule: for every 20 minutes of screen time, it is recommended to look at something 20 feet away for 20 seconds; a reminder to take frequent breaks to help prevent eye strain. We want to share reports from our institution regarding student, faculty and staff digital device usage and awareness of the 20-20-20 rule

Assessing the Prevalence of Computer Vision Syndrome at an Osteopathic Medical School with an Electronic Content Delivery Model

To determine the overall prevalence of computer vision syndrome (CVS) among students, faculty, and staff while promoting awareness. CVS is caused by extended screen exposure that can lead to eye discomfort and vision changes which can affect quality of life and educational performance. Our institution is a new Osteopathic medical school that aims to create an innovative approach to medical education delivery via employment of modern technology that is already prevalent. Implementation of pre-recorded lecture materials in the curriculum requires 4-6 additional electronic screen exposure hours. Members of our institution are potentially at increased risk for CVS stemming from the curriculum delivery style and the accelerated use of technology

Delivery of sry1, but not sry2, to the kidney increases blood pressure and sns indices in normotensive wky rats

<p>Abstract</p> <p>Background</p> <p>Our laboratory has shown that a locus on the SHR Y chromosome increases blood pressure (BP) in the SHR rat and in WKY rats with the SHR Y chromosome (SHR/y rat). A candidate for this Y chromosome hypertension locus is Sry, a gene that encodes a transcription factor responsible for testes determination. The SHR Y chromosome has six divergent Sry loci. The following study examined if exogenous <it>Sry1 </it>or Sry2 delivered to the kidney would elevate renal tyrosine hydroxylase, renal catecholamines, plasma catecholamines and telemetered BP over a 28 day period. We delivered 50 μg of either the expression construct Sry1/pcDNA 3.1, Sry2/pcDNA 3.1, or control vector into the medulla of the left kidney of normotensive WKY rats by electroporation. Weekly air stress was performed to determine BP responsiveness. Separate groups of animals were tested for renal function and plasma hormone patterns and pharmacological intervention using alpha adrenergic receptor blockade. Pre-surgery baseline and weekly blood samples were taken from <it>Sry1 </it>electroporated and control vector males for plasma renin, aldosterone, and corticosterone. BP was measured by telemetry and tyrosine hydroxylase and catecholamines by HPLC with electrochemical detection.</p> <p>Results</p> <p>In the animals receiving the <it>Sry1 </it>plasmid there were significant increases after 21 days in resting plasma norepinephrine (NE, 27%) and renal tyrosine hydroxylase content (41%, p < .05) compared to controls. BP was higher in animals electroporated with <it>Sry1 </it>(143 mmHg, p < .05) compared to controls (125 mmHg) between 2–4 weeks. Also the pressor response to air stress was significantly elevated in males electroporated with <it>Sry1 </it>(41 mmHg) compared to controls (28 mmHg, p < .001). <it>Sry2 </it>did not elevate BP or SNS indices and further tests were not done. The hormone profiles for plasma renin, aldosterone, and corticosterone between electroporated <it>Sry1 </it>and control vector males showed no significant differences over the 28 day period. Alpha adrenergic receptor blockade prevented the air stress pressor response in both strains. Urinary dopamine significantly increased after 7 days post Sry electroporation.</p> <p>Conclusion</p> <p>These results are consistent with a role for <it>Sry1 </it>in increasing BP by directly or indirectly activating renal sympathetic nervous system activity.</p

Wet Paint: Visual Culture in a Changing Britain – A Round Table Debate

Political decisions and debates regarding the interregional and interna- tional partnerships that constitute Great Britain, including those over Scottish Independence, EVEL (English Votes for English Laws) and proposed legislation on an ‘in/out’ referendum on British membership of the European Union, have contributed to, and intensified, the examination of Britain’s institutions, as well as its national emblems and arche- types. In light of such a dynamic situation, Visual Culture in Britain has asked representatives of British universities, the museum sector and research centres to respond to the idea of a changing Britain through the prism of British art and visual culture, using cogent examples wherever possible, and to outline their observations, understandings and positions within this rapidly developing context

Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B

Voltage-gated potassium channels (Kv) are important regulators of membrane potential in vascular smooth muscle cells, which is integral to controlling intracellular Ca2+ concentration and regulating vascular tone. Previous work indicates that Kv channels can be modulated by receptor-driven alterations of cyclic AMP-dependent protein kinase (PKA) activity. Here, we demonstrate that Kv channel activity is maintained by tonic activity of PKA. Whole-cell recording was used to assess the effect of manipulating PKA signalling on Kv and ATP-dependent K+ channels of rat mesenteric artery smooth muscle cells. Application of PKA inhibitors, KT5720 or H89, caused a significant inhibition of Kv currents. Tonic PKA-mediated activation of Kv appears maximal as application of isoprenaline (a β-adrenoceptor agonist) or dibutyryl-cAMP failed to enhance Kv currents. We also show that this modulation of Kv by PKA can be reversed by protein phosphatase 2B/calcineurin (PP2B). PKA-dependent inhibition of Kv by KT5720 can be abrogated by pre-treatment with the PP2B inhibitor cyclosporin A, or inclusion of a PP2B auto-inhibitory peptide in the pipette solution. Finally, we demonstrate that tonic PKA-mediated modulation of Kv requires intact caveolae. Pre-treatment of the cells with methyl-β-cyclodextrin to deplete cellular cholesterol, or adding caveolin-scaffolding domain peptide to the pipette solution to disrupt caveolae-dependent signalling each attenuated PKA-mediated modulation of the Kv current. These findings highlight a novel, caveolae-dependent, tonic modulatory role of PKA on Kv channels providing new insight into mechanisms and the potential for pharmacological manipulation of vascular tone

Probing Cosmic Reionization and Molecular Gas Growth with TIME

Line intensity mapping (LIM) provides a unique and powerful means to probe cosmic structures by measuring the aggregate line emission from all galaxies across redshift. The method is complementary to conventional galaxy redshift surveys that are object-based and demand exquisite point-source sensitivity. The Tomographic Ionized-carbon Mapping Experiment (TIME) will measure the star formation rate (SFR) during cosmic reionization by observing the redshifted [CII] 158$\mu$m line ($6 \lesssim z \lesssim 9$) in the LIM regime. TIME will simultaneously study the abundance of molecular gas during the era of peak star formation by observing the rotational CO lines emitted by galaxies at $0.5 \lesssim z \lesssim 2$. We present the modeling framework that predicts the constraining power of TIME on a number of observables, including the line luminosity function, and the auto- and cross-correlation power spectra, including synergies with external galaxy tracers. Based on an optimized survey strategy and fiducial model parameters informed by existing observations, we forecast constraints on physical quantities relevant to reionization and galaxy evolution, such as the escape fraction of ionizing photons during reionization, the faint-end slope of the galaxy luminosity function at high redshift, and the cosmic molecular gas density at cosmic noon. We discuss how these constraints can advance our understanding of cosmological galaxy evolution at the two distinct cosmic epochs for TIME, starting in 2021, and how they could be improved in future phases of the experiment.Comment: 30 pages, 18 figures, accepted for publication in Ap

The Mating Systems and Pollination Biology of Three Species of Verbena (Verbenaceae)

Because their flowers can be cross- and/or self-pollinated Verbena stricta, V hastata and V urticifolia are facultatively xenogamous. We suggest the flowers can be cross-pollinated because I) the fruit set of caged plants was substantially lower than that of open-pollinated plants, i.e. pollinators were necessary for typical fruit set and 2) the flowers of each species attracted a diverse array of hymenopteran, dipteran and lepidopteran pollinators that were capable of moving pollen between plants. Self-pollination was low due to the spatial separation of anthers and stigmas and/or an angled corolla that decreased the likelihood of pollen dropping from the anthers onto the stigma. However, the limited ability of flowers to self-pollinate was supplemented by the intrafloral movement of pollen by thrips. In addition, both the pollen-ovule ratios and pollination efficiencies of these species were consistent with those of other facultatively xenogamous species, and the available data were consistent with each species being self-compatible. Finally, we discuss a protocol for distinguishing between self-pollination and the intrafloral movement of pollen by thrips

Enhanced Brain Disposition and Effects of Δ9-Tetrahydrocannabinol in P-Glycoprotein and Breast Cancer Resistance Protein Knockout Mice

The ABC transporters P-glycoprotein (P-gp, Abcb1) and breast cancer resistance protein (Bcrp, Abcg2) regulate the CNS disposition of many drugs. The main psychoactive constituent of cannabis Δ9-tetrahydrocannabinol (THC) has affinity for P-gp and Bcrp, however it is unknown whether these transporters modulate the brain accumulation of THC and its functional effects on the CNS. Here we aim to show that mice devoid of Abcb1 and Abcg2 retain higher brain THC levels and are more sensitive to cannabinoid-induced hypothermia than wild-type (WT) mice. Abcb1a/b (−/−), Abcg2 (−/−) and wild-type (WT) mice were injected with THC before brain and blood were collected and THC concentrations determined. Another cohort of mice was examined for THC-induced hypothermia by measuring rectal body temperature. Brain THC concentrations were higher in both Abcb1a/b (−/−) and Abcg2 (−/−) mice than WT mice. ABC transporter knockout mice exhibited delayed elimination of THC from the brain with the effect being more prominent in Abcg2 (−/−) mice. ABC transporter knockout mice were more sensitive to THC-induced hypothermia compared to WT mice. These results show P-gp and Bcrp prolong the brain disposition and hypothermic effects of THC and offer a novel mechanism for both genetic vulnerability to the psychoactive effects of cannabis and drug interactions between CNS therapies and cannabis