93 research outputs found
Stretching the Inflaton Potential with Kinetic Energy
Inflation near a maximum of the potential is studied when non-local
derivative operators are included in the inflaton Lagrangian. Such terms can
impose additional sources of friction on the field. For an arbitrary spacetime
geometry, these effects can be quantified in terms of a local field theory with
a potential whose curvature around the turning point is strongly suppressed.
This implies that a prolonged phase of slow-roll inflation can be achieved with
potentials that are otherwise too steep to drive quasi-exponential expansion.
We illustrate this mechanism within the context of p-adic string theory.Comment: 4 page
The Andante Regime of Scalar Field Dynamics
The andante regime of scalar field dynamics in the chaotic inflationary
Universe is defined as the epoch when the field is rolling moderately slowly
down its interaction potential, but at such a rate that first-order corrections
to the slow-roll approximation become important. These conditions should apply
towards the end of inflation as the field approaches the global minimum of the
potential. Solutions to the Einstein-scalar field equations for the class of
power law potentials are found in this regime in
terms of the inverse error function.Comment: 11 pages of plain Latex, FNAL-Pub-94/226-
Star Formation at From the Spitzer Large Area Survey with Hyper-Suprime-Cam (SPLASH)
Using the first 50% of data collected for the Spitzer Large Area Survey with
Hyper-Suprime-Cam (SPLASH) observations on the 1.8 deg Cosmological
Evolution Survey (COSMOS) we estimate the masses and star formation rates of
3398 star-forming galaxies at with a
substantial population up to . We find that the
strong correlation between stellar mass and star formation rate seen at lower
redshift (the "main sequence" of star-forming galaxies) extends to .
The observed relation and scatter is consistent with a continued increase in
star formation rate at fixed mass in line with extrapolations from
lower-redshift observations. It is difficult to explain this continued
correlation, especially for the most massive systems, unless the most massive
galaxies are forming stars near their Eddington-limited rate from their first
collapse. Furthermore, we find no evidence for moderate quenching at higher
masses, indicating quenching either has not occurred prior to or
else occurs rapidly, so that few galaxies are visible in transition between
star-forming and quenched.Comment: ApJL, accepte
The No-Scale Multiverse at the LHC
We present a contemporary perspective on the String Landscape and the
Multiverse of plausible string, M- and F-theory vacua, seeking to demonstrate a
non-zero probability for the existence of a universe matching our own observed
physics within the solution ensemble, arguing for the importance of No-Scale
Supergravity as an essential common underpinning. Our context is a highly
detailed phenomenological probe of No-Scale F-SU(5), a model representing the
intersection of the F-lipped SU(5) X U(1)_X Grand Unified Theory (GUT) with
extra TeV-Scale vector-like multiplets derived out of F-theory, and the
dynamics of No-Scale Supergravity. We present a highly constrained "Golden"
region with tan(beta) \sim 15, m_t = 173.0 - 174.4 GeV, M_1/2 = 455 - 481 GeV,
and M_V = 691 - 1020 GeV, which simultaneously satisfies all known experimental
constraints. We supplement this bottom-up phenomenological perspective with a
top-down theoretical analysis of the one-loop effective Higgs potential,
achieving a striking consonance via the dynamic determination of tan(beta) and
M_1/2 at the local secondary minimization of the spontaneously broken
electroweak Higgs vacuum V_min. We present the distinctive signatures of
No-Scale F-SU(5) at the LHC, where a light stop and gluino are expected to
generate a surplus of ultra-high multiplicity (>= 9) hadronic jet events. We
propose modest alterations to the canonical background selection cut strategy
which would enhance resolution of these events, while readily suppressing the
contribution of all Standard Model processes, and allowing a clear
differentiation from competing models of new physics. Detection by the LHC of
the ultra-high jet signal would constitute a suggestive evocation of the
intimately linked stringy origins of F-SU(5), and could provide a glimpse into
the fundamental string moduli, and possibly even the workings of the No-Scale
Multiverse.Comment: A review of recent work, submitted to the DICE 2010 Workshop
proceedings, based on the invited talk by D.V.N. (20 Pages, 5 Tables, 18
Figures
Reconstructing the Inflaton Potential---in Principle and in Practice
Generalizing the original work by Hodges and Blumenthal, we outline a
formalism which allows one, in principle, to reconstruct the potential of the
inflaton field from knowledge of the tensor gravitational wave spectrum or the
scalar density fluctuation spectrum, with special emphasis on the importance of
the tensor spectrum. We provide some illustrative examples of such
reconstruction. We then discuss in some detail the question of whether one can
use real observations to carry out this procedure. We conclude that in
practice, a full reconstruction of the functional form of the potential will
not be possible within the foreseeable future. However, with a knowledge of the
dark matter components, it should soon be possible to combine
intermediate-scale data with measurements of large-scale cosmic microwave
background anisotropies to yield useful information regarding the potential.Comment: 39 pages plus 2 figures (upon request:[email protected]), LaTeX,
FNAL--PUB--93/029-A; SUSSEX-AST 93/3-
Antigen-Specific Single B Cell Sorting and Monoclonal Antibody Cloning in Guinea Pigs
Here, we have established an antigen-specific single B cell sorting and monoclonal antibody (mAb) cloning platform for analyzing immunization- or viral infection-elicited antibody response at the clonal level in guinea pigs. We stained the peripheral blood mononuclear cells (PBMCs) from a guinea pig immunized with HIV-1 envelope glycoprotein trimer mimic (BG505 SOSIP), using anti-guinea pig IgG and IgM fluorochrome conjugates, along with fluorochrome-conjugated BG505 SOSIP trimer as antigen (Ag) probe to sort for Ag-specific IgGhi IgMlo B cells at single cell density. We then designed a set of guinea pig immunoglobulin (Ig) gene-specific primers to amplify cDNAs encoding B cell receptor variable regions [V(D)J segments] from the sorted Ag-specific B cells. B cell V(D)J sequences were verified by sequencing and annotated by IgBLAST, followed by cloning into Ig heavy- and light-chain expression vectors containing human IgG1 constant regions and co-transfection into 293F cells to reconstitute full-length antibodies in a guinea pig-human chimeric IgG1 format. Of 88 antigen-specific B cells isolated, we recovered 24 (27%) cells with native-paired heavy and light chains. Furthermore, 85% of the expressed recombinant mAbs bind positively to the antigen probe by enzyme-linked immunosorbent and/or BioLayer Interferometry assays, while five mAbs from four clonal lineages neutralize the HIV-1 tier 1 virus ZM109. In summary, by coupling Ag-specific single B cell sorting with gene-specific single cell RT-PCR, our method exhibits high efficiency and accuracy, which will facilitate future efforts in isolating mAbs and analyzing B cell responses to infections or immunizations in the guinea pig model
First-order cosmological phase transitions in the radiation dominated era
We consider first-order phase transitions of the Universe in the
radiation-dominated era. We argue that in general the velocity of interfaces is
non-relativistic due to the interaction with the plasma and the release of
latent heat. We study the general evolution of such slow phase transitions,
which comprise essentially a short reheating stage and a longer phase
equilibrium stage. We perform a completely analytical description of both
stages. Some rough approximations are needed for the first stage, due to the
non-trivial relations between the quantities that determine the variation of
temperature with time. The second stage, instead, is considerably simplified by
the fact that it develops at a constant temperature, close to the critical one.
Indeed, in this case the equations can be solved exactly, including
back-reaction on the expansion of the Universe. This treatment also applies to
phase transitions mediated by impurities. We also investigate the relations
between the different parameters that govern the characteristics of the phase
transition and its cosmological consequences, and discuss the dependence of
these parameters with the particle content of the theory.Comment: 38 pages, 3 figures; v2: Minor changes, references added; v3: several
typos correcte
Baryon Acoustic Oscillations in the Sloan Digital Sky Survey Data Release 7 Galaxy Sample
The spectroscopic Sloan Digital Sky Survey (SDSS) Data Release 7 (DR7) galaxy
sample represents the final set of galaxies observed using the original SDSS
target selection criteria. We analyse the clustering of galaxies within this
sample, including both the Luminous Red Galaxy (LRG) and Main samples, and also
include the 2-degree Field Galaxy Redshift Survey (2dFGRS) data. Baryon
Acoustic Oscillations are observed in power spectra measured for different
slices in redshift; this allows us to constrain the distance--redshift relation
at multiple epochs. We achieve a distance measure at redshift z=0.275, of
r_s(z_d)/D_V(0.275)=0.1390+/-0.0037 (2.7% accuracy), where r_s(z_d) is the
comoving sound horizon at the baryon drag epoch,
D_V(z)=[(1+z)^2D_A^2cz/H(z)]^(1/3), D_A(z) is the angular diameter distance and
H(z) is the Hubble parameter. We find an almost independent constraint on the
ratio of distances D_V(0.35)/D_V(0.2)=1.736+/-0.065, which is consistent at the
1.1sigma level with the best fit Lambda-CDM model obtained when combining our
z=0.275 distance constraint with the WMAP 5-year data. The offset is similar to
that found in previous analyses of the SDSS DR5 sample, but the discrepancy is
now of lower significance, a change caused by a revised error analysis and a
change in the methodology adopted, as well as the addition of more data. Using
WMAP5 constraints on Omega_bh^2 and Omega_ch^2, and combining our BAO distance
measurements with those from the Union Supernova sample, places a tight
constraint on Omega_m=0.286+/-0.018 and H_0 = 68.2+/-2.2km/s/Mpc that is robust
to allowing curvature and non-Lambda dark energy. This result is independent of
the behaviour of dark energy at redshifts greater than those probed by the BAO
and supernova measurements. (abridged)Comment: 22 pages, 16 figures, minor changes to match version published in
MNRA
Distinct inhibitory effects on mTOR signaling by ethanol and INK128 in diffuse large B-cell lymphoma
Inflation, cold dark matter, and the central density problem
A problem with high central densities in dark halos has arisen in the context
of LCDM cosmologies with scale-invariant initial power spectra. Although n=1 is
often justified by appealing to the inflation scenario, inflationary models
with mild deviations from scale-invariance are not uncommon and models with
significant running of the spectral index are plausible. Even mild deviations
from scale-invariance can be important because halo collapse times and
densities depend on the relative amount of small-scale power. We choose several
popular models of inflation and work out the ramifications for galaxy central
densities. For each model, we calculate its COBE-normalized power spectrum and
deduce the implied halo densities using a semi-analytic method calibrated
against N-body simulations. We compare our predictions to a sample of dark
matter-dominated galaxies using a non-parametric measure of the density. While
standard n=1, LCDM halos are overdense by a factor of 6, several of our example
inflation+CDM models predict halo densities well within the range preferred by
observations. We also show how the presence of massive (0.5 eV) neutrinos may
help to alleviate the central density problem even with n=1. We conclude that
galaxy central densities may not be as problematic for the CDM paradigm as is
sometimes assumed: rather than telling us something about the nature of the
dark matter, galaxy rotation curves may be telling us something about inflation
and/or neutrinos. An important test of this idea will be an eventual consensus
on the value of sigma_8, the rms overdensity on the scale 8 h^-1 Mpc. Our
successful models have values of sigma_8 approximately 0.75, which is within
the range of recent determinations. Finally, models with n>1 (or sigma_8 > 1)
are highly disfavored.Comment: 13 pages, 6 figures. Minor changes made to reflect referee's
Comments, error in Eq. (18) corrected, references updated and corrected,
conclusions unchanged. Version accepted for publication in Phys. Rev. D,
scheduled for 15 August 200
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