Serum-based biomarkers and magnetic resonance imaging following mild traumatic brain injury in collegiate athletes post return-to-play

Recently there has been an increase in the use of MRI (Magnetic Resonance Imaging), to measure the effects of traumatic brain injury (TBI). Proteins such as BDNF, S100B, UCH-L1, and Tau have been found to have altered levels in blood serum after TBI. However, there is limited knowledge about the relationship between serum-based and MRI-based biomarkers in concussed athletes post return-to-play. This study aimed to bridge this gap by collecting serum samples from 42 participants across two groups. The first group (n = 21) consisted of recently cleared to return-to-play collegiate athletes after experiencing a sports-related concussion. The second group (n = 21) was collegiate athlete controls matched on age, sex, and sport. Structural and functional MRI were used for analysis from a subgroup of 26 participants (13 concussed, 13 control). Blood samples were collected to assess the levels of BDNF, S100B, UCH-L1, and Tau. To the best of our knowledge, this is the first study to analyze protein levels in association with gray matter volume (GMV) and resting state functional connectivity (rsFC) following sports-related concussion. BDNF was the most effective protein at differentiating concussion from control. Significant differential relationships were found between BDNF, S100B, UCH-L1, and Tau with GMV and rsFC, suggesting that serum-based biomarkers may have important clinical implications in concussion diagnosis and treatment

Formation and Disruption of Cosmological Low Mass Objects

We investigate the evolution of cosmological low mass (low virial temperature) objects and the formation of the first luminous objects. First, the `cooling diagram' for low mass objects is shown. We assess the cooling rate taking into account the contribution of H_2, which is not in chemical equilibrium generally, with a simple argument of time scales. The reaction rates and the cooling rate of H_2 are taken from the recent results by Galli & Palla (1998). Using this cooling diagram, we also estimate the formation condition of luminous objects taking into account the supernova (SN) disruption of virialized clouds. We find that the mass of the first luminous object is several times 10^7 solar mass, because smaller objects may be disrupted by the SNe before they become luminous. Metal pollution of low mass (Ly-alpha) clouds also discussed. The resultant metallicity of the clouds is about 1/1000 of the solar metallicity.Comment: 11 pages, 2 figures, To appear in ApJ

Regulated star formation in forming disk galaxies under ultraviolet radiation background

We perform radiation hydrodynamics simulations on the evolution of galactic gas disks irradiated by ultraviolet radiation background. We find gas disks with N_H > 10^21 cm^-2 exposed to ultraviolet radiation at a level of I_21=1 can be self-shielded from photoheating, whereas the disk with N_H < 10^21 cm^-2 cannot. We also find that the unshielded disks keep smooth density distribution without any sign of fragmentation, while the self-shielded disks easily fragment into small pieces by self-gravity, possibly followed by star formation. The suppression of star formation in unshielded disks is different from photoevaporation effect, since the assumed dark halo potential is deep enough to keep the photoheated gas. Presence of such critical threshold column density would be one of the reason for the so-called down-sizing feature of present-day galaxies.Comment: 12pages, 10figures, ApJ accepte

An Application of Kerr Blackhole Fly-Wheel Model to Statistical Properties of QSOs/AGNs

The aim of this work is to demonstrate the properties of the magnetospheric model around Kerr blackholes (BHs), so-called the fly-wheel (rotation driven) model. The fly-wheel engine of the BH-accretion disk system is applied to the statistics of QSOs/AGNs. In the model, the central BH is assumed to be formed at $z \sim 10^2$ and obtains nearly maximum but finite rotation energy ($\sim$ extreme Kerr BH) at the formation stage. The inherently obtained rotation energy of the Kerr BH is released through an magnetohydrodynamic process. This model naturally leads finite lifetime of AGN activity. Nitta et al. (1991) clarified individual evolution of Kerr BH fly-wheel engine which is parametrized by BH mass, initial Kerr parameter, magnetic field near the horizon and a dimension-less small parameter. We impose a statistical model for the initial mass function (IMF) of ensemble of BHs by the Press-Schechter formalism. By the help of additional assumptions, we can discuss the evolution of the luminosity function and the spatial number density of QSOs/AGNs.Comment: 12 pages, 7 figures Fig.7 has been replace

A study of random laser modes in disordered photonic crystals

We studied lasing modes in a disordered photonic crystal. The scaling of the lasing threshold with the system size depends on the strength of disorder. For sufficiently large size, the minimum of the lasing threshold occurs at some finite value of disorder strength. The highest random cavity quality factor was comparable to that of an intentionally introduced single defect. At the minimum, the lasing threshold showed a super-exponential decrease with the size of the system. We explain it through a migration of the lasing mode frequencies toward the photonic bandgap center, where the localization length takes the minimum value. Random lasers with exponentially low thresholds are predicted.Comment: 4 pages, 4 figure

All-angle left-handed negative refraction in Kagome and honeycomb lattice photonic crystals

Possibilities of all-angle left-handed negative refraction in 2D honeycomb and Kagome lattices made of dielectric rods in air are discussed for the refractive indices 3.1 and 3.6. In contrast to triangular lattice photonic crystals made of rods in air, both the honeycomb and Kagome lattices show all-angle left-handed negative refraction in the case of the TM2 band for low normalized frequencies. Certain advantages of the honeycomb and Kagome structures over the triangular lattice are emphasized. This specially concerns the honeycomb lattice with its circle-like equifrequency contours where the effective indices are close to -1 for a wide range of incident angles and frequencies.Comment: 7 pages, 8 figures, pd

The Portuguese observatory on occupational psychosocial factors: contribution for public health

To achieve the goal of sustainable employment, considering the profile of the Portuguese working population (PWP), is needed a range of strategies to ensure long, productive, and sustainable careers allied with a better quality of working life, health, and wellbeing, but also with public health policies grounded on scientifically validated and reliable data. This is possible through a comprehensive working system approach that ensures workers will be mentally and physically able to remain at work by the balance between work demands and individual resources allied with public health policies transfer into the workplaces by organizations’ leadership and policy makers. The Portuguese Observatory on Occupational Factors (Popsy@Work) aims at addressing this global challenge by: i) digitally collecting psychosocial data on the PWP; ii) implementing and strengthening of a psychosocial occupational health surveillance digital system; iii) providing reference values for the PWP concerning Psychosocial Health; iv) Transferring to society knowledge and best practices; v) Raising awareness on the importance of psychosocial management in occupational settings based on science. Popsy@work is a digital platform that collects and aggregates psychosocial data analytically and creates a visualization hub adding value to data on the PWP and giving science back to society in a usable way, empowering workers, strengthening organizations and grounding public policies. Pospy@Work considers the development of strategic intelligence on levels and inequalities of psychosocial health and well-being in occupational settings by robust metrics and reference data. Creating opportunities for national policy dialogue on inequalities, including the psychosocial health of the PWP through collaboration with diverse sectors identifying and mapping subgroups of populations whose unmet needs require specific outreach measures

Lyalpha versus X-ray heating in the high-z IGM

In this paper we examine the effect of X-ray and Lyalpha photons on the intergalactic medium temperature. We calculate the photon production from a population of stars and micro-quasars in a set of cosmological hydrodynamic simulations which self-consistently follow the dark matter dynamics, radiative processes as well as star formation, black hole growth and associated feedback processes. We find that, (i) IGM heating is always dominated by X-rays unless the Lyalpha photon contribution from stars in objects with mass M<10^8 Msun becomes significantly enhanced with respect to the X-ray contribution from BHs in the same halo (which we do not directly model). (ii) Without overproducing the unresolved X-ray background, the gas temperature becomes larger than the CMB temperature, and thus an associated 21 cm signal should be expected in emission, at z<11.5. We discuss how in such a scenario the transition redshift between a 21 cm signal in absorption and in emission could be used to constraint BHs accretion and associated feedback processes.Comment: 7 pages, 3 figures, accepted for publication in MNRA