Akagi

Allen

Arora

Ayala

Barnes

Cadamuro

Castor

Chandan

Connell

Conway

de Almeida

Dunn

Elfvin

Eruslanov

Ghosh

Guang

Gustavson

Handa

Hardbower

Harsha

Hougee

Kennett

Lafeber

Lull

Malfertheiner

McManus

Mózsik

Müller

Pedroso

Philippens

Rodriguez

Rubin

Stefanska

Tang

Umamaheshwari

Wang

Wiedemann

Yamazaki

Zhang

Zhao

English

Abstract: The emergence of antibiotic-resistant Helicobacter pylori strains impacts the efficacy of eradication therapy and promotes the development of alternative treatment strategies. Apocynin inhibits neutrophil NADPH oxidase and hence may decrease reactive oxygen species-mediated tissue damage in H. pylori-infected stomach tissue. Apocynin was tested in vitro for its cytotoxic and direct antibacterial effects. The therapeutic efficacy of orally administered apocynin (100 mg/kg/day through drinking water or 200 mg/kg/day through combined administration of drinking water and slow-release formulation) was assessed at 9 weeks after infection in the Mongolian gerbil model. Bacterial burdens were quantified by viable plate count and quantitative PCR. Histopathological evaluation of antrum and pylorus provided insight into mucosal inflammation and injury. Apocynin showed no cytotoxic or direct antibacterial effects in vitro or in vivo. Nine weeks of apocynin treatment at 200 mg/kg/day reduced active H. pylori gastritis as neutrophil infiltration in the mucous neck region and pit abscess formation decreased significantly. In our gerbil model, prolonged high-dose apocynin treatment significantly improved H. pylori-induced pit abscess formation without indications of drug toxicity and thus further investigation of the dosage regimen and formulation and the long-term impact on neoplastic development should be carried out

Horemans, Tessa

Boulet, Ga\ueblle A.V.

Van kerckhoven, Marian

Bogers, Johannes J.P.M.

Thys, Sofie

Vervaet, Chris

Vervaeck, Anouck

Delputte, Peter

Maes, Louis

Cos, Paul

Institutional Repository Universiteit Antwerpen

In-vivo evaluation of apocynin for prevention of Helicobacter pylori-induced gastric carcinogenesis

In-vivo evaluation of apocynin for prevention of Helicobacter pylori-induced gastric carcinogenesis

Abstract

Similar works

Full text

Available Versions

Institutional Repository Universiteit Antwerpen

Crossref

Ghent University Academic Bibliography