Community structures and role detection in music networks

We analyze the existence of community structures in two different social networks obtained from similarity and collaborative features between musical artists. Our analysis reveals some characteristic organizational patterns and provides information about the driving forces behind the growth of the networks. In the similarity network, we find a strong correlation between clusters of artists and musical genres. On the other hand, the collaboration network shows two different kinds of communities: rather small structures related to music bands and geographic zones, and much bigger communities built upon collaborative clusters with a high number of participants related through the period the artists were active. Finally, we detect the leading artists inside their corresponding communities and analyze their roles in the network by looking at a few topological properties of the nodes.Comment: 14 pages 7 figure

Analysis, design, and prototype development of squeeze-film bearings for AB-5 gyro Final report phase 2, design, fabrication and evaluation of prototypes

Squeeze-film bearing transducers with piezoceramic cylinders for AB-5 gyro - design, fabrication, and testing of cylindrical journal and annular bearing prototype

Effect of helicity and rotation on the free decay of turbulent flows

The self-similar decay of energy in a turbulent flow is studied in direct numerical simulations with and without rotation. Two initial conditions are considered: one non-helical (mirror-symmetric), and one with maximal helicity. The results show that, while in the absence of rotation the energy in the helical and non-helical cases decays with the same rate, in rotating flows the helicity content has a major impact on the decay rate. These differences are associated with differences in the energy and helicity cascades when rotation is present. Properties of the structures that arise in the flow at late times in each time are also discussed.Comment: 4 pages, 4 figure

RANKL Employs Distinct Binding Modes to Engage RANK and the Osteoprotegerin Decoy Receptor

SummaryOsteoprotegerin (OPG) and receptor activator of nuclear factor κB (RANK) are members of the tumor necrosis factor receptor (TNFR) superfamily that regulate osteoclast formation and function by competing for RANK ligand (RANKL). RANKL promotes osteoclast development through RANK activation, while OPG inhibits this process by sequestering RANKL. For comparison, we solved crystal structures of RANKL with RANK and RANKL with OPG. Complementary biochemical and functional studies reveal that the monomeric cytokine-binding region of OPG binds RANKL with ∼500-fold higher affinity than RANK and inhibits RANKL-stimulated osteoclastogenesis ∼150 times more effectively, in part because the binding cleft of RANKL makes unique contacts with OPG. Several side chains as well as the C-D and D-E loops of RANKL occupy different orientations when bound to OPG versus RANK. High affinity OPG binding requires a 90s loop Phe residue that is mutated in juvenile Paget’s disease. These results suggest cytokine plasticity may help to fine-tune specific tumor necrosis factor (TNF)-family cytokine/receptor pair selectivity

Cardiovascular Disease Mortality Among Breast Cancer Survivors

Cardiovascular disease (CVD) is of increasing concern among breast cancer survivors. However the burden of this comorbidity in this group relative to the general population, and its temporal pattern, remains unknown

A bone to pick-cellular and molecular mechanisms of bone pain in sickle cell disease

The bone is one of the most commonly affected organs in sickle cell disease (SCD). Repeated ischemia, oxidative stress and inflammation within the bone is largely responsible for promoting bone pain. As more individuals with SCD survive into adulthood, they are likely to experience a synergistic impact of both aging and SCD on their bone health. As bone health deteriorates, bone pain will likely exacerbate. Recent mechanistic and observational studies emphasize an intricate relationship between bone remodeling and the peripheral nervous system. Under pathological conditions, abnormal bone remodeling plays a key role in the propagation of bone pain. In this review, we first summarize mechanisms and burden of select bone complications in SCD. We then discuss processes that contribute to pathological bone pain that have been described in both SCD as well as non-sickle cell animal models. We emphasize the role of bone-nervous system interactions and pitfalls when designing new therapies especially for the sickle cell population. Lastly, we also discuss future basic and translational research in addressing questions about the complex role of stress erythropoiesis and inflammation in the development of SCD bone complications, which may lead to promising therapies and reduce morbidity in this vulnerable population

Crossover from Rate-Equation to Diffusion-Controlled Kinetics in Two-Particle Coagulation

We develop an analytical diffusion-equation-type approximation scheme for the one-dimensional coagulation reaction A+A->A with partial reaction probability on particle encounters which are otherwise hard-core. The new approximation describes the crossover from the mean-field rate-equation behavior at short times to the universal, fluctuation-dominated behavior at large times. The approximation becomes quantitatively accurate when the system is initially close to the continuum behavior, i.e., for small initial density and fast reaction. For large initial density and slow reaction, lattice effects are nonnegligible for an extended initial time interval. In such cases our approximation provides the correct description of the initial mean-field as well as the asymptotic large-time, fluctuation-dominated behavior. However, the intermediate-time crossover between the two regimes is described only semiquantitatively.Comment: 21 pages, plain Te

On Induced Gravity in 2-d Topological Theories

We study 2-d $\phi F$ gauge theories with the objective to understand, also at the quantum level, the emergence of induced gravity. The wave functionals - representing the eigenstates of a vanishing flat potential - are obtained in the $\phi$ representation. The composition of the space they describe is then analyzed: the state corresponding to the singlet representation of the gauge group describes a topological universe. For other representations a metric which is invariant under the residual gauge group is induced, apart from possible topological obstructions. Being inherited from the group metric it is rather rigid.Comment: 38, tex, 160/93/e

Interpocket polarization model for magnetic structures in rare-earth hexaborides

The origin of peculiar magnetic structures in cubic rare-earth (R) hexaborides RB_6 is traced back to their characteristic band structure. The three sphere-like Fermi surfaces induce interpocket polarization of the conduction band as a part of a RKKY-type interaction. It is shown for the free-electron-like model that the interpocket polarization gives rise to a broad maximum in the intersite interaction I(q) around q=(1/4,1/4,1/2) in the Brillouin zone. This maximum is consistent with the superstructure observed in R=Ce, Gd and Dy. The wave-number dependence of I(q) is independently extracted from analysis of the spin-wave spectrum measured for NdB_6. It is found that I(q) obtained from fitting the data has a similarly to that derived by the interpocket polarization model, except that the absolute maximum now occurs at (0,0,1/2) in consistency with the A-type structure. The overall shape of I(q) gives a hint toward understanding an incommensurate structure in PrB_6 as well.Comment: 5 pages, 3 figures, submitted to J.Phys.Soc.Jp