First detection of the outer edge of an AGN accretion disc: very fast multiband optical variability of NGC 4395 with GTC/HiPERCAM and LT/IO:O

We present fast (∼200 s sampling) ugriz photometry of the low -mass AGN NGC 4395 with the Liverpool Telescope, followed by very fast (3 s sampling) us, gs, rs, is, and zs simultaneous monitoring with HiPERCAM on the 10.4m GTC. These observations provide the fastest ever AGN multiband photometry and very precise lag measurements. Unlike in all other AGN, gs lags us by a large amount, consistent with disc reprocessing but not with reprocessing in the broad-line region (BLR). There is very little increase in lag with wavelength at long wavelengths, indicating an outer edge (Rout) to the reprocessor. We have compared truncated disc reprocessing models to the combined HiPERCAM and previous X-ray/UV lags. For the normally accepted mass of 3.6 × 105M⊙, we obtain reasonable agreement with zero spin, Rout ∼ 1700Rg and the DONE physically motivated temperature-dependent disc colour-correction factor (fcol ⁠). A smaller mass of 4 × 104M⊙ can only be accommodated if fcol=2.4⁠, which is probably unrealistically high. Disc self gravity is probably unimportant in this low-mass AGN but an obscuring wind may provide an edge. For the small mass, the dust sublimation radius is similar to Rout so the wind could be dusty. However, for the more likely large mass, the sublimation radius is further out so the optically thick base of a line-driven gaseous wind is more likely. The inner edge of the BLR is close to Rout in both cases. These observations provide the first good evidence for a truncated AGN disc and caution that truncation should be included in reverberation lag modelling

Sterility of gamma-irradiated pathogens: a new mathematical formula to calculate sterilizing doses

In recent years there has been increasing advocacy for highly immunogenic gamma-irradiated vaccines, several of which are currently in clinical or pre-clinical trials. Importantly, various methods of mathematical modelling and sterility testing are employed to ensure sterility. However, these methods are designed for materials with a low bioburden, such as food and pharmaceuticals. Consequently, current methods may not be reliable or applicable to estimate the irradiation dose required to sterilize microbiological preparations for vaccine purposes, where bioburden is deliberately high. In this study we investigated the applicability of current methods to calculate the sterilizing doses for different microbes. We generated inactivation curves that demonstrate single-hit and multiple-hit kinetics under different irradiation temperatures for high-titre preparations of pathogens with different genomic structures. Our data demonstrate that inactivation of viruses such as Influenza A virus, Zika virus, Semliki Forest virus and Newcastle Disease virus show single-hit kinetics following exposure to gamma-irradiation. In contrast, rotavirus inactivation shows multiple-hit kinetics and the sterilizing dose could not be calculated using current mathematical methods. Similarly, Streptococcus pneumoniae demonstrates multiple-hit kinetics. These variations in killing curves reveal an important gap in current mathematical formulae to determine sterility assurance levels. Here we propose a simple method to calculate the irradiation dose required for a single log₁₀ reduction in bioburden (D₁₀) value and sterilizing doses, incorporating both single- and multiple-hit kinetics, and taking into account the possible existence of a resistance shoulder for some pathogens following exposure to gamma-irradiation.Eve V. Singleton, Shannon C. David, Justin B. Davies, Timothy R. Hirst, James C. Paton, Michael R. Beard, Farhid Hemmatzadeh, and Mohammed Alsharif

First detection of the outer edge of an AGN accretion disc: Very fast multiband optical variability of NGC 4395 with GTC/HiPERCAM and LT/IO:O

We present fast (~200s sampling) ugriz photometry of the low mass AGN NGC 4395 with the Liverpool Telescope, followed by very fast (3s sampling) us, gs, rs, is and zs simultaneous monitoring with HiPERCAM on the 10.4m GTC. These observations provide the fastest ever AGN multiband photometry and very precise lag measurements. Unlike in all other AGN, gs lags us by a large amount, consistent with disc reprocessing but not with reprocessing in the Broad Line Region (BLR). There is very little increase in lag with wavelength at long wavelengths, indicating an outer edge (Rout) to the reprocessor. We have compared truncated disc reprocessing models to the combined HiPERCAM and previous X-ray/UV lags. For the normally accepted mass of 3.6E5 solar, we obtain reasonable agreement with zero spin, Rout ~1700 Rg, and the DONE physically-motivated temperature-dependent disc colour correction factor (fcol). A smaller mass of 4E4 solar can only be accomodated if fcol=2.4, which is probably unrealistically high. Disc self gravity is probably unimportant in this low mass AGN but an obscuring wind may provide an edge. For the small mass the dust sublimation radius is similar to Rout, so the wind could be dusty. However for the more likely large mass the sublimation radius is further out so the optically-thick base of a line-driven gaseous wind is more likely. The inner edge of the BLR is close to Rout in both cases. These observations provide the first good evidence for a truncated AGN disc and caution that truncation should be included in reverberation lag modelling

ULTRACAM: an ultrafast, triple-beam CCD camera for high-speed astrophysics

ULTRACAM is a portable, high-speed imaging photometer designed to study faint astronomical objects at high temporal resolutions. ULTRACAM employs two dichroic beamsplitters and three frame-transfer CCD cameras to provide three-colour optical imaging at frame rates of up to 500 Hz. The instrument has been mounted on both the 4.2-m William Herschel Telescope on La Palma and the 8.2-m Very Large Telescope in Chile, and has been used to study white dwarfs, brown dwarfs, pulsars, black hole/neutron star X-ray binaries, gamma-ray bursts, cataclysmic variables, eclipsing binary stars, extrasolar planets, flare stars, ultracompact binaries, active galactic nuclei, asteroseismology and occultations by Solar System objects (Titan, Pluto and Kuiper Belt objects). In this paper we describe the scientific motivation behind ULTRACAM, present an outline of its design and report on its measured performance

Can consumers enforce environmental regulations? The role of the market in hazardous waste compliance

We examine the U.S. hazardous waste management industry to assess the role that consumers play in encouraging environmental compliance. We first examine whether environmental performance affects consumer demand and find that noncompliance does decrease demand, at least in the short term. Next we consider whether market characteristics affect compliance behavior. While we do not find evidence that market size affects behavior, local competition does appear to increase compliance. However, as competition becomes less localized, it has a smaller effect. Finally, regardless of the pressures exerted by consumers to comply, commercial managers are less likely to be in compliance than on-site managers. Copyright Springer Science+Business Media, LLC 2007Commercial environmentalism, Compliance, Enforcement, Hazardous waste, Market size, Competition, Q28, K42, D21,