Analisis Kebutuhan Pembelajaran Berorientasi Kecakapan Hidup (Life Skill) melalui Pengembangan Lembar Kegiatan Siswa (LKS) untuk Pembelajaran IPA di Sekolah Menengah Atas

Pembelajaran di sekolah cenderung sangat teoritis dan tidak terkait dengan lingkungan anak berada. Akibatnya anak didik tidak mampu menerapkan apa yang dipelajari di sekolah guna memecahkan masalah kehidupan yang dihadapi dalam kehidupan sehari -hari. Masalah tersebut dapat diatasi dengan pemberian pendidikan yang terintegerasi pada kecakapan hidup (life skill) yang dapat memberikan bekal pada siswa untuk dapat mandiri dalam mengarungi dunia kerja manakala yang bersangkutan terpaksa tidak dapat melanjutkan pendidikan ke jenjang selanjutnya. Desain penelitian yang akan digunakan adalah jenis penelitian needs assessment. Sedangkan pendekatan yang digunakan dalam penelitian needs assessment ini adalah pendekatan kuantitatif. Pengumpulan data dilakukan dengan teknik kuesioner. Teknik analisis data menggunakan statistik deskriptif, dengan teknik persentase. Hasil penelitian memperlihatkan bahwa secara rerata pemahaman guru-guru sains SMA tentang konsep dan kedudukan pembelajaran berorientasi kecakapan hidup (life skill) melalui pengembangan LKS untuk pembelajaran IPA cukup memahami namun sebarannya tidak merata. Hal ini selain dipengaruhi oleh bidang keahlian yang menjadi tugasnya juga penyikapan terhadap kecakapan hidup (life skill) dalam konteks pembelajaran. Sedangkan pada needs assessment, terdapat kecenderungan bahwa penerapan pembelajaran berorientasi kecakapan hidup (life skill) melalui pengembangan LKS untuk pembelajaran IPA di SMA cukup diperlukan namun tidak signifikan. Hal ini terkait dengan kompetensi menggunakan pembelajaran berorientasi kecakapan hidup (life skill) melalui pengembangan LKS untuk pembelajaran IPA, relevansi dengan bidang studi dan motivasi dalam menggunakan pembelajaran berorientasi kecakapan hidup (life skill) melalui pengembangan LKS untuk pembelajaran IPA di SMA dalam peningkatan kualitas dan kebermaknaan (meaningfull) pembelajaran

Pengaruh Budaya Organisasi, Efikasi Diri Dan Kepuasan Kerja Terhadap Kinerja Mengajar Guru Smk Negeri Kecamatan Denpasar Selatan

Potentials owned by every teacher did not always develop fairly due to the influence of several factors, therefore low impact on the teacher's performance. This study was aimed at discovering of the influence of organization cultural, self efficacy and job satisfaction toward teacher's teaching performance, both separately as well as simultaneously. The study population consisted of 158 teacher all of SMK Negeri Kecamatan Denpasar Selatan, and the 113 a person sampling through proportionate stratified random sampling. This study belonged to a ex-post-facto in the lock of explaining a causal correlational problem descriptivily. The data collected by the support of questionnaire and documentation study. The study results shows; there is a positive and significant influence of organization cultural, self efficacy and job satisfaction toward teacher's teaching performance, with effective contribution separately in a row for 17,6%; 19,8%; 22,4%; and simultaneously by 59,8%. This result means; the influence of job satisfaction on the teacher's teaching performance is the first rank, then the influence of self efficacy on the teacher's teaching performance is the second rank, and the influence of organizational culture on the teacher's teaching performance is the third rank

Inhibition of Striatal Soluble Guanylyl Cyclase-cGMP Signaling Reverses Basal Ganglia Dysfunction and Akinesia in Experimental Parkinsonism

There is clearly a necessity to identify novel non-dopaminergic mechanisms as new therapeutic targets for Parkinson's disease (PD). Among these, the soluble guanylyl cyclase (sGC)-cGMP signaling cascade is emerging as a promising candidate for second messenger-based therapies for the amelioration of PD symptoms. In the present study, we examined the utility of the selective sGC inhibitor 1H-[1], [2], [4] oxadiazolo-[4,3-a]quinoxalin-1-one (ODQ) for reversing basal ganglia dysfunction and akinesia in animal models of PD.The utility of the selective sGC inhibitor ODQ for reversing biochemical, electrophysiological, histochemical, and behavioral correlates of experimental PD was performed in 6-OHDA-lesioned rats and mice chronically treated with MPTP.We found that one systemic administration of ODQ is sufficient to reverse the characteristic elevations in striatal cGMP levels, striatal output neuron activity, and metabolic activity in the subthalamic nucleus observed in 6-OHDA-lesioned rats. The latter outcome was reproduced after intrastriatal infusion of ODQ. Systemic administration of ODQ was also effective in improving deficits in forelimb akinesia induced by 6-OHDA and MPTP.Pharmacological inhibition of the sGC-cGMP signaling pathway is a promising non-dopaminergic treatment strategy for restoring basal ganglia dysfunction and attenuating motor symptoms associated with PD

Properties of MoNxOy thin films as a function of N/O ratio

The main purpose of this work consists on the preparation of single layered molybdenum oxynitride, MoNxOy. The films were deposited on steel substrates by dc reactive magnetron sputtering. The depositions were carried out from a pure Mo target varying the flow rate of reactive gases, which allowed tune the crystallographic structure between insulating oxides and metallic nitrides and consequently electronic, mechanical and optical properties of the material. X-ray diffraction (XRD) results revealed the occurrence of molybdenum nitride for the films with low oxygen fraction: face-centred cubic phases (gama-Mo2N) for low nitrogen flow rate or cubic MoNx and hexagonal phase (delta-MoN) for high nitrogen flow rate. The increase of oxygen content induces an amorphization of the nitride phases and appearance of MoO3 phases. The increase of the oxygen fraction in the films induces also a high decrease in films hardness. Residual stresses revealed to be of compressive type, in the range of very few tenths of GPa to 2 GPa. All these results have been analysed and will be presented as a function of the deposition parameters, the chemical composition and the structure of the films.Fundação para a Ciência e a Tecnologia (FCT) – Pograma Operacional “Ciência, Tecnologia, Inovação” - POCTI/CTM/38086/2001.Comunidade Europeia (CE). Fundo Europeu de Desenvolvimento Regional (FEDER)

Genetic factors associated with patient-specific warfarin dose in ethnic Indonesians

<p>Abstract</p> <p>Background</p> <p><it>CYP2C9 </it>and <it>VKORC1 </it>are two major genetic factors associated with inter-individual variability in warfarin dose. Additionally, genes in the warfarin metabolism pathway have also been associated with dose variance. We analyzed Single Nucleotide Polymorphisms (SNPs) in these genes to identify genetic factors that might confer warfarin sensitivity in Indonesian patients.</p> <p>Methods</p> <p>Direct sequencing method was used to identify SNPs in <it>CYP2C9, VKORC1, CYP4F2, EPHX1, PROC </it>and <it>GGCX </it>genes in warfarin-treated patients. Multiple linear regressions were performed to model the relationship warfarin daily dose requirement with genetic and non-genetic variables measured and used to develop a novel algorithm for warfarin dosing.</p> <p>Results</p> <p>From the 40 SNPs analyzed, <it>CYP2C9 </it>rs17847036 and <it>VKORC1 </it>rs9923231 showed significant association with warfarin sensitivity. In our study population, no significant correlation could be detected between <it>CYP2C9*3, CYP2C9C</it>-65 (rs9332127), <it>CYP4F2 </it>rs2108622, <it>GGCX </it>rs12714145, <it>EPHX1 </it>rs4653436 and <it>PROC </it>rs1799809 with warfarin sensitivity.</p> <p>Conclusions</p> <p><it>VKORC1 </it>rs9923231 AA and <it>CYP2C9 </it>rs17847036 GG genotypes were associated with low dosage requirements of most patients (2.05 ± 0.77 mg/day and 2.09 ± 0.70 mg/day, respectively). <it>CYP2C9 </it>and <it>VKORC1 </it>genetic variants as well as non-genetic factors such as age, body weight and body height account for 15.4% of variance in warfarin dose among our study population. Additional analysis of this combination could allow for personalized warfarin treatment in ethnic Indonesians.</p

Graph MBO method for multiclass segmentation of hyperspectral stand-off detection video

We consider the challenge of detection of chemical plumes in hyperspectral image data. Segmentation of gas is difficult due to the diffusive nature of the cloud. The use of hyperspectral imagery provides non-visual data for this problem, allowing for the utilization of a richer array of sensing information. In this paper, we present a method to track and classify objects in hyperspectral videos. The method involves the application of a new algorithm recently developed for high dimensional data. It is made efficient by the application of spectral methods and the Nyström extension to calculate the eigenvalues/eigenvectors of the graph Laplacian. Results are shown on plume detection in LWIR standoff detection