Synthesis and Antiviral Evaluation of Bisnoradamantane Sulfites and Related Compounds

The reaction of a series of 1,2-diols with thionyl chloride led to bisnoradamantane sulfites in very good yields. The reaction has also been applied to related polycyclic scaffolds. The compounds have been tested for antiviral activity but none of them showed to be active. Several attempts to generate and trap SO from these polycyclic sulfites have been unsuccessful

SARS-CoV-2 Infection in Multiple Sclerosis: Results of the Spanish Neurology Society Registry

Esclerosis múltiple; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoVEsclerosi múltiple; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoVMultiple sclerosis; Coronavirus SARS-CoV-2; COVID-19; 2019-nCoVObjective To understand COVID-19 characteristics in people with multiple sclerosis (MS) and identify high-risk individuals due to their immunocompromised state resulting from the use of disease-modifying treatments. Methods Retrospective and multicenter registry in patients with MS with suspected or confirmed COVID-19 diagnosis and available disease course (mild = ambulatory; severe = hospitalization; and critical = intensive care unit/death). Cases were analyzed for associations between MS characteristics and COVID-19 course and for identifying risk factors for a fatal outcome. Results Of the 326 patients analyzed, 120 were cases confirmed by real-time PCR, 34 by a serologic test, and 205 were suspected. Sixty-nine patients (21.3%) developed severe infection, 10 (3%) critical, and 7 (2.1%) died. Ambulatory patients were higher in relapsing MS forms, treated with injectables and oral first-line agents, whereas more severe cases were observed in patients on pulsed immunosuppressors and critical cases among patients with no therapy. Severe and critical infections were more likely to affect older males with comorbidities, with progressive MS forms, a longer disease course, and higher disability. Fifteen of 33 patients treated with rituximab were hospitalized. Four deceased patients have progressive MS, 5 were not receiving MS therapy, and 2 were treated (natalizumab and rituximab). Multivariate analysis showed age (OR 1.09, 95% CI, 1.04–1.17) as the only independent risk factor for a fatal outcome. Conclusions This study has not demonstrated the presumed critical role of MS therapy in the course of COVID-19 but evidenced that people with MS with advanced age and disease, in progressive course, and those who are more disabled have a higher probability of severe and even fatal disease.This work was funded by the Spanish Society of Neurology for the writing, editorial assistance, statistical analysis and the Article Processing Charge. Other contributions related to financial support for writing, statistical analysis, and editorial assistance were supported by Biogen, Bristol-Myers Squibb, Merck, Roche, Sanofi, and Teva

Metabolomics of Ulva lactuca Linnaeus (Chlorophyta) exposed to oil fuels: Fourier transform infrared spectroscopy and multivariate analysis as tools for metabolic fingerprint

Fossil fuels, e.g. gasoline and diesel oil, account for substantial share of the pollution that affects marine ecosystems. Environmental metabolomics is an emerging field that may help unravel the effect of these xenobiotics on seaweeds and provide methodologies for biomonitoring coastal ecosystems. In the present study, FTIR and multivariate analysis were used to discriminate metabolic profiles of Ulva lactuca after in vitro exposure to diesel oil and gasoline, in combinations of concentrations (0.001%, 0.01%, 0.1%, and 1.0% - v/v) and times of exposure (30 min, 1 h, 12 h, and 24 h). PCA and HCA performed on entire mid-infrared spectral window were able to discriminate diesel oil-exposed thalli from the gasoline-exposed ones. HCA performed on spectral window related to the protein absorbance (17001500 cm 1) enabled the best discrimination between gasoline-exposed samples regarding the time of exposure, and between diesel oil-exposed samples according to the concentration. The results indicate that the combination of FTIR with multivariate analysis is a simple and efficient methodology for metabolic profiling with potential use for biomonitoring strategies.To Coordination for the Improvement of Higher Education Personnel (CAPES) for financial support. The research fellowships granted to Marcelo Maraschin (Proc. 307099/2015-6) and Fernanda Ramlov (Proc. 473408/2013-9) by National Council of Technological and Scientific Development (CNPq) are also acknowledged. This work was partially funded by CNPq and FCT agreement through the PropMine (Proc. 490383/2013-0) and PVE (Proc. 407323/2013-9, Dr. Miguel Rocha) grants

Preservação das áreas verdes urbanas: um estudo sobre o Parque Ecológico das Timbaúbas

Na medida em que a sociedade se apropria dos recursos naturais, transforma os espaços naturais em espaços artificiais, diminuindo o potencial da biodiversidade, principalmente pelo avanço da urbanização. Nesses ambientes há maior necessidade de criação de áreas verdes, como medida para mitigar os efeitos do aumento de temperatura e escassez de água, dada a sua importância no processo da educação. É nesse contexto que em Juazeiro do Norte, Ceará foi Instituído pelo decreto de lei municipal número 1.083 de 23 de março de 1995, o Parque Ecológico das Timbaúbas, adequando o incentivo baseado na lei Federal nº 9.985/2000, sobre as Unidades de Conservação. O estudo sobre a preservação das áreas verdes, sob o foco do citado parque, objetivou levantar informações sobre o seu funcionamento e identificar a sua importância ecológica na influência da qualidade de vida dos moradores de Juazeiro do Norte. Para tanto, a metodologia utilizada foi a observação de campo, entrevista aberta com funcionários e educadores do parque, registro fotográfico, leituras e interpretações bibliográficas. O Parque se enquadra na classificação de Unidade de Proteção Integral, é um importante refúgio da caatinga, reserva alimentar para população do entorno, ambiente educativo e de lazer, entre outras funções. A área demarcada, 60 hectares, garante permeabilidade para alimentação do lençol freático pertencente à Bacia do Rio Salgado, fonte para o abastecimento de água da cidade. A concreta valorização do Parque das Timbaúbas, pelo poder público, privado e sociedade civil, exige parcerias no fortalecimento de suas ações, buscando alcançar novos caminhos

Banho de chuveiro como estratégia não farmacológica no alívio da dor de parturientes

O objetivo do estudo foi avaliar a efetividade do banho de chuveiro para o alívio da dor de parturientes na fase ativa do trabalho de parto. Estudo delineado como ensaio clínico do tipo intervenção terapêutica “antes e após”, realizado na Unidade de Parto Humanizado da Maternidade Escola Januário Cicco da Universidade Federal do Rio Grande do Norte, em Natal/RN, com 100 parturientes na aplicação dessa estratégia no período de setembro de 2005 a fevereiro de 2006. Para avaliar a intensidade da dor das parturientes utilizou-se a escala analógica visual. A maioria das parturientes do estudo estava na faixa etária entre 20 a 30 anos (60%), ensino fundamental incompleto (85%), renda familiar até 2 salários mínimos (74%) e 78% tinham um acompanhante, e destes, 44% era o próprio companheiro. A ocitocina foi administrada em 81% dos casos e apenas 15% dessas mulheres não receberam qualquer medicação. Verificou-se alívio significativo da dor na aplicação do banho de chuveiro, sendo efetivo no alívio da dor das parturientes do estudo

Effects designing image and thinking the body in different spaces / Projetando imagem e pensando o corpo nos diferentes espaços

Objetivos: Produzir diálogos a partir da criação de um desenho individual sobre a percepção do próprio corpo como elemento do cuidado em saúde; situar o corpo no espaço institucional e discutir coletivamente sua ocupação nos campos de atuação profissional, político e de poder. Método: Produção lúdica em sala de aula em curso de doutorado, com enfermeiros, médico, engenheiro e fisioterapeutas, no primeiro semestre de 2016. Se efetuou análise de conteúdo. Resultados: O corpo gera fluxos, sensibilidade, território e imaginação. Emergiram as categorias: psicodinâmica, psicopatogenia, metamorfose e desejo. Reconhecem a importância de transitar nos três campos, predominando 93% no espaço profissional, 53% no político e 53% no de poder. Alguns optaram por dois espaços simultaneamente e não houve nova criação. Conclusão: A estratégia do brincar para ensinar no ambiente dialógico permitiu participação ativa e redimensionou o pensar necessário à ocupação e desocupação dos espaços transversais no trabalho

PROCES KSZTAŁCENIA W ZAKRESIE PROFILAKTYKI I KONTROLI ZAKAŻEŃ ZWIĄZANYCH Z OPIEKĄ ZDROWOTNĄ W EUROPEJSKICH INSTYTUCJACH SZKOLNICTWA WYŻSZEGO – BADANIE JAKOŚCIOWE

[EN] Healthcare-associated infections (HCAIs) affect the lives of patients through prolonged stay in hospital, illness, or even death, incurring signifi cant costs to both healthcare systems and society. Research shows that during a stay in a hospital, approximately 20% to 30% of patients are diagnosed with at least one infection. Openness, fi ne interpersonal and communication skills as well as adequate opportunities for training courses for healthcare staff contribute to promoting HCAI/HAI prevention. HCAI/HAI-related education should contribute to widening knowledge and mastering practical skills. It is assumed that lecturers, professional instructors, and coordinators create a signifi cant foundation for professional development and social interactions by applying interactive pedagogical models. [POL] Zakażenia związane z opieką zdrowotną (Healthca- re associated infections, HCAI) wpływają na życie pacjentów poprzez przedłużony pobyt w szpitalu, chorobę, a nawet śmierć, powodując znaczne koszty zarówno dla systemów opieki zdrowotnej, jak i spo- łeczeństwa. Badania pokazują, że podczas pobytu w szpitalu u około 20% do 30% pacjentów diagnozuje się co najmniej jedną infekcję Otwarte podejście, wysokie umiejętności interpersonalne i komu- nikacyjne, a także odpowiednie możliwości szkoleń dla personelu medycznego przyczyniają się do promowania profi laktyki HCAI/ HAI. Kształcenie w zakresie HCAI/HAI powinno przyczynić się do poszerzenia wiedzy i opanowania praktycznych umiejętności. Zakłada się, że wykładowcy, profesjonalni instruktorzy, koordy- natorzy tworzą istotne podstawy rozwoju zawodowego i interakcji społecznych poprzez stosowanie interaktywnych modeli pedago- gicznych

Nursing Students' Perceptions on Healthcare-Associated Infection Control and Prevention Teaching and Learning Experience: Development and Validation of a Scale in Four European Countries

Healthcare-associated infections are one of the major concerns worldwide. This study presents the development and the validation process of the InovSafeCare scale and aimed at identifying and measuring the ecosystem variables related to healthcare-associated infection (HCAI) prevention and control practices in European nurse students. Qualitative and quantitative approaches were used to (1) elaborate an item pool related to the educational environment, the healthcare setting environment, and the attitudes, beliefs, and performance of the nursing students regarding HCAI prevention and control and (2) analyze psychometric properties of the scale using factor analysis. The validated InovSafeCare scale was applied to undergraduate nursing students of five European Higher Education Institutions. The partial least square structural equation modeling (PLS-SEM) method with SMART-PLS3 software was used. The study sample consists of 657 nursing students, who responded a self-report inventory. From the analyzed data were identified 14 factors. The InovSafeCare scale reveals good validity and reliability of the dimensions in different European countries.info:eu-repo/semantics/publishedVersio

Nursing Students' Perceptions on Healthcare-Associated Infection Control and Prevention Teaching and Learning Experience: Development and Validation of a Scale in Four European Countries

[EN] Healthcare-associated infections are one of the major concerns worldwide. This study presents the development and the validation process of the InovSafeCare scale and aimed at identifying and measuring the ecosystem variables related to healthcare-associated infection (HCAI) prevention and control practices in European nurse students. Qualitative and quantitative approaches were used to (1) elaborate an item pool related to the educational environment, the healthcare setting environment, and the attitudes, beliefs, and performance of the nursing students regarding HCAI prevention and control and (2) analyze psychometric properties of the scale using factor analysis. The validated InovSafeCare scale was applied to undergraduate nursing students of five European Higher Education Institutions. The partial least square structural equation modeling (PLS-SEM) method with SMART-PLS3 software was used. The study sample consists of 657 nursing students, who responded a self-report inventory. From the analyzed data were identified 14 factors. The InovSafeCare scale reveals good validity and reliability of the dimensions in different European countries

Nursing Students’ Perceptions on Healthcare-Associated Infection Control and Prevention Teaching and Learning Experience in Portugal

Healthcare-associated infections (HAI) are one of the major concerns worldwide, posing significant challenges to healthcare professionals’ education and training. This study intended to measure nursing students’ perceptions regarding their learning experiences on HAI prevention and control. In the first phase of the study, a cross-sectional and descriptive study with a convenience sample composed of undergraduate nursing students from Portugal, Spain, Poland, and Finland was conducted to develop the InovSafeCare questionnaire. In the second phase, we applied the InovSafeCare scale in a sample of nursing students from two Portuguese higher education institutions to explore which factors impact nursing students’ adherence to HAI prevention and control measures in clinical settings. In phase one, the InovSafeCare questionnaire was applied to 1326 students internationally, with the instrument presenting adequate psychometric qualities with reliability results in 14 dimensions. During phase two, the findings supported that Portuguese nursing students’ adherence to HAI prevention and control measures is influenced not only by the curricular offerings and resources available in academic settings, but also by the standards conveyed by nursing tutors during clinical placements. Our findings support the need for a dedicated curricular focus on HAI prevention and control learning, not only through specific classroom modules, innovative resources, and pedagogical approaches, but also through a complementary and coordinated liaison between teachers and tutors in academic and clinical settings.info:eu-repo/semantics/publishedVersio