Apocynin: Molecular Aptitudes

Apocynin is a naturally occurring methoxy-substituted catechol, experimentally used as an inhibitor of NADPH-oxidase. It can decrease the production of superoxide (O2−) from activated neutrophils and macrophages while the ability of phagocytosis remains unaffected. The anti-inflammatory activity of apocynin has been demonstrated in a variety of cell and animal models of inflammation. Apocynin, after metabolic conversion, inhibits the assembly of NADPH-oxidase that is responsible for reactive oxygen species (ROS) production. It is, therefore, extensively used to reveal the role of this enzyme in cell and experimental models. Although some of the ROS serve as signaling molecules in the cells, excessive production is damaging and has been implicated to play an important role in the progression of many disease processes. This is why in many studies apocynin presents a promising potential treatment for some disorders; however, its utility with inflammatory diseases remains to be determined. Since its mode of action is not well defined, we tried to get a more precise insight into the mechanisms by which apocynin exerts its activity. Considering the anti-inflammatory activities of apocynin, we may conclude that this compound definitely deserves further study

Whiter Than White: The Art of Delaying Detection in Sexual Killers

The study investigated whether different types of sexual homicide perpetrators are more or less skilled at delaying detection. Using the newly proposed direct/indirect typology, the time of arrest, the frequency of specific precautions as well as the impact of forensic strategies used by the perpetrators were examined. The results indicated that the time from the killing to the arrest, as measured in days, was longer for the direct than the indirect sexual killers. Despite the fact that the direct aggressors were better at delaying detection, overall the indirect and the direct offenders did not differ in the frequency of use of most of the precautions. However, different forensic awareness strategies were more efficacious for the direct and the indirect offenders. These results are discussed in relation to the crime scripts for the two perpetrator groups

Mental Disorders Related to Stroke

Stroke is third most common cause of death and the most common reason for disability in people over 45 years old. It impacts people in social and economic aspects. As a result of stroke, patients struggle to function in everyday life, they often require rehabilitation as they are limited in the way they can move. Experts reckon that the most serious complications after stroke are problems with cognitive functions and depression (1). Very often there is more attention paid to deficit of mobility or speech than cognitive function problems or depression. Stupor occurs in 1/3 of patients that experienced stroke

Meta-Analysis of DNA Methylation and Expression in Liver Cancer Patients

Hepatocellular carcinoma (HCC), the most common liver cancer, is the second leading cause of cancer-related death worldwide. HCC is often diagnosed at late stages, for which there are no effective chemotherapies. Biomarkers unique to HCC patients could be used to detect HCC early and improve treatment. In the present project, we have performed a meta-analysis to compare the gene-specific DNA methylation and gene expression patterns of HCC patients as reported by four independent studies. Our goal was to discover the strongest changes that distinguish HCC from normal tissue. The relationship between methylation and expression in HCC was examined and genes epigenetically regulated in HCC were identified. The top changes within genes, gene families and pathways could be of interest in further investigations of potential HCC biomarkers. A significant correlation between DNA hypomethylation and gene activation and between DNA hypermethylation and gene silencing was found. CpG islands, commonly found in promoter regions, are predominantly hypermethylated in HCC, while CpGs outside of CpG islands are predominantly hypomethylated in gene bodies. 149 genes were found to be significantly differentially methylated between tumors and normal adjacent tissue, and 169 genes were found to be significantly differentially expressed. Genes identified for further research are GNG7, WNT5B, RXRG, HOXB7, and SMARCB1. No overlap was found between differentially expressed and methylated genes. Nevertheless, common gene families and pathways were identified where more potential biomarkers could be found in future studies