The development of spiritual and moral values in homeless adolescents in social and educational rehabilitation

The article deals with the problem of homeless adolescents. Reasons for the need of spiritual and moral values in homeless adolescents are justified. We also have disclosed the features of the socio-pedagogical rehabilitation of homeless adolescents.В статье рассмотрена проблема беспризорности подростков. Обосновываются причины необходимости развития духовно-нравственных ценностей у беспризорных подростков. Раскрыты особенности социально-педагогической реабилитации беспризорных подростков

Econometric models for forecasting of macroeconomic indices

The urgency of the research topic was stipulated by the necessity to carry out an effective controlled process by the economic system which can hardly be imagined without indices forecasting characteristic of this system. An econometric model is a safe tool of forecasting which makes it possible to take into consideration the trend of indices development in the past and their cause and effect interrelations. The aim of the article is to build econometric models for macroeconomic indices forecasting, reflecting Russia’s economy stabilization processes. In the process of research econometric modeling methods were used which allow to build, estimate and control the quality of various econometric models. In the given research the following models were built and analyzed: autoregressive integrated moving average model, vector auto-regression model, simultaneous equations system; the comparison of forecast possibilities and forecast accuracy of models built; forecast values of considered macroeconomic indices for the next periods were received. As to the results of study some preference can be given to forecasting on the basis of autoregressive models. The materials of the article can be quite useful for researchers, dealing with problems of modeling and economic processes forecasting, both in their scientific and practical activity. © 2016 Sukhanova, Shirnaeva and Mokronosov

Overview of potential drugs for the treatment of new coronavirus Infection (COVID-19)

The new coronavirus infection (SARS-CoV-2), better known as COVID-19, quickly evolved into a worldwide pandemic with a significant public health burden. Currently, there are no approved drugs or preventive therapeutic strategies to combat infection. Decisions about prescribing many medications are made based on the results obtained in in vitro studies, or expert opinions. Most of the drugs currently used to treat COVID-19 are approved antivirals or antibodies against other diseases. However, there are hundreds of clinical studies underway around the world to discover effective treatments for COVID-19. This article summarizes the results of clinical studies of potential therapeutic drugs used as COVID-19 therapy. Based on this review, it can be concluded that there is still no high-quality evidence to support any of the drugs described below. Until the unambiguous results of randomized controlled trials are available, the use of any of the following drugs is not clinically proven as an effective treatment for COVID-19

Trypsin. Properties and Use in the Production of Biological Medicinal Products

The production of biological medicinal products used for prophylactic, diagnostic and therapeutic purposes includes the use of inherently  variable biological processes and materials. In order to ensure the  quality of the finished biological product it is necessary to determine  the source, nature and fitness for use of the starting materials, including reagents, culture media, buffer solutions, sera,  and enzymes. The article summarises literature data on the  structure, properties and mode of action of the animal-derived  reagent trypsin — proteolytic enzyme widely used in the production  of biological medicinal products. The article dwells upon the sources  of trypsin, methods of its production, requirements for trypsin  products of different purity grades intended for human and  veterinary use as well as for use as reagents in the production of  vaccines, advanced therapy medicinal products and genetically engineered products. The article describes the role that  trypsin plays in the human and animal intestinal digestive enzyme  systems, in dissociation of cells in cultures in the process of cell  passaging, in the mechanism of proteolitic activation and inactivation of a wide range of viruses, and in the examination of proteins  primary structure

BLENDS OF POLY-3-HYDROXYBUTYRATE AND POLY-ε-CAPROLACTONE:MORPHOLOGY, PROPERTIES AND BIOCOMPATIBILITY

The use of biocompatible and biodegradable polymers is essential for modern biomedicine. One of the approaches to improving the mechanical properties of pure polymers is to obtain mixtures based on them.This work was carried within the state assignment of the Ministry of Science and Higher Education of the Russian Federation, project No. FEFE-2020-0015

Analysis of approaches to sterility testing of COVID-19 prevention vaccines

Preventive vaccination against SARS-CoV-2 infection is currently receiving close attention in the Russian Federation. Improving public confidence in immunisation with new vaccines largely depends on a guarantee of the absence of side effects caused by contamination. A high risk of contamination is inherent to biological products, including coronavirus prevention vaccines, due to their properties and the nature of raw materials used. This risk adds to the need for using effective contaminant detection approaches.The aim of the study was to evaluate the possibility to improve sterility testing of preventive vaccines against SARS-CoV-2 infection.This article presents an analysis of the procedures proposed by pharmaceutical developers for sterility testing of ten Russian vaccines approved in the country for COVID-19 prevention. The authors considered specific characteristics of these vaccines, including their physical and chemical properties, the presence of antimicrobial components, and other critical factors affecting the correctness of the experimental setup. The results suggest that it is possible to improve sterility testing. According to the authors, the main directions for its improvement are the proposal to develop an alternative procedure based on compendial method 2 (OFS.1.2.4.0003.15, Ph. Rus. XIV), as well as the use of a universal culture medium. If used for refining the established procedures and developing new ones, the authors’ recommendations will improve the reliability and applicability of sterility testing during both manufacturing and pre-approval regulatory assessment of updated coronavirus vaccines for subsequent release to the market. The proposed approaches can be applied to testing other medicinal products for sterility

Student readiness formation for activities oriented to health saving

The relevance of the studied problem is caused by the need of formation and development among students of educational organizations of the personal qualities directed to updating of their potential concerning preservation and promotion of health, organization of own style of a healthy lifestyle, i.e. formation of readiness for healthoriented activity - HOA. The purpose of the article consists in the development of conceptual aspects of readiness formation of students for HOA. The leading methodological approach to the research of this problem is a personal and activity approaches, allowing us to disclose the features of organization of an educational process directed to readiness formation of students for HOA. Conceptual aspects of students’ readiness formation for HOA conclude in the fact that health is considered as a target resource of a person which can be operated; the basis of this resource is the health saving potential of the person, its components and phases of development are presented; the model of student readiness for HOA is developed. Materials of the article can be useful to pedagogical workers regarding the organization of activities for preservation and promotion of student health in educational organizations, by means of change of intrinsic and substantial components of this activity. © 2016 Tretyakova et al

Eritrocytic Parameters of the Blood of Calves with Different Birth Weights

In the conditions of a dairy farm with the help of the standard clinical, instrumental and laboratory methods the research on particularities of Eritrocytic parameters of the blood of calves (n=299) with different birth weights was carried out. It is shown that Holstein calves with normal intrauterine growth, born with body weight from 36.5 to 29 kg, have no reliable differences in red blood cell count. With a 1 kg reduction in body weight, there is a trend towards hyperchromia, but an increase in weight deficiency promotes of hypovolemia, hypochromia, and polycythaemia. In newborns with a body weight of 27.9–26.9 kg, polycythaemia is derived from hypovolemia, but, with a more pronounced weight deficiency, the role of erythrogenesis disorder in the pathogenesis of the syndrome increases. Hypochromia is a consequence of hematopoietic organs dysfunction and transmembrane loss of hemoglobin. Herein membrane destruction is caused by the increase in the content of toxical metabolites in the blood (sorptivity of red blood cells by 10–12 percent), and by a higher level of adrenaline (modification coefficient of membranes by adrenaline by 20–30 %). This indicates that the response of the fetus to the factors that inhibit its development is similar to a metabolic response against stress. At strong underweight body (b.w. less than 25 kg) exhausting of adaptive capability is observed with the increase in the blood level of toxical metabolites (sorptivity of red blood cells by 15 %), level of membrane destruction (level of ectoglobular hemoglobin in 2,8 times), and heterogeneity of red blood cells. Thus, in newborns with a body weight of less than 29 kg, the significant disturbances in the structure and functions of red blood cells were revealed, which gave grounds for stating that they had antenatal hypotrophy. Herewith, the severity of hematological changes depends on the degree of weight deficiency. Initially, it is hypovolemia and the resulting polycythemia, but, erythropoiesis disorders, and destruction of their membranes with increased polycythemia, and the development of hypochromia occur with the increasing severity of hypotrophy

Influence of the participatory budgeting on the infrastructural development of the territories in the Russian federation

The relevance of the investigated problem is caused by the need for the advancing of participatory budgeting practice in the Russian Federation. Due to insufficient development of theoretical, scientific, and methodological aspects of the participatory budgeting, very few territories in the Russian Federation use this tool effectively. The most important issue to be addressed is increasing the effectiveness of involving of local communities in the process of the rational allocation of budgetary funds. The objective of this paper is to study how participatory budgeting influences the potential of infrastructural development of territories in the Russian Federation. The leading methods of investigation of the problem include analyzing the common practices in certain regions and specifying the different categories of participatory budgeting. Using these methods, the authors consider the participatory budgeting as a process of allocating the budget funds to address the primary local problems, which leads to improving territorial infrastructure development. The results of the given research include updated conceptual basis of participatory budgeting; indicators reflecting the influence of the participatory budgeting on infrastructural development and criteria for its implementation in the municipalities; organizational chart clarifying the methodological aspects of different types of the participatory budgeting; and classification of territorial development mechanisms based on the participatory budgeting models of financing municipal projects. The practical significance of the given research is focused on the development of the practice of the relevant projects financing through the participatory budgeting in the Russian regions by systematizing their conceptual frameworks. Results of the study can be used by regional and municipal authorities to improve the relevant legislation, and by representatives of local communities to increase their participation in the budgeting process. © 2016 Tsurkan et al