2,486 research outputs found
Genetic continuity of brood-parasitic indigobird species
Speciation in brood-parasitic indigobirds (genus Vidua ) is a consequence of behavioural imprinting in both males and females. Mimicry of host song by males and host fidelity in female egg laying result in reproductive isolation of indigobirds associated with a given host species. Colonization of new hosts and subsequent speciation require that females occasionally lay eggs in the nests of novel hosts but the same behaviour may lead to hybridization when females parasitize hosts already associated with other indigobird species. Thus, retained ancestral polymorphism and ongoing hybridization are two alternative explanations for the limited genetic differentiation among indigobird species. We tested for genetic continuity of indigobird species using mitochondrial sequences and nuclear microsatellite data. Within West Africa and southern Africa, allopatric populations of the same species are generally more similar to each other than to sympatric populations of different species. Likewise, a larger proportion of genetic variation is explained by differences between species than by differences between locations in alternative hierarchical amovas, suggesting that the rate of hybridization is not high enough to homogenize sympatric populations of different species or prevent genetic differentiation between species. Broad sharing of genetic polymorphisms among species, however, suggests that some indigobird species trace to multiple host colonization events in space and time, each contributing to the formation of a single interbreeding population bound together by songs acquired from the host species.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75693/1/j.1365-294X.2005.02492.x.pd
Toxicity of mycotoxins for the rat pulmonary macrophage in vitro.
The presence of mycotoxins in grains is well documented. Workers in grain handling occupations are commonly exposed to grain dust aerosols. Work in our laboratory has shown that T-2 toxin is highly toxic to rat alveolar macrophages in vitro, causing loss of viability, release of radiolabeled chromium, inhibition of macromolecular synthesis, inhibition of phagocytosis, and inhibition of macrophage activation. Similarly, patulin caused a significant release of radiolabeled chromium, decrease in ATP levels, significant inhibition of protein and RNA synthesis, and inhibition of phagocytosis. The data show that both T-2 toxin and patulin are highly toxic to rat alveolar macrophages in vitro. The data further suggest that the presence of these mycotoxins in airborne respirable dust might present a hazard to exposed workers
Behavioural and genetic evidence of a recent population switch to a novel host species in brood-parasitic indigobirds Vidua chalybeata
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73593/1/j.1474-919X.2002.00065.x.pd
Bragg spectroscopy of a cigar shaped Bose condensate in optical lattices
We study properties of excited states of an array of weakly coupled
quasi-two-dimensional Bose condensates by using the hydrodynamic theory. We
calculate multibranch Bogoliubov-Bloch spectrums and its corresponding
eigenfunctions. The spectrum of the axial excited states and its eigenfunctions
strongly depends on the coupling among various discrete radial modes within a
given symmetry. This mode coupling is due to the presence of radial trapping
potential. The multibranch nature of the Bogoliubov-Bloch spectrum and its
dependence on the mode-coupling can be realized by analyzing dynamic structure
factor and momentum transferred to the system in Bragg spectroscopy
experiments. We also study dynamic structure factor and momentum transferred to
the condensate due to the Bragg spectroscopy experiment.Comment: 7 pages, 5 figures, to appear in Journal of Physics B: Atomic,
Molecular & Optical Physic
Dynamic optical lattices: two-dimensional rotating and accordion lattices for ultracold atoms
We demonstrate a novel experimental arrangement which rotates a 2D optical
lattice at frequencies up to several kilohertz. Ultracold atoms in such a
rotating lattice can be used for the direct quantum simulation of strongly
correlated systems under large effective magnetic fields, allowing
investigation of phenomena such as the fractional quantum Hall effect. Our
arrangement also allows the periodicity of a 2D optical lattice to be varied
dynamically, producing a 2D accordion lattice.Comment: 7 pages, 5 figures, final versio
Does coevolution promote species richness in parasitic cuckoos?
Why some lineages have diversified into larger numbers of species than others is a fundamental but still relatively poorly understood aspect of the evolutionary process. Coevolution has been recognized as a potentially important engine of speciation, but has rarely been tested in a comparative framework. We use a comparative approach based on a complete phylogeny of all living cuckoos to test whether parasiteāhost coevolution is associated with patterns of cuckoo species richness. There are no clear differences between parental and parasitic cuckoos in the number of species per genus. However, a cladogenesis test shows that brood parasitism is associated with both significantly higher speciation and extinction rates. Furthermore, subspecies diversification rate estimates were over twice as high in parasitic cuckoos as in parental cuckoos. Among parasitic cuckoos, there is marked variation in the severity of the detrimental effects on host fitness; chicks of some cuckoo species are raised alongside the young of the host and others are more virulent, with the cuckoo chick ejecting or killing the eggs/young of the host. We show that cuckoos with a more virulent parasitic strategy have more recognized subspecies. In addition, cuckoo species with more recognized subspecies have more hosts. These results hold after controlling for confounding geographical effects such as range size and isolation in archipelagos. Although the power of our analyses is limited by the fact that brood parasitism evolved independently only three times in cuckoos, our results suggest that coevolutionary arms races with hosts have contributed to higher speciation and extinction rates in parasitic cuckoos
Adenosine Receptors Expression in Human Retina and Choroid with Age-related Macular Degeneration
Purpose: Adenosine signaling modulates ocular inflammatory processes, and its antagonism mitigates neovascularization in both newborns and preclinical models of ocular neovascularization including age-related macular degeneration (AMD). The adenosine receptor expression patterns have not been well characterized in the human retina and choroid. Methods: Here we examined the expression of adenosine receptor subtypes within the retina and choroid of human donor eyes with and without AMD. Antibodies specifically targeting adenosine receptor subtypes A1, A2A, A2B, and A3 were used to assess their expression patterns. Quantitative real-time PCR analysis was used to confirm gene expression of these receptors within the normal human retina and choroid. Results: We found that all four receptor subtypes were expressed in several layers of the retina, and within the retinal pigment epithelium and choroid. The expression of A1 receptors was more prominent in the inner and outer plexiform layers, where microglia normally reside, and supported by RNA expression in the retina. A2A and A2B showed similar expression patterns with prominent expression in the vasculature and retinal pigment epithelium. No dramatic differences in expression of these receptors were observed in eyes from patients with dry or wet AMD compared to control, with the exception A3 receptors. Eyes with dry AMD lost expression of A3 in the photoreceptor outer segments compared with eyes from control or wet AMD. Conclusion: The ocular presence of adenosine receptors is consistent with their proposed role in modulation of inflammation in both the retina and choroid, and their potential targeting for AMD treatment
Transmission Properties of the oscillating delta-function potential
We derive an exact expression for the transmission amplitude of a particle
moving through a harmonically driven delta-function potential by using the
method of continued-fractions within the framework of Floquet theory. We prove
that the transmission through this potential as a function of the incident
energy presents at most two real zeros, that its poles occur at energies
(), and that the
poles and zeros in the transmission amplitude come in pairs with the distance
between the zeros and the poles (and their residue) decreasing with increasing
energy of the incident particle. We also show the existence of non-resonant
"bands" in the transmission amplitude as a function of the strength of the
potential and the driving frequency.Comment: 21 pages, 12 figures, 1 tabl
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