Topographic conditions and physical activity behaviour of young adults in Austria

In Austria there is an east-west divide concerning the amount of physical activity that has been detected. This is associated with poorer health in the eastern region of Austria compared to the western. Experts think that differences in topographic conditions might be a reason for these differences. However this hypothesis until now has not been scientifically proven. This study incorporates a multi-staged approach. First, outdoor physical activity behaviour (levels of exercise, favourite activities etc.) among people aged between 18-35 and living in Burgenland (n=150), as well as levels of physical activity in general, were compared with those of people at the same age living in Tyrol (n=150), by using a semi-standardized quantitative online-survey. To determine if differences between these two groups were significant the chi-squared test was used. In addition satisfaction with opportunities for outdoor physical exercise, motives, barriers and wishes concerning design of green spaces were analysed. Finally experts, working in the field of physical activity promotion (n=9), discussed within a focus group how to implement results into practice. The hypothesis that topographic conditions have an influence on physical activity behaviour was confirmed. For example, people living in Tyrol are more likely to engage in mountain sports than those living in Burgenland, while Nordic Walking is more popular in Burgenland compared to Tyrol (P<0.05). The results also show that people living in Tyrol are more physically active in general (P<0.05) as well as do more outdoor sport than people living in Burgenland (P<0.05). In addition some barriers as well as need for action could be identified in both regions. The natural environment influences levels of physical activity as well as sport activities among local populations. However differences in topographic conditions are not like to be the only reason for east-west differences concerning levels and forms of physical activity. Expert recommendations need to be implemented in the future. Further research needs to be conducted to examine the role of other potential explanations for east-west differences

HIV-fertőzött személyek neurokognitív eltérései - hazai prevalenciavizsgálat előzetes eredményei

BACKGROUND AND PURPOSE: The outcome of HIV infection has dramatically improved due to the widespread use of combined antiretroviral therapy (cART). Opportunistic infections faded and internal and hemato-oncological diseases along with neurological conditions came to the forth. Present study is to evaluate neurocognitive performance of the Hungarian HIV infected individuals, at first in this setting Patients and methods - We performed this cross-sectional pilot study within the frames of a national, single-center; prospective study on group of HIV infected patients, analyzing medical data and neurocognitive performance. Based on international recommendations visual memory, visuomotor coordination, non-verbal learning ability, executive functions and reaction time were tested by six domains of a computerized neuropsychological test battery (Vienna Test System). RESULTS: Data of 59 enrolled HIV individuals were analysed; nine of whom were women (15%), median age 42.6 (IQR: 32.4-48.1) years. In 32.2% (n=19) of patients neurocognitive impairment was detected. Duration of infection and cART treatment time tended to be longer in impaired group (not significant). Lower CD4 cell count at the time of examination (p=0.047), psychiatric diseases other than depression (p=0.005) were found significantly associated with impairment; tertiary education qualification were more common (p=0.033) among non-affected patients. By correlation analysis age, infected time and duration of cART were significantly associated with motor deficit. CONCLUSION: HAND was detected in almost one third part of examined patients, which largely corresponds that in developed countries were observed. Duration of infection and of cART therapy associated motor deficit was found to be the most common impairment. This finding might be interpreted by direct effect of HIV, neurotoxicity of antiretro virals and also by accelerated ageing of this population

Smarter in the city? Lizards from urban and semi-natural habitats do not differ in a cognitive task in two syntopic species.

Urbanization occurs at a global scale, imposing dramatic and abrupt environmental changes that lead to biodiversity loss. Yet, some animal species can handle these changes, and thrive in such artificial environments. One possible explanation is that urban individuals are equipped with better cognitive abilities, but most studies have focused on birds and mammals and yielded varied results. Reptiles have received much less attention, despite some lizard species being common city dwellers. The Italian wall lizard, Podarcis siculus, and the common wall lizard, Podarcis muralis, are two successful lizards in anthropogenic habitats that thrive in urban locations. To test for differences in a cognitive skill between urban and semi-natural environments, we investigated inhibitory control through a detour task in syntopic populations of the two species, across 249 lizards that were tested in partially artificial field settings. Sophisticated inhibitory control is considered essential for higher degrees of cognitive flexibility and other higher-level cognitive abilities. In this task, we confronted lizards with a transparent barrier, separating them from a desired shelter area that they could only reach by controlling their impulse to go straight and instead detour the barrier. We found no differences between lizards in urban and semi-natural environments, nor between species, but females overall performed better than males. Moreover, 48% of the lizards in our study did not perform a correct trial in any of the 5 trials, hinting at the difficulty of the task for these species. This study is among the first to address lizard cognition, through their inhibitory control, as a potential explanation for success in cities and highlights one should be careful with assuming that urban animals generally have enhanced cognitive performance, as it might be taxa, task, or condition dependent

Characteristics of Cultivated Adult Human Nevocellular Nevus Cells

Nevus cells are of biologic interest because of their uncertain relationship to epidermal melanocytes and of clinical interest because of their statistical association with melanoma. We report a technique that allows reliable cultivation of nevus cells from small acquired and congenital nevi and permits in vitro characterization of this cell type. Morphologically, cultured nevus cells were found to closely resemble epidermal melanocytes from the same or comparably aged donors, manifesting marked dendricity and specific ultrastructural features characteristic of melanocytes; but could be distinguished by the presence of occasional large binucleate or trinucleate cells and by the frequent finding of grouped melanosomes in nevus cell cytoplasm. Growth kinetics were also similar for nevus cells and epidermal melanocytes, with population doubling times of 1-2 weeks in hormone-supplemented serum-fre-medium, and substantial growth enhancement by fetal bovine serum. As previously noted for epidermal melanocytes, nevus cells in serum-free culture demonstrated striking substrate responsiveness, with far greater attachment rates and degree of cytoplasmic spreading on fibronectin or type I/III collagen than on laminin, type IV collage, or uncoated plastic. These strong similarities in vitro suggest that morphologic and behavioral differences observed between epidermal melanocytes and nevus cells in the skin may result from local environmental influences rather than from intrinsic cellular differences. The availability of a satisfactory culture system for nevus cells may facilitate future investigations into their malignant potential and other biologic features

Making SDGs work for climate change hotspots

The impacts of climate change on people's livelihoods have been widely documented. It is expected that climate and environmental change will hamper poverty reduction, or even exacerbate poverty in some or all of its dimensions. Changes in the biophysical environment, such as droughts, flooding, water quantity and quality, and degrading ecosystems, are expected to affect opportunities for people to generate income. These changes, combined with a deficiency in coping strategies and innovation to adapt to particular climate change threats, are in turn likely to lead to increased economic and social vulnerability of households and communities, especially amongst the poorest

Controlled exercise as a tool for preventing obesity and metabolic diseases in Arg64 carrier women.

Genética y ejercicio

Accelerating progress towards the Zero Hunger Goal in cross-boundary climate change hotspots

The most recent 2017 United Nations’ Sustainable Development Goals progress report highlighted the need to accelerate the pace of progress in order for the Sustainable Development Goals to be fully achieved. Responding to these concerns, the present commen tary proposes four distinct, but interrelated approaches to accelerate the Zero Hunger G oal in transboundary climate change hotspots, regions which suffer from multiple stressors and vulnerabilities, and in which prevalence of food insecurity and malnutrition often remains disproportionately high. These conceptual, programmatic and policy approaches are discussed drawing from a newly developed conceptual framework and referring to specific examples from climate change hotspots around the world

Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention

The ?-2 and ?-3 adrenergic receptors (ADRB2 and ADRB3) are thought to play a role in energy expenditure and lipolysis. However, the effects of the ADRB2 glutamine (Gln) 27 glutamic acid (glutamate) (Glu) and ADRB3 tryptophan (Trp) 64 arginine (Arg) polymorphisms on weight loss remain controversial. The aim of this study was to investigate the effect of these polymorphisms on changes in weight and body composition during a controlled weight-loss program. One hundred seventy-three healthy overweight and obese participants (91 women, 82 men) aged 18?50 years participated in a 22-week-long intervention based on a hypocaloric diet and exercise. They were randomly assigned to 1 of 4 groups: strength, endurance, strength and endurance combined, and physical activity recommendations only. Body weight, body mass index (BMI), and body composition variables were assessed before and after the intervention. Genetic analysis was carried out according to standard protocols. No effect of the ADRB2 gene was shown on final weight, BMI, or body composition, although in the supervised male group, Glu27 carriers tended to have greater weight (p = 0.019, 2.5 kg) and BMI (p = 0.019, 0.88 kg/m2) reductions than did noncarriers. There seems to be an individual effect of the ADRB3 polymorphism on fat mass (p = 0.004) and fat percentage (p = 0.036), in addition to an interaction with exercise for fat mass (p = 0.038). After the intervention, carriers of the Arg64 allele had a greater fat mass and fat percentage than did noncarriers (p = 0.004, 2.8 kg). In conclusion, the ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms may influence weight loss and body composition, although the current evidence is weak; however, further studies are necessary to clarify their roles

Analiza metod diagnostycznych wycieku z brodawki sutkowej u pacjentek poddanych leczeniu operacyjnemu

Background: Spontaneous, one-ductal nipple discharge can be a symptom of intraductal breast hyperplasia. The aim of this study was to assess nipple discharge diagnostic methods and the established diagnostictherapeutic rules in these cases. Material/Methods: 81 women (18-79 years old) were examined at the RCO in Bydgoszcz. Each patient underwent a clinical medical examination, USG, mammography (for patients > 35 years old), galactography, and cytological examination o f nipple discharge. We analyzed the results o f these methods and compared them with histopathological results of operated patients. Results: In 20 of the 81 cases, breast changes were palpable. These could be visualized in 39/81 cases using USG and in 12/73 using mammography. Using galactography, we had diagnostic results in 78/81 cases, the most common symptom being a "filling” defect.. We found 54 papilloma intraductale and 4 carcinoma cases. Conclusions: Galactography is an indispensable diagnostic method in nipple discharge. The main cause of nipple discharge is papilloma