Serum Antioxidant Associations with Metabolic Characteristics in Metabolically Healthy and Unhealthy Adolescents with Severe Obesity: An Observational Study

Considering the inadequacy of some antioxidant nutrients in severely obese adolescents, this study aimed to assess the relationship between antioxidant micronutrients status and metabolic syndrome components in metabolically healthy obesity (MHO) and unhealthy obesity (MUO). We performed an observational study in severely obese adolescents (body mass index > 99th percentile) and they were classified into MHO or MUO, according to the criteria adapted for adolescents. Anthropometric, biochemical, and clinical variables were analyzed to characterize the sample of adolescents. The serum antioxidant nutrients assessed were retinol, beta-carotene, Vitamin E, Vitamin C, zinc and selenium. A total of 60 adolescents aged 17.31 +/- 1.34 years were enrolled. MHO was identified in 23.3% of adolescents. The MHO group showed lower frequency of non-alcoholic fatty liver disease (14.3% vs. 78.3%, p < 0.001) when compared to MUO. A correlation was found between retinol and beta-carotene concentrations with glycemia (r = -0.372p = 0.011 and r = -0.314p = 0.034, respectively) and between Vitamin E with waist circumference (r = -0.306p = 0.038) in the MUO group. The current study shows that some antioxidant nutrients status, specifically retinol, beta-carotene, and Vitamin E, are negatively associated with metabolic alterations in MUO. Further studies are necessary to determine the existing differences in the serum antioxidant profile of metabolically healthy and unhealthy obese adolescents.Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) (Carlos Chagas Filho Foundation for Research Support of the State of Rio de Janeiro)Fed Univ Rio de Janeiro UFRJ, Sch Med, BR-21941902 Rio De Janeiro, BrazilUniv Fed Rio de Janeiro, Ctr Res Micronutrients NPqM, Inst Nutr Josue de Castro, BR-21941902 Rio de Janeiro, BrazilMultidisciplinary Ctr Bariatr & Metab Surg, BR-22280020 Rio De Janeiro, BrazilUniv Fed Rio de Janeiro, Dept Social & Appl Nutr, Inst Nutr, BR-21941902 Rio de Janeiro, BrazilFed Univ Sao Paulo UNIFESP, Escola Paulista Med, BR-04021001 Sao Paulo, BrazilFed Univ Sao Paulo UNIFESP, Escola Paulista Med, BR-04021001 Sao Paulo, BrazilWeb of Scienc

Study of Bc+B^+_c decays to the K+K−π+K^+K^-\pi^+ final state and evidence for the decay Bc+→χc0π+B^+_c\to\chi_{c0}\pi^+

A study of $B_c^+\to K^+K^-\pi^+$ decays is performed for the first time using data corresponding to an integrated luminosity of 3.0 $\mathrm{fb}^{-1}$ collected by the LHCb experiment in $pp$ collisions at centre-of-mass energies of $7$ and $8$ TeV. Evidence for the decay $B_c^+\to\chi_{c0}(\to K^+K^-)\pi^+$ is reported with a significance of 4.0 standard deviations, resulting in the measurement of $\frac{\sigma(B_c^+)}{\sigma(B^+)}\times\mathcal{B}(B_c^+\to\chi_{c0}\pi^+)$ to be $(9.8^{+3.4}_{-3.0}(\mathrm{stat})\pm 0.8(\mathrm{syst}))\times 10^{-6}$. Here $\mathcal{B}$ denotes a branching fraction while $\sigma(B_c^+)$ and $\sigma(B^+)$ are the production cross-sections for $B_c^+$ and $B^+$ mesons. An indication of $\overline b c$ weak annihilation is found for the region $m(K^-\pi^+)<1.834\mathrm{\,Ge\kern -0.1em V\!/}c^2$, with a significance of 2.4 standard deviations.A study of Bc+→K+K-π+ decays is performed for the first time using data corresponding to an integrated luminosity of 3.0  fb-1 collected by the LHCb experiment in pp collisions at center-of-mass energies of 7 and 8 TeV. Evidence for the decay Bc+→χc0(→K+K-)π+ is reported with a significance of 4.0 standard deviations, giving σ(Bc+)σ(B+)×B(Bc+→χc0π+)=(9.8-3.0+3.4(stat)±0.8(syst))×10-6. Here B denotes a branching fraction while σ(Bc+) and σ(B+) are the production cross sections for Bc+ and B+ mesons. An indication of b¯c weak annihilation is found for the region m(K-π+)<1.834  GeV/c2, with a significance of 2.4 standard deviations.A study of $B_c^+\to K^+K^-\pi^+$ decays is performed for the first time using data corresponding to an integrated luminosity of 3.0 $\mathrm{fb}^{-1}$ collected by the LHCb experiment in $pp$ collisions at centre-of-mass energies of $7$ and $8$ TeV. Evidence for the decay $B_c^+\to\chi_{c0}(\to K^+K^-)\pi^+$ is reported with a significance of 4.0 standard deviations, resulting in the measurement of $\frac{\sigma(B_c^+)}{\sigma(B^+)}\times\mathcal{B}(B_c^+\to\chi_{c0}\pi^+)$ to be $(9.8^{+3.4}_{-3.0}(\mathrm{stat})\pm 0.8(\mathrm{syst}))\times 10^{-6}$. Here $\mathcal{B}$ denotes a branching fraction while $\sigma(B_c^+)$ and $\sigma(B^+)$ are the production cross-sections for $B_c^+$ and $B^+$ mesons. An indication of $\bar b c$ weak annihilation is found for the region $m(K^-\pi^+)<1.834\mathrm{\,Ge\kern -0.1em V\!/}c^2$, with a significance of 2.4 standard deviations

Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry

IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes