Radiocarbon Dating of Historical Bricks: Exploring the Unprotected Archaeological Mounds in the Environs of Excavated Site of Nalanda

Nalanda was a renowned Buddhist monastery which is believed to have been active for 800 years from around 4th/5th to 12th centuries AD. We know about the site from the accounts of 7th century Chinese traveler (Xuanzang) and later from 19th century British surveyors (Buchanan, Cunningham and Broadley). There are many studies on this site, recent one among them is a geospatial analysis which has revealed a larger extent (~7.25 sq. km) of the site compared to what is protected at present as World Heritage (WH) inscribed by UNESCO (0.23 sq. km. as core zones and 0.58 sq. km. as buffer zone) and has identified several unprotected archaeological mounds in the vicinity. Since we have a range of period when the site was active, it is possible that the dates of structures in each unexcavated mound are decades or centuries apart. To understand the time sequence in which the site existed one could use absolute dating method. This paper reports result of preliminary dating analysis using the Accelerator Mass Spectrometry (AMS) technique on bricks collected from unprotected mounds in the environs of Nalanda. This paper also reports methods and issues in sample collection, preparation and discusses challenges to overcome in future efforts

Glacio-archaeological evidence of permanent settlements within a glacier end moraine complex during 980-1840 AD: The Miyar Basin, Lahaul Himalaya, India

This study presents glacio-archaeological evidence from the Miyar basin, Lahaul Himalaya, that points towards the former presence of a well settled agricultural society, within a glacier end moraine complex. Three high altitude villages (Tharang, Phundang and Patam, now in ruins) with elaborate irrigation networks thrived within the end moraine complex of Tharang glacier at 3700 m a.s.l. Evidence exists in the form of dilapidated houses which had an organised internal space, chronologically constrained by radiocarbon (14C) dating. These settlements occupied the end moraine complex between 980 and 1840 CE, thereby encompassing the majority of Little Ice Age period (1300–1600 CE), as defined elsewhere. The existence of settlements along with an irrigation system and associate fields at ∼3700-3800 m a.s.l. for almost ∼860 years during the late 10th to early 19th centuries suggests more favourable climatic (warm) conditions that at present. By contrast, present habitation is restricted to areas below ∼3500 m a.s.l. However, the slope controlled irrigation system also suggests moisture stressed conditions during the 980–1840 CE period, similar to present. The available temperature and snowfall proxies for the region support our proposed timing, and suggest favourable climatic conditions for the survival of these settlements

Nations within a nation: variations in epidemiological transition across the states of India, 1990–2016 in the Global Burden of Disease Study

18% of the world's population lives in India, and many states of India have populations similar to those of large countries. Action to effectively improve population health in India requires availability of reliable and comprehensive state-level estimates of disease burden and risk factors over time. Such comprehensive estimates have not been available so far for all major diseases and risk factors. Thus, we aimed to estimate the disease burden and risk factors in every state of India as part of the Global Burden of Disease (GBD) Study 2016

On the paleoseismic evidence of the 1803 earthquake rupture (or lack of it) along the frontal thrust of the Kumaun Himalaya

The foothills of the Himalaya bordered by the Main Frontal Thrust (MFT) continue to be a locus of paleo-seismological studies. One of such recent studies of trench stratigraphy near the central (Indian) Himalayan foothills (Malik et al., (2016) has reported multiple ruptures dated at 467-570, 1294-1587 and 1750-1932 CE. The last offset has been attributed to the Uttarkashi earthquake of 1803 and the penultimate faulting, with lesser confidence to an earthquake in 1505 CE. We tested these claims by logging an adjacent section on a shared scarp, and the new trench site, however, revealed a stratigraphic configuration partially in variance with from what has been reported in the earlier study. Our findings do not support the previous interpretation of the trench stratigraphy that suggested multiple displacements cutting across a varied set of deformed stratigraphic units leading up to the 1803 rupture. The current interpretation posits a single episode of a low-angle displacement at this site occurred between 1266 CE and 1636. Our results suggest a single medieval earthquake, conforming to what was reported from the previously studied neighboring sites to the east and west. The present study while reiterating a great medieval earthquake questions the assumption that the 1803 earthquake ruptured the MFT. Although a decollement earthquake, the 1803 rupture may have been arrested midway on the basal flat, and fell short of reaching the MFT, somewhat comparable to a suite of blind thrust earthquakes like the 1905 Kangra and the 1833 Nepal earthquakes

Ag ion implanted TiO2 photoanodes for fabrication of highly efficient and economical plasmonic dye sensitized solar cells

Materials with tunable optical and photoelectric properties are prerequisite for the development of highly stable, economical and efficient dye sensitized solar cells (DSSCs). In this direction, improved plasmonic DSSCs with comparatively higher light harvesting ability and reduced recombination of photo-generated charge carriers have been fabricated using low energy (120 KeV) Ag ion implanted TiO2 photoanodes at variable fluence. Herein, the origin of improved photovoltaic performance of Ag implanted DSSCs against conventional DSSC has been explained using UV-visible, photoluminescence and kelvin probe measurements. Further, the efficient interfacial charge transportation within Ag implanted DSSCs has been demonstrated through EIS measurements

Prognostic Relevance of PDL1 and CA19-9 Expression in Gallbladder Cancer vs. Inflammatory Lesions

Chronic inflammation in the gallbladder leading to persistent epithelium damage promotes invasive cancer. The study aimed to assess the prognostic value of PDL1 and CA19-9 markers in cancer/inflammatory lesions of the gallbladder. A total of 29 cases (19 cancer and 10 inflammatory) were included. The PDL1 protein concentration level and mRNA expression were assessed in the tissues’ lysates by ELISA and real-time PCR, respectively. PDL1 and CA19-9 concentration levels were compared and statistically related with clinico-pathological variables. The PDL1 protein level and its relative mRNA expression were correlated. Kaplan–Meir survival and Cox regression analyses were conducted for predicting prognosis. This study investigated the PDL1 and CA19-9 marker expression in both cancer and inflammatory cases of the gallbladder (p = 0.48 and p = 0.17 respectively). PDL1 protein expression was significantly associated with the hormonal profile of the cases (p = 0.04) at an optimum cut-off value of 13 pg/mL, while the CA19-9 marker expression was correlated with the status of liver metastasis (p = 0.0043) and size of the tumor (p = 0.004). A low PDL1 concentration was found when compared to the CA19-9 level among cancer cases (p = 0.12) and proportional in the inflammatory lesions (p = 0.63). A significant positive correlation was found between the PDL1 protein and its relative mRNA expressions in the inflammatory lesions (p = 0.029) when compared to cancer cases (p = 0.069). Our results showed that a protein-based assay for PDL1 expression would be more sensitive compared to RNA based assays for GBC risk stratifications. Overall survival was predicted with CA19-9 and PDL1 levels (p = 0.0074, p = 0.23, respectively). PDL1 and CA19-9 may act as a probable predictor of a poor prognosis in gallbladder cancer (GBC) cases

Prognostic Relevance of PDL1 and CA19-9 Expression in Gallbladder Cancer vs. Inflammatory Lesions

Chronic inflammation in the gallbladder leading to persistent epithelium damage promotes invasive cancer. The study aimed to assess the prognostic value of PDL1 and CA19-9 markers in cancer/inflammatory lesions of the gallbladder. A total of 29 cases (19 cancer and 10 inflammatory) were included. The PDL1 protein concentration level and mRNA expression were assessed in the tissues’ lysates by ELISA and real-time PCR, respectively. PDL1 and CA19-9 concentration levels were compared and statistically related with clinico-pathological variables. The PDL1 protein level and its relative mRNA expression were correlated. Kaplan–Meir survival and Cox regression analyses were conducted for predicting prognosis. This study investigated the PDL1 and CA19-9 marker expression in both cancer and inflammatory cases of the gallbladder (p = 0.48 and p = 0.17 respectively). PDL1 protein expression was significantly associated with the hormonal profile of the cases (p = 0.04) at an optimum cut-off value of 13 pg/mL, while the CA19-9 marker expression was correlated with the status of liver metastasis (p = 0.0043) and size of the tumor (p = 0.004). A low PDL1 concentration was found when compared to the CA19-9 level among cancer cases (p = 0.12) and proportional in the inflammatory lesions (p = 0.63). A significant positive correlation was found between the PDL1 protein and its relative mRNA expressions in the inflammatory lesions (p = 0.029) when compared to cancer cases (p = 0.069). Our results showed that a protein-based assay for PDL1 expression would be more sensitive compared to RNA based assays for GBC risk stratifications. Overall survival was predicted with CA19-9 and PDL1 levels (p = 0.0074, p = 0.23, respectively). PDL1 and CA19-9 may act as a probable predictor of a poor prognosis in gallbladder cancer (GBC) cases

Neolithic cultural sites and extreme climate related channel avulsion: Evidence from the Vaigai River Basin, southern India

We document evidence for the role of fluvial dynamics-stream channel avulsion and flooding, tectonics and climatic conditions on the occurrence, shifting and burial of ancient cultural sites in the Vaigai River Basin in southern India. Systematic regional mapping, geophysical investigations and archaeological excavations in the flood plains of the Vaigai River led to the unearthing of an ancient culture that thrived at least since 752 BCE (2435 +/- 34 BP). Evidence for early human activities include sites of ancient and now buried industries that were manufacturing steel, glass bead, dye, gold jewelry and earthenware, in addition to dwelling-habitation, sites of religious sacrificial ceremonies, and places of worship, and burial. These information together with the occurrences of microlithic age stone tools in the vicinity led to the proposition of continued habitation of the Vaigai River Basin until today. Radiometric dating shows oldest age of 2435 +/- 34 BP (752 BCE) obtained at 2.5 m depth in a pit excavated at Keezhadi, a location situated far from the present day channel course whereas the youngest age of 689 +/- 24 BP is obtained at Agaram, a location situated nearest to the present day channel course. The bone fragments were dated as 1115 +/- 39 BP (778 CE - 1016 CE) and 1229 +/- 30 BP (689 CE - 883 CE). The organic carbon/peat layers recovered between flood deposits at the upper reaches of the Vaigai River are dated as 830 +/- 30 BP and 1250 +/- 30 BP. The natural levee deposits show evidences of habitation-related disturbances in the internal sedimentary structure, texture and packing. In addition to occurrences of hearth etc., re-currences of overbank-channel deposits over natural levee-habitation surfaces indicate habitation-colonization over relatively highgrounds along river bank, followed by marooning/burial under overbank-channel deposit and abandon -ment of habitation site and/or shifting of habitat. The same sequence of events occurred again, showing two habitation surfaces that are buried under surface currently. Together with facies characteristics and other artifact occurrences, the ages obtained in our study indicate shifting of the Vaigai River from prior to 2435 BP and colonization of ancient population, which might have been affected by a catastrophic flood and stream avulsion at about 1250-830 BP. These resulted in the ancient habitation getting marooned, industries and other structural infrastructure destroyed, and were transported and deposited as interbeds in flood deposits. Following a reduction in the stream energy, the point bar-natural levee environmental setting paved way for the deposition of organic carbon layer at Agaram at about 690 BP. This was followed by lateral shifting of the channel from Agaram towards the present-day course