5,228 research outputs found
Applications of Partial Supersymmetry
I examine quantum mechanical Hamiltonians with partial supersymmetry, and
explore two main applications. First, I analyze a theory with a logarithmic
spectrum, and show how to use partial supersymmetry to reveal the underlying
structure of this theory. This method reveals an intriguing equivalence between
two formulations of this theory, one of which is one-dimensional, and the other
of which is infinite-dimensional. Second, I demonstrate the use of partial
supersymmetry as a tool to obtain the asymptotic energy levels in
non-relativistic quantum mechanics in an exceptionally easy way. In the end, I
discuss possible extensions of this work, including the possible connections
between partial supersymmetry and renormalization group arguments.Comment: 11 pages, harvmac, no figures; typo corrected in identifying info on
title pag
MALAT1 Long Non-Coding RNA: Functional Implications
The mammalian genome is pervasively transcribed and the functional significance of many long non-coding RNA (lncRNA) transcripts are gradually being elucidated. Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is one of the most well-studied lncRNAs. MALAT1 is a highly conserved nuclear retained lncRNA that is abundantly expressed in cells and tissues and has been shown to play a role in regulating genes at both the transcriptional and post-transcriptional levels in a context-dependent manner. However, Malat1 has been shown to be dispensable for normal development and viability in mice. Interestingly, accumulating evidence suggests that MALAT1 plays an important role in numerous diseases including cancer. Here, we discuss the current state-of-knowledge in regard to MALAT1 with respect to its function, role in diseases, and the potential therapeutic opportunities for targeting MALAT1 using antisense oligonucleotides and small molecules
Johnson-Kendall-Roberts theory applied to living cells
Johnson-Kendall-Roberts (JKR) theory is an accurate model for strong adhesion
energies of soft slightly deformable material. Little is known about the
validity of this theory on complex systems such as living cells. We have
addressed this problem using a depletion controlled cell adhesion and measured
the force necessary to separate the cells with a micropipette technique. We
show that the cytoskeleton can provide the cells with a 3D structure that is
sufficiently elastic and has a sufficiently low deformability for JKR theory to
be valid. When the cytoskeleton is disrupted, JKR theory is no longer
applicable
Genome-wide association studies identify multiple genetic loci influencing eyebrow color variation in Europeans
Investigating the timecourse of accessing conversational implicatures during incremental sentence interpretation
Many contextual inferences in utterance interpretation are explained as following from the nature of conversation and the assumption that participants are rational. Recent psycholinguistic research has focussed on certain of these âGriceanâ inferences and have revealed that comprehenders can access them in online interpretation. However there have been mixed results as to the time-course of access. Some results show that Gricean inferences can be accessed very rapidly, as rapidly as any other contextually specified information (Sedivy, 2003; Grodner, Klein, Carbery, & Tanenhaus, 2010); while other studies looking at the same kind of inference suggest that access to Gricean inferences are delayed relative to other aspects of semantic interpretation (Huang & Snedeker, 2009; in press). While previous timecourse research has focussed on Gricean inferences that support the online assignment of reference to definite expressions, the study reported here examines the timecourse of access to scalar implicatures, which enrich the meaning of an utterance beyond the semantic interpretation. Even if access to Gricean inference in support of reference assignment may be rapid, it is still unknown whether genuinely enriching scalar implicatures are delayed. Our results indicate that scalar implicatures are accessed as rapidly as other contextual inferences. The implications of our results are discussed in reference to the architecture of language comprehension
Evidence for a nuclear compartment of transcription and splicing located at chromosome domain boundaries
The nuclear topography of splicing snRNPs, mRNA transcripts and chromosome domains in various mammalian cell types are described. The visualization of splicing snRNPs, defined by the Sm antigen, and coiled bodies, revealed distinctly different distribution patterns in these cell types. Heat shock experiments confirmed that the distribution patterns also depend on physiological parameters. Using a combination of fluorescencein situ hybridization and immunodetection protocols, individual chromosome domains were visualized simultaneously with the Sm antigen or the transcript of an integrated human papilloma virus genome. Three-dimensional analysis of fluorescence-stained target regions was performed by confocal laser scanning microscopy. RNA transcripts and components of the splicing machinery were found to be generally excluded from the interior of the territories occupied by the individual chromosomes. Based on these findings we present a model for the functional compartmentalization of the cell nucleus. According to this model the space between chromosome domains, including the surface areas of these domains, defines a three-dimensional network-like compartment, termed the interchromosome domain (ICD) compartment, in which transcription and splicing of mRNA occurs
Revisiting Expectations in an Era of Precision Oncology
As we enter an era of precision medicine and targeted therapies in the treatment of metastatic cancer, we face new challenges for patients and providers alike as we establish clear guidelines, regulations, and strategies for implementation. At the crux of this challenge is the fact that patients with advanced cancer may have disproportionate expectations of personal benefit when participating in clinical trials designed to generate generalizable knowledge. Patient and physician goals of treatment may not align, and reconciliation of their disparate perceptions must be addressed. However, it is particularly challenging to manage a patientâs expectations when the goal of precision medicineĂą personalized responseĂą exacerbates our inability to predict outcomes for any individual patient. The precision medicine informed consent process must therefore directly address this issue. We are challenged to honestly, clearly, and compassionately engage a patient population in an informed consent process that is responsive to their vulnerability, as well as everĂą evolving indications and evidence. This era requires a continual reassessment of expectations and goals from both sides of the bed.New challenges are faced in this era of precision medicine and targeted therapies. Clear guidelines, regulations, and strategies for implementation are needed. Patients with advanced cancer may have disproportionate expectations of the personal benefit of participating in clinical trials. The informed consent process must address this issue directly and honestly. This era requires a continual reassessment of both patient and physician expectations and goals.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142968/1/onco12322_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142968/2/onco12322.pd
Shape Invariance in the Calogero and Calogero-Sutherland Models
We show that the Calogero and Calogero-Sutherland models possess an N-body
generalization of shape invariance. We obtain the operator representation that
gives rise to this result, and discuss the implications of this result,
including the possibility of solving these models using algebraic methods based
on this shape invariance. Our representation gives us a natural way to
construct supersymmetric generalizations of these models, which are interesting
both in their own right and for the insights they offer in connection with the
exact solubility of these models.Comment: Latex file, 23 pages, no picture
A quantum genetic algorithm with quantum crossover and mutation operations
In the context of evolutionary quantum computing in the literal meaning, a
quantum crossover operation has not been introduced so far. Here, we introduce
a novel quantum genetic algorithm which has a quantum crossover procedure
performing crossovers among all chromosomes in parallel for each generation. A
complexity analysis shows that a quadratic speedup is achieved over its
classical counterpart in the dominant factor of the run time to handle each
generation.Comment: 21 pages, 1 table, v2: typos corrected, minor modifications in
sections 3.5 and 4, v3: minor revision, title changed (original title:
Semiclassical genetic algorithm with quantum crossover and mutation
operations), v4: minor revision, v5: minor grammatical corrections, to appear
in QI
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