An investigation into the numerical prediction of boundary layer transition using the K.Y. Chien turbulence model

Assessments were made of the simulation capabilities of transition models developed at the University of Minnesota, as applied to the Launder-Sharma and Lam-Bremhorst two-equation turbulence models, and at The University of Texas at Austin, as applied to the K. Y. Chien two-equation turbulence model. A major shortcoming in the use of the basic K. Y. Chien turbulence model for low-Reynolds number flows was identified. The problem with the Chien model involved premature start of natural transition and a damped response as the simulation moved to fully turbulent flow at the end of transition. This is in contrast to the other two-equation turbulence models at comparable freestream turbulence conditions. The damping of the transition response of the Chien turbulence model leads to an inaccurate estimate of the start and end of transition for freestream turbulence levels greater than 1.0 percent and to difficulty in calculating proper model constants for the transition model

Endpoint temperature, cooking method, and marbling degree have different effects on Warner-Bratzler shear force of beef strip loin, bottom round, and brisket muscles

Our objective was to determine the effects of endpoint temperature, cooking method, and marbling on Warner-Bratzler shear force (WBSF; an objective method for determining tenderness) of three beef muscles. Eighteen subprimals of a muscle containing low content of connective tissue, longissimus lumborum (strip loin), and two muscles containing a high content of connective tissue, biceps femoris (bottom round) and deep pectoralis (brisket), were selected from USDA Select and Choice (Certified Angus Beef) carcasses. After 14 days of aging, subprimals were frozen, fabricated into steaks, and stored frozen until cooking. Steaks were assigned to one of two cooking methods, the Magikitch’n® electric belt grill (a rapid conduction method) or a water bath (a slower, convection method); and one of nine endpoint cooking temperatures, 104, 113, 122, 131, 140, 149, 158, 167, or 176°F. According to WBSF results, optimum tenderness for the strip loin occurred around 131°F. Higher marbling protected tenderness at higher endpoint temperatures. Tenderness increased in bottom round and brisket muscles as endpoint temperature increased from 104 to 140°F, then tenderness decreased as endpoint temperature rose from 149 to 176°F. Endpoint temperature was the only significant factor affecting bottom round tenderness. Steaks cooked in the water bath had higher WBSF and, therefore, were less tender than those cooked on the belt grill. This was true for both the strip loin and brisket. The effect of increasing endpoint temperature on WBSF of the strip loin was different than for the bottom round and brisket

Limits on Quaoar's Atmosphere

Here we present high cadence photometry taken by the Acquisition Camera on Gemini South, of a close passage by the ~540 km radius Kuiper belt object, (50000) Quaoar, of a r' = 20.2 background star. Observations before and after the event show that the apparent impact parameter of the event was 0."019 ± 0."004, corresponding to a close approach of 580 ± 120 km to the center of Quaoar. No signatures of occultation by either Quaoar's limb or its potential atmosphere are detectable in the relative photometry of Quaoar and the target star, which were unresolved during closest approach. From this photometry we are able to put constraints on any potential atmosphere Quaoar might have. Using a Markov chain Monte Carlo and likelihood approach, we place pressure upper limits on sublimation supported, isothermal atmospheres of pure N_2, CO, and CH_4. For N_2 and CO, the upper limit surface pressures are 1 and 0.7 μbar, respectively. The surface temperature required for such low sublimation pressures is ~33 K, much lower than Quaoar's mean temperature of ~44 K measured by others. We conclude that Quaoar cannot have an isothermal N_2 or CO atmosphere. We cannot eliminate the possibility of a CH_4 atmosphere, but place upper surface pressure and mean temperature limits of ~138 nbar and ~44 K, respectively

In-Situ Infrared Transmission Study of Rb- and K-Doped Fullerenes

We have measured the four IR active $C_{60}$ molecular vibrations in $M_{x}C_{60}$ $(M = K, Rb)$ as a function of doping $x$. We observe discontinuous changes in the vibrational spectra showing four distinct phases (presumably $x = 0, 3, 4$, and 6). The $1427cm^{-1}$ and $576cm^{-1}$ modes show the largest changes shifting downward in frequency in four steps as the doping increases. Several new very weak modes are visible in the $x=6$ phase and are possibly Raman modes becoming weakly optically active. We present quantitative fits of the data and calculate the electron-phonon coupling of the $1427cm^{-1}$ IR mode.Comment: 3 pages, Figure 1 included, 3 more figures available by request. REVTEX v3.0 IRC60DO

Fire Treatment Effects on Vegetation Structure, Fuels, and Potential Fire Severity in Western US Forests

Forest structure and species composition in many western U. S. coniferous forests have been altered through. re exclusion, past and ongoing harvesting practices, and livestock grazing over the 20th century. The effects of these activities have been most pronounced in seasonally dry, low and mid-elevation coniferous forests that once experienced frequent, low to moderate intensity,. re regimes. In this paper, we report the effects of Fire and Fire Surrogate (FFS) forest stand treatments on fuel load profiles, potential fire behavior, and fire severity under three weather scenarios from six western U. S. FFS sites. This replicated, multisite experiment provides a framework for drawing broad generalizations about the effectiveness of prescribed. re and mechanical treatments on surface fuel loads, forest structure, and potential. re severity. Mechanical treatments without. re resulted in combined 1-, 10-, and 100-hour surface fuel loads that were significantly greater than controls at three of five FFS sites. Canopy cover was significantly lower than controls at three of five FFS sites with mechanical-only treatments and at all five FFS sites with the mechanical plus burning treatment;. re-only treatments reduced canopy cover at only one site. For the combined treatment of mechanical plus. re, all five FFS sites with this treatment had a substantially lower likelihood of passive crown. re as indicated by the very high torching indices. FFS sites that experienced significant increases in 1-, 10-, and 100-hour combined surface fuel loads utilized harvest systems that left all activity fuels within experimental units. When mechanical treatments were followed by prescribed burning or pile burning, they were the most effective treatment for reducing crown fire potential and predicted tree mortality because of low surface fuel loads and increased vertical and horizontal canopy separation. Results indicate that mechanical plus fire, fire-only, and mechanical-only treatments using whole-tree harvest systems were all effective at reducing potential. re severity under severe. re weather conditions. Retaining the largest trees within stands also increased. re resistance

WISEP J180026.60+013453.1: A Nearby Late L Dwarf Near the Galactic Plane

We report a nearby L7.5 dwarf discovered using the Preliminary Data Release of the Wide-field Infrared Survey Explorer (WISE) and the Two Micron All-Sky Survey (2MASS). WISEP J180026.60+013453.1 has a motion of 0.42 arcsec/yr and an estimated distance of 8.8 \pm 1.0 pc. With this distance, it currently ranks as the sixth closest known L dwarf, although a trigonometric parallax is needed to confirm this distance. It was previously overlooked because it lies near the Galactic Plane (b=12). As a relatively bright and nearby late L dwarf with normal near-infrared colors, W1800+0134 will serve as a benchmark for studies of cloud-related phenomena in cool substellar atmospheres.Comment: 12 pages, 2 figure, accepted to the Astronomical Journal (AJ

CYP1A1 and CYP1B1-mediated biotransformation of the antitrypanosomal methamidoxime prodrug DB844 forms novel metabolites through intramolecular rearrangement

DB844 (CPD-594-12), N-methoxy-6-{5-[4-(N-methoxyamidino)phenyl]-furan-2-yl}- nicotinamidine, is an oral prodrug that has shown promising efficacy in both mouse and monkey models of second stage human African trypanosomiasis. However, gastrointestinal (GI) toxicity was observed with high doses in a vervet monkey safety study. In the current study, we compared the metabolism of DB844 by hepatic and extrahepatic cytochrome P450s to determine if differences in metabolite formation underlie the observed GI toxicity. DB844 undergoes sequential O-demethylation and N-dehydroxylation in the liver to form the active compound DB820 (CPD-593-12). However, extrahepatic CYP1A1 and CYP1B1 produced two new metabolites, MX and MY. Accurate mass and collision-induced dissociation mass spectrometry analyses of the metabolites supported proposed structures of MX and MY. In addition, MY was confirmed with a synthetic standard and detection of nitric oxide release when DB844 was incubated with CYP1A1. Taken altogether, we propose that MX is formed by insertion of an oxygen into the amidine C=N to form an oxaziridine, which is followed by intramolecular rearrangement of the adjacent O-methyl group and subsequent release of nitric oxide. The resulting imine ester, MX, is further hydrolyzed to form MY. These findings may contribute to furthering the understanding of toxicities associated with benzamidoxime- and benzmethamidoxime-containing molecules

Who Needs Inpatient Detox? Development and Implementation of a Hospitalist Protocol for the Evaluation of Patients for Alcohol Detoxification

BACKGROUND: Clinicians caring for patients seeking alcohol detoxification face many challenges, including lack of evidence-based guidelines for treatment and high recidivism rates. OBJECTIVES: To develop a standardized protocol for determining which alcohol dependent patients seeking detoxification need inpatient versus outpatient treatment, and to study the protocol's implementation. DESIGN: Review of best evidence by ad hoc task force and subsequent creation of standardized protocol. Prospective observational evaluation of initial protocol implementation. PARTICIPANTS: Patients presenting for alcohol detoxification. INTERVENTION: Development and implementation of a protocol for evaluation and treatment of patients requesting alcohol detoxification. MAIN MEASURES: Number of admissions per month with primary alcohol related diagnosis (DRG), 30-day readmission rate, and length of stay, all measured before and after protocol implementation. RESULTS: We identified one randomized clinical trial and three cohort studies to inform the choice of inpatient versus outpatient detoxification, along with one prior protocol in this population, and combined that data with clinical experience to create an institutional protocol. After implementation, the average number of alcohol related admissions was 15.9 per month, compared with 18.9 per month before implementation (p = 0.037). There was no difference in readmission rate or length of stay. CONCLUSIONS: Creation and utilization of a protocol led to standardization of care for patients requesting detoxification from alcohol. Initial evaluation of protocol implementation showed a decrease in number of admissions