Plasma Equilibrium inside Various Cross-Section Capillary Discharges

Plasma properties inside a hydrogen-filled capillary discharge waveguide were modeled with dissipative magnetohydrodynamic simulations to enable analysis of capillaries of circular and square cross-sections implying that square capillaries can be used to guide circularly-symmetric laser beams. When the quasistationary stage of the discharge is reached, the plasma and temperature in the vicinity of the capillary axis has almost the same profile for both the circular and square capillaries. The effect of cross-section on the electron beam focusing properties were studied using the simulation-derived magnetic field map. Particle tracking simulations showed only slight effects on the electron beam symmetry in the horizontal and diagonal directions for square capillary.Comment: 6 pages, 10 figure

Experimental investigation of fast electron transport in solid density matter: Recent results from a new technique of X-ray energy-encoded 2D imaging

AbstractThe development activity of a new experimental technique for the study of the fast electron transport in high density matter is reported. This new diagnostic tool enables the X-ray 2D imaging of ultrahigh intensity laser plasmas with simultaneous spectral resolution in a very large energy range to be obtained. Results from recent experiments are discussed, in which the electron propagation in multilayer targets was studied by using the Kα. In particular, results highlighting the role of anisotropic Bremsstrahlung are reported, for the sake of the explanation of the capabilities of the new diagnostics. A discussion of a test experiment conceived to extend the technique to a single-shot operation is finally given

HELL: High-energy electrons by laser light, a user-oriented experimental platform at ELI beamlines

Laser wake field acceleration (LWFA) is an efficient method to accelerate electron beams to high energy. This is a benefit in research infrastructures where a multidisciplinary environment can benefit from the different secondary sources enabled, having the opportunity to extend the range of applications that is accessible and to develop new ideas for fundamental studies. The ELI Beamline project is oriented to deliver such beams to the scientific community both for applied and fundamental research. The driver laser is a Ti:Sa diode-pumped system , running at a maximum performance of 10 Hz, 30 J, and 30 fs. The possibilities to setup experiments using different focal lengths parabolas, as well as the possibility to counter-propagate a second laser beam intrinsically synchronized, are considered in the electron acceleration program. Here, we review the laser-driven electron acceleration experimental platform under implementation at ELI Beamlines, the HELL (High-energy Electrons by Laser Light) experimental platform

Non-adiabatic cluster expansion after ultrashort laser interaction

AbstractWe used X-ray spectroscopy as a diagnostic tool for investigating the properties of laser-cluster interactions at the stage in which non-adiabatic cluster expansion takes place and a quasi-homogeneous plasma is produced. The experiment was carried out with a 10 TW, 65 fs Ti:Sa laser focused on CO2 cluster jets. The effect of different laser-pulse contrast ratios and cluster concentrations was investigated. The X-ray emission associated to the Rydberg transitions allowed us to retrieve, through the density and temperature of the emitting plasma, the time after the beginning of the interaction at which the emission occurred. The comparison of this value with the estimated time for the "homogeneous" plasma formation shows that the degree of adiabaticity depends on both the cluster concentration and the pulse contrast. Interferometric measurements support the X-ray data concerning the plasma electron density

Fast decomposed method to devise broadband polarization-conversion metasurface

9 pags., 5 figs., 1 tab.Designing a broadband, wide-angle, and high-efficient polarization converter with a simple geometry remains challenging. This work proposes a simple and computationally inexpensive method for devising broadband polarization conversion metasurfaces. We focus on a cross-shape configuration consisting of two bars of different lengths connected at the center. To design the metasurface, we decompose the system into two parts with two orthogonally polarized responses and calculate the response of each part separately. By selecting the parameters with a proper phase difference in the response between the two parts, we can determine the dimensions of the system. For designing broadband polarization conversion metasurfaces, we define a fitness function to optimize the bandwidth of the linear polarization conversion. Numerical results demonstrate that the proposed method can be used to design a metasurface that achieves a relative bandwidth of [Formula: see text] for converting linearly polarized waves into cross-polarized waves. Additionally, the average polarization conversion ratio of the designed metasurface is greater than [Formula: see text] over the frequency range of 10.9-28.5 GHz. This method significantly reduces the computational expense compared to the traditional method and can be easily extended to other complex structures and configurations.Peer reviewe

3D-Printed Microcubes for Catalase Drug Delivery

Oxidative stress, i.e., excessive production of reactive oxygen species (ROS), plays an important role in the pathogenesis of inflammatory diseases such as cardiovascular diseases, cancer, and neurodegenerative diseases. Catalase, an antioxidant enzyme, has great therapeutic potential; however, its efficacy is limited by its delivery to target cells or tissues. In order to achieve efficient delivery, consistent drug distribution, and drug activity, small and uniformly sized drug delivery vehicles are needed. Here, three-dimensional (3D) microcubes were printed by Nanoscribe Photonic Professional GT2, a high-resolution 3D printer, and the characteristics of 3D-printed microcubes as drug delivery vehicles for the delivery of catalase were investigated. The size of the 3D-printed microcubes was 800 nm in length of a square and 600 nm in height, which is suitable for targeting macrophages passively. Microcubes were also tunable in shape and size, and high-resolution 3D printing could provide microparticles with little variation in shape and size. Catalase was loaded on 3D-printed microcubes by nonspecific adsorption, and catalase on 3D-printed microcubes (CAT–MC) retained 83.1 ± 1.3% activity of intact catalase. CAT–MC also saved macrophages, RAW 264.7, from the cytotoxicity of H2O2 by 86.4 ± 4.1%. As drug delivery vehicles, 3D-printed microparticles are very promising due to their small and uniform size, which provides consistent drug distribution and drug activity. Therefore, we anticipate numerous applications of 3D-printed microparticles for delivering therapeutic proteins

Plasmonic Polarization Rotation in SERS Spectroscopy

International audienceSurface-enhanced Raman optical activity (SEROA) has been extensively investigated due to its ability to directly probe stereochemistry and molecular structure. However, most works have focused on the Raman optical activity (ROA) effect arising from the chirality of the molecules on isotropic surfaces. Here, we propose a strategy for achieving a similar effect: i.e., a surface-enhanced Raman polarization rotation effect arising from the coupling of optically inactive molecules with the chiral plasmonic response of metasurfaces. This effect is due to the optically active response of metallic nanostructures and their interaction with molecules, which could extend the ROA potential to inactive molecules and be used to enhance the sensibility performances of surface-enhanced Raman spectroscopy. More importantly, this technique does not suffer from the heating issue present in traditional plasmonic-enhanced ROA techniques, as it does not rely on the chirality of the molecules

Experimental Study of Nanosecond Laser-Generated Plasma Channels

Generation of plasma-channels by interaction of gas targets with nanosecond laser beams was investigated experimentally. Such laser-generated plasma channels are very promising for subsequent guiding of high peak power femtosecond laser pulses, over several tens of centimeters, as required in laser wake field electron-acceleration (LWFA). The experimental setup was based on the use of a cylindrical lens (100 mm of focal length) with the aim of proposing a technical solution easy to be integrated into a compact experimental setup for acceleration of multi-GeV electron beams using high peak-power laser systems. A pilot experiment, showing production of asymmetric plasma channels over a length of several millimeters in N and Ar targets with initial neutral-gas atomic density around 5 × 1019 cm−3, is reported. Plasma effective threshold formation was estimated, along with future optimization of the optical setup for a symmetrization of such plasma channel. Scalability of this concept to several tens of centimeters is preliminarily discussed, along with the corresponding critical requirements for an optimal LWFA scheme