Primakoff Physics for CERN COMPASS Hadron Beam: Hadron Polarizabilities, Hybrid Mesons, Chiral Anomaly, Meson Radiative Transitions

We describe a hadron physics program attainable with a partially instrumented CERN COMPASS spectrometer, involving tracking detectors and moderate-size ECAL2/HCAL2 calorimeters. COMPASS can realize a state-of-the-art hadron beam physics program based on hadron polarizability, hybrid mesons, chiral anomaly, and meson radiative transition studies. We review here the physics motivation for this hadron beam program. We describe the beam, detector, trigger requirements, and hardware/software requirements for this program. The triggers for all this physics can be implemented for simultaneous data taking. The program is based on using a hadron beam (positive/negative pion, kaon, proton) in COMPASS.Comment: Contribution to the Proceedings of the Charles U./JINR and International U. (Dubna) CERN COMPASS Summer School, Charles University, Prague, Czech Republic, August 1997, Eds. M. Chavleishvili and M. Finger Tel Aviv U. Preprint TAUP TAUP-2473-98. 26 pages, 11 figures, late

Hadron-Photon Interactions in COMPASS

The COMPASS experiment at CERN SPS will use hadron beams (pion, kaon and proton) and muons at 50-280 GeV/c and virtual photon targets to investigate, via Primakoff effect, important hadron properties: polarizability, chiral anomaly, radiative transitions and hybrid meson production. We present simulation studies to optimize the beam, detector setup and trigger for measuring with high statistics above topics.Comment: 10 pages, 3 figures, 3 macro

Effect of heating and cooling of photogenerated electron-hole plasma in optically pumped graphene on population inversion

We study the characteristics of photogenerated electron-hole plasma in optically pumped graphene layers at elevated (room) temperatures when the interband and intraband processes of emission and absorption of optical phonons play a crucial role. The electron-hole plasma heating and cooling as well as the effect of nonequilibrium optical phonons are taken into account. % The dependences of the quasi-Fermi energy and effective temperature of optically pumped graphene layers on the intensity of pumping radiation are calculated. The variation of the frequency dependences dynamic conductivity with increasing pumping intensity as well as the conditions when this conductivity becomes negative in a certain range of frequencies are considered. % The effects under consideration can markedly influence the achievement of the negative dynamic conductivity in optically pumped graphene layers associated with the population inversion and, hence, the realization graphene-based terahertz and infrared lasers operating at room temperatures.Comment: 12 pages, 7 figure

Ekstraksi Dna Dan Amplifikasi Its Rdna Isolat Fungi Endofit Lbkurcc67 Umbi Tanaman Dahlia (Dahlia Variabilis)

> Endophyte fungi lives in the plant tissues without causing harm to their host and has known that can produce secondary metabolite and extracellular enzyme. Fungi LBKURCC67 is an endophyte fungi that was isolated from tubers of yellow flowered Dahlia variabilis in Padang Panjang, West Sumatera. Species of fungi LBKURCC67 isolate was not known exactly because the morphology identification has been previously is appropriate for genus level. The accurate identification to known species is molecular with phylogenetic analysis. Before determine species in molecular analysis, it must extraction and amplification DNA. This research aims to optimation of DNA extraction and rDNA amplification in Internal Transcribed Spacer (ITS) regions with Polymerase Chain Reactions (PCR) methods. The DNA of fungi LBKURCC67 isolate was extract with Wizard Genomic DNA Purification kit ex Promega Corp. (Madison, USA) from cultur mycelium. The result shows extraction DNA was success from fourth days mycelia. Optimum condition for rDNA amplification with PCR were used ITS5 and ITS4 primers and 41°C annealing temperature. Electrophoresis analysis shows molecular weight of DNA isolate is 16.951 bp and molecular weight of PCR product is 583 bp

ESTRO-ACROP guideline on surface guided radiation therapy

Surface guidance systems enable patient positioning and motion monitoring without using ionising radiation. Surface Guided Radiation Therapy (SGRT) has therefore been widely adopted in radiation therapy in recent years, but guidelines on workflows and specific quality assurance (QA) are lacking. This ESTRO-ACROP guideline aims to give recommendations concerning SGRT roles and responsibilities and highlights common challenges and potential errors. Comprehensive guidelines for procurement, acceptance, commissioning, and QA of SGRT systems installed on computed tomography (CT) simulators, C-arm linacs, closed-bore linacs, and particle therapy treatment systems are presented that will help move to a consensus among SGRT users and facilitate a safe and efficient implementation and clinical application of SGRT. Keywords: ACROP; ESTRO; Guideline; SGRT; Surface guided radiation therapy

HCoV- and SARS-CoV-2 Cross-Reactive T Cells in CVID Patients

The inability of patients with CVID to mount specific antibody responses to pathogens has raised concerns on the risk and severity of SARS-CoV-2 infection, but there might be a role for protective T cells in these patients. SARS-CoV-2 reactive T cells have been reported for SARS-CoV-2 unexposed healthy individuals. Until now, there is no data on T cell immunity to SARS-CoV-2 infection in CVID. This study aimed to evaluate reactive T cells to human endemic corona viruses (HCoV) and to study pre-existing SARS-CoV-2 reactive T cells in unexposed CVID patients. We evaluated SARS-CoV-2- and HCoV-229E and -OC43 reactive T cells in response to seven peptide pools, including spike and nucleocapsid (NCAP) proteins, in 11 unexposed CVID, 12 unexposed and 11 post COVID-19 healthy controls (HC). We further characterized reactive T cells by IFNγ, TNFα and IL-2 profiles. SARS-CoV-2 spike-reactive CD4+ T cells were detected in 7 of 11 unexposed CVID patients, albeit with fewer multifunctional (IFNγ/TNFα/IL-2) cells than unexposed HC. CVID patients had no SARS-CoV-2 NCAP reactive CD4+ T cells and less reactive CD8+ cells compared to unexposed HC. We observed a correlation between T cell reactivity against spike of SARS-CoV-2 and HCoVs in unexposed, but not post COVID-19 HC, suggesting cross-reactivity. T cell responses in post COVID-19 HC could be distinguished from unexposed HC by higher frequencies of triple-positive NCAP reactive CD4+ T cells. Taken together, SARS-CoV-2 reactive T cells are detectable in unexposed CVID patients albeit with lower recognition frequencies and polyfunctional potential. Frequencies of triple-functional reactive CD4+ cells might provide a marker to distinguish HCoV cross-reactive from SARS-CoV-2 specific T cell responses. Our data provides evidence, that anti-viral T cell immunity is not relevantly impaired in most CVID patients

Disease Severity, Fever, Age, and Sex Correlate With SARS-CoV-2 Neutralizing Antibody Responses

Clinical trials on the use of COVID-19 convalescent plasma remain inconclusive. While data on safety is increasingly available, evidence for efficacy is still sparse. Subgroup analyses hint to a dose-response relationship between convalescent plasma neutralizing antibody levels and mortality. In particular, patients with primary and secondary antibody deficiency might benefit from this approach. However, testing of neutralizing antibodies is limited to specialized biosafety level 3 laboratories and is a time- and labor-intense procedure. In this single center study of 206 COVID-19 convalescent patients, clinical data, results of commercially available ELISA testing of SARS-CoV-2 spike-IgG and -IgA, and levels of neutralizing antibodies, determined by plaque reduction neutralization testing (PRNT), were analyzed. At a medium time point of 58 days after symptom onset, only 12.6% of potential plasma donors showed high levels of neutralizing antibodies (PRNT50 >= 1:320). Multivariable proportional odds logistic regression analysis revealed need for hospitalization due to COVID-19 (odds ratio 6.87; p-value 0.0004) and fever (odds ratio 3.00; p-value 0.0001) as leading factors affecting levels of SARS-CoV-2 neutralizing antibody titers in convalescent plasma donors. Using penalized estimation, a predictive proportional odds logistic regression model including the most important variables hospitalization, fever, age, sex, and anosmia or dysgeusia was developed. The predictive discrimination for PRNT50 >= 1:320 was reasonably good with AUC: 0.86 (with 95% CI: 0.79-0.92). Combining clinical and ELISA-based pre-screening, assessment of neutralizing antibodies could be spared in 75% of potential donors with a maximal loss of 10% of true positives (PRNT50 >= 1:320)