Decision support tools of sustainability assessment for urban stormwater management - A review of their roles in governance and management

Urban areas face growing sustainable challenges arising from stormwater issues, necessitating the evolution of stormwater management concept and practice. This transformation not only entails the adoption of a multifunctional, holistic, and sustainable approach but also involves the integration of water quality and quantity considerations with governance and management aspects. A means to do so is via decision support tools. However, whilst existing studies using the tools by employing sustainability assessment principles or as indicators to plan blue-green infrastructures and strategies, uncertainties remain regarding how decision support tools encompass governance and management dimensions. The aim of this review study is to provide muchneeded clarity on this aspect, in doing so, a systematic review of decision support tools used in sustainability assessment within the stormwater management context is conducted, focusing on their abilities to include governance and management. Findings encompass governance aspects, such as actors, discourses, rules, and resources considered, and explore how these relate to long-term management. The results reveal the recognized potential of decision support tools in facilitating governance and management for sustainable stormwater management, however, future research and efforts need to be allocated in: (i) Exploring practical challenges in integrating all sustainability assessment pillars with consistent criteria into decision support tools, to determine the optimal use of all criteria in fostering open and informed stormwater governance and management. (ii) Understanding how to engage diverse stormwater actors with future decision support tools, to secure ownership and relevance. (iii) Using retrospective (ex-post) sustainability assessments to provide more tangible knowledge and to support long-term management

Pathologic fracture does not influence prognosis in stage IIB osteosarcoma: a case–control study

OBJECTIVE: This study tested the implication of pathologic fractures on the prognosis in stage IIb osteosarcoma. METHODS: A single center retrospective evaluation of clinical management and oncologic outcome was conducted with 15 pathological fracture patients (M:F = 10:5; age: mean 23.2, range 12–42) and 50 non-fracture patients between April 2002 and December 2010. These stage IIB osteosarcoma patients were matched for age, tumor site (femur, tibia, and humerus), and osteosarcoma subtype (i.e., control patients with osteosarcoma in the same sites as the fracture patients). All osteosarcoma patients with pathological fractures underwent brace or cast immobilization, adjuvant chemotherapy, and limb salvage surgery or amputation. Musculoskeletal Tumor Society (MSTS) functional scores were assessed. The mean follow-up time was 34.7 months (range, 8–47 months). RESULTS: Following limb salvage surgery, no statistical differences were observed in major complications (fracture = 20.0%, control = 12.0%, P = 0.43) or local recurrence complications (fracture = 26.7%, control = 14.0%, P = 0.25). Overall 3-year survival rates of the fracture and control groups (66.7% and 75.3%, respectively) were not statistically different (P = 0.5190). Three-year disease-free survival rates of the fracture and control groups were 53.3% and 66.5%, respectively (P = 0.25). CONCLUSIONS: Pathologic fracture was not a prognostic indicator of recurrence or overall survival in localized osteosarcoma patients. Limb salvage can be achieved by and maintaining adequate surgical margins and applying adjuvant chemotherapy

Stable smectic phase in suspensions of polydisperse colloidal platelets with identical thickness

6 pages, 6 figures.-- PACS nrs.: 61.30.Eb, 64.70.M−, 81.16.Dn, 82.70.Dd.-- ArXiv pre-print available at: http://arxiv.org/abs/0909.2625We report the nematic and smectic ordering in an aqueous suspension of monolayer α-Zirconium phosphate platelets possessing a high polydispersity in diameter but uniform thickness. We observe an isotropic-nematic transition as the platelet volume fraction increases, followed by the formation of a smectic, an elusive phase that has been rarely seen in discotic liquid crystals. The smectic phase is characterized by x-ray diffraction high-resolution transmission electron microscopy, and optical microscopy. The phase equilibria in this highly polydisperse suspension are rationalized in terms of a theoretical approach based on density-functional theory.Acknowledgment is made to the donors of ACS Petroleum Research Fund (Grant No. 45303-G7) and to the Dow Chemical Co. This work has been partly financed by start-up funds from Texas Engineering Experimental Station and Texas A&M University, by Grants No. NANOFLUID, No. MOSAICO, and No. S-0505/ESP-0299 from Comunidad Autónoma de Madrid (Spain), and Grants No. FIS2005-05243-C02-01, No. FIS2007-65869-C03-01, No. FIS2008-05865-C02-02, and No. FIS2007-65869-C03-C01 from Ministerio de Educación y Ciencia (Spain).Publicad

Comparison of short-term efficacy between unilateral biportal endoscopic lumbar interbody fusion and minimally invasive surgery transforaminal lumbar interbody fusion for lumbar spinal stenosis

Objective To compare the short-term efficacy of unilateral biportal endoscopic lumbar interbody fusion (ULIF) and minimally invasive surgery transforaminal lumbar interbody fusion (MIS-TLIF) in the treatment of lumbar spinal stenosis. Methods Clinical data of 87 patients with lumbar spinal stenosis from April 2020 to June 2022 were retrospectively analyzed. Among them, 43 cases were treated with ULIF (ULIF group) and 44 cases were treated with MIS-TLIF (MIS-TLIF group). The surgical time, intraoperative blood loss, postoperative ambulation time, drainage tube removal time, hospital stay, postoperative complications, visual analog scale (VAS) scores for back and leg pain, as well as Oswestry disability index (ODI) were compared between the two groups. Results Compared with the MIS-TLIF group, the ULIF group had a longer surgical time, with statistically significant difference (P＜0.05). There was no significant difference in intraoperative blood loss, postoperative ambulation time, drainage tube removal time and hospital stay between the two groups (P＞0.05). Two cases in the ULIF group and one case in the MIS-TLIF group experienced cerebrospinal fluid leakage postoperatively, but there were no other complications in either group. There was no statistically significant difference in the incidence of complications between the two groups (P＞0.05). Both groups were followed up for 12 months. The fusion rate in the ULIF group was significantly higher than that in the MIS-TLIF group at 6 months (81.4% vs 59.1%, χ2=5.163, P＜0.05) and 12 months (90.7% vs 68.2%, χ2=6.179, P＜0.05) after surgery. Conclusion For patients with lumbar spinal stenosis, ULIF can achieve similar efficacy to MIS-TLIF, while providing higher decompression efficiency, greater surgical instrument flexibility, and more thorough intervertebral space treatment. However, ULIF has a longer surgical time

4-Hydr­oxy-3-[(2E)-3-(3,4,5-trimethoxy­phen­yl)prop-2-eno­yl]-2H-chromen-2-one

A new chalcone of the coumarin, C21H18O7, containing an annulated α-pyrone ring, was obtained by condensation of the borate complex of ac­yl(hydr­oxy)coumarin with trimethoxy­benzaldehyde. The structure exhibits intra­molecular hydrogen bonding between the hydroxyl oxygen and the ketonic oxygen in the coumarin group. The bicyclic coumarin fragment and the benzene ring form a dihedral angle of 17.1 (4)°. The crystal packing involves dimers inter­connected by C—H⋯O hydrogen bonding

First-line treatment with chemotherapy plus cetuximab in Chinese patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck: Efficacy and safety results of the randomised, phase III CHANGE-2 trial.

Abstract Background The EXTREME regimen (chemotherapy [CT; cisplatin/carboplatin and 5-fluorouracil]) plus cetuximab is a standard-of-care first-line (1L) treatment for patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN), as supported by international guidelines. The phase III CHANGE-2 trial assessed the efficacy and safety of a modified CT regimen (with a reduced dose of both components) and cetuximab versus CT for the 1L treatment of Chinese patients with R/M SCCHN. Methods Patients were randomised to receive up to six cycles of CT plus cetuximab followed by cetuximab maintenance until progressive disease or CT alone. The primary end-point was the progression-free survival (PFS) time assessed by the independent review committee (IRC). Results Overall, 243 patients were randomised (164 to CT plus cetuximab; 79 to CT). The hazard ratios for PFS by IRC and overall survival (OS) were 0.57 (95% CI: 0.40–0.80; median: 5.5 versus 4.2 months) and 0.69 (95% CI: 0.50–0.93; median: 11.1 versus 8.9 months), respectively, in favour of CT plus cetuximab. The objective response rates (ORR) by IRC were 50.0% and 26.6% with CT plus cetuximab and CT treatment, respectively. Treatment-emergent adverse events of maximum grade 3 or 4 occurred in 61.3% (CT plus cetuximab) and 48.7% (CT) of patients. Conclusions CHANGE-2 showed an improved median PFS, median OS and ORR with the addition of cetuximab to a modified platinum/5-fluorouracil regimen, with no new or unexpected safety findings, thereby confirming CT plus cetuximab as an effective and safe 1L treatment for Chinese patients with R/M SCCHN. Clinical trial registration number NCT02383966

A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population.

Prostate cancer predisposition has been extensively investigated in European populations, but there have been few studies of other ethnic groups. To investigate prostate cancer susceptibility in the under-investigated Chinese population, we performed single-nucleotide polymorphism (SNP) array analysis on a cohort of Chinese cases and controls and then meta-analysis with data from the existing Chinese prostate cancer genome-wide association study (GWAS). Genotyping 211,155 SNPs in 495 cases and 640 controls of Chinese ancestry identified several new suggestive Chinese prostate cancer predisposition loci. However, none of them reached genome-wide significance level either by meta-analysis or replication study. The meta-analysis with the Chinese GWAS data revealed that four 8q24 loci are the main contributors to Chinese prostate cancer risk and the risk alleles from three of them exist at much higher frequencies in Chinese than European populations. We also found that several predisposition loci reported in Western populations have different effect on Chinese men. Therefore, this first extensive single-nucleotide polymorphism study of Chinese prostate cancer in comparison with European population indicates that four loci on 8q24 contribute to a great risk of prostate cancer in a considerable large proportion of Chinese men. Based on those four loci, the top 10% of the population have six- or two-fold prostate cancer risk compared with men of the bottom 10% or median risk respectively, which may facilitate the design of prostate cancer genetic risk screening and prevention in Chinese men. These findings also provide additional insights into the etiology and pathogenesis of prostate cancer.This work was conducted on behalf of the CHIPGECS and The PRACTICAL consortia (see Supplementary Consortia). We acknowledge the contribution of doctors, nurses and postgraduate research students at the CHIPGENCS sample collecting centers. We thank Orchid and Rosetrees for funding support. This work was also supported by National Natural Science foundation of China for funding support to H Zhang (Grant No: 30671793 and 81072377), N Feng (Grant No: 81272831), X Zhang (Grant No: 30572139, 30872924 and 81072095), S Zhao (Grant No: 81072092 and 81328017), Y Yu (Grant No: 81172448) and Program for New Century Excellent Talents in University from Department of Education of China (NCET-08-0223) and the National High Technology Research and Development Program of China (863 Program 2012AA021101) to X Zhang.This is the final version of the article. It first appeared from Impact Journals via http://dx.doi.org/10.18632/oncotarget.725

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Decision support tools of sustainability assessment for urban stormwater management – A review of their roles in governance and management

Urban areas face growing sustainable challenges arising from stormwater issues, necessitating the evolution of stormwater management concept and practice. This transformation not only entails the adoption of a multifunctional, holistic, and sustainable approach but also involves the integration of water quality and quantity considerations with governance and management aspects. A means to do so is via decision support tools. However, whilst existing studies using the tools by employing sustainability assessment principles or as indicators to plan blue-green infrastructures and strategies, uncertainties remain regarding how decision support tools encompass governance and management dimensions. The aim of this review study is to provide much-needed clarity on this aspect, in doing so, a systematic review of decision support tools used in sustainability assessment within the stormwater management context is conducted, focusing on their abilities to include governance and management. Findings encompass governance aspects, such as actors, discourses, rules, and resources considered, and explore how these relate to long-term management. The results reveal the recognized potential of decision support tools in facilitating governance and management for sustainable stormwater management, however, future research and efforts need to be allocated in: (i) Exploring practical challenges in integrating all sustainability assessment pillars with consistent criteria into decision support tools, to determine the optimal use of all criteria in fostering open and informed stormwater governance and management. (ii) Understanding how to engage diverse stormwater actors with future decision support tools, to secure ownership and relevance. (iii) Using retrospective (ex-post) sustainability assessments to provide more tangible knowledge and to support long-term management.Validerad;2024;Nivå 2;2024-04-09 (joosat);Full text license: CC BY</p