Progressive degeneration of dopamine system functions after transient cerebral oligemia in rats.

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Morbus Parkinson und andere Basalganglienerkrankungen. Neurotoxine und Neuroprotektion: Membranabhaengige radikalische Prozesse - Bedeutung fuer die Aetiologie und Therapie des Parkinson-Syndroms Schlussbericht

During the past three years (1992-1994), the main goal of our research work was to contribute to the elucidation of the etiology of Parkinson's disease (PD) and to elaborate new therapeutical strategies. Using classical neurotoxins (MPTP, 6-OHDA), a rat model was established that allows the investigation of the neurotoxic potential of compounds relevant for the etiology of PD. The studies revealed Fe-III as the only hitherto known neurotoxin that leads to a progredient loss of dopaminergic activity in the striatum. For highly halogenated #beta#-carbolines, especailly for the potentially endogenously occurring #beta#-carboline TaClo, a distinct neurotoxic activity could also be observed. This chloral-derived heterocycle was meanwhile established as a lead structure for a whole series of further highly active compounds. Investigations using old rats showed the presence of two groups of animals with a distinctly different sensitivity towards neurotoxins. In the PD iron model the lazaroid U-74389G was found to be an efficient neuroprotective. In an in vitro model likewise phosphatidyl serine, #alpha#-tocopherol, acetylsalicyclic acid and liponic acid showed protective activities. (orig.)SIGLEAvailable from TIB Hannover: F96B563+a / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung, Wissenschaft, Forschung und Technologie, Bonn (Germany)DEGerman

Entwicklung faseroptischer Messverfahren fuer den Einsatz als In-line-Geraet in Wiederaufarbeitungsanlagen

SIGLETIB Hannover: FR 3022 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Neurotoxine und Neuroprotektion: Bedeutung radikalischer Mechanismen und der Atmungsketteninhibition fuer die Aetiologie des Parkinsonsyndroms, der Neurodegeneration und des Alterungsprozesses Schlussbericht

There are no animal models for the investigation of the causes and progression of neurodegenerative diseases - such as Parkinson's Disease -suitable for searching out the pathological mechanisms which may elicit and maintain a progressive disease process. Up till now only a few of the factors that might contribute to the multiactorial pathogenesis of Parkinson's Disease have been established. A large-scale depolyment of non-human primates could not be considered. Rats, subjected to oxidative stress, exhibit a gradually developing assortment of pathological symptoms which strikingly involve the mediation of the dopaminergic system. The pathological symptoms are susceptible to therapeutic interventions. The animals undergo various stages of a set of pathological symptoms which manifests itself among others in a reluctance to undertake changes of rapid motor strategies. They exhibit a diminished ability to learn and to pay attention. Brain regions where such lesions may be elicited are highly specific. At an advanced age, the consequency of oxidative stress show a loss of the D1 mRNA in the dorsal statum without concomitant cell loss. (orig.)Available from TIB Hannover: F99B1195 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekSIGLEBundesministerium fuer Bildung und Forschung (BMBF), Bonn (Germany)DEGerman

Emotion dysregulation between mothers, fathers, and adolescents: Implications for adolescents' internalizing problems

Introduction The present study calls attention to the longitudinal relations between mothers', fathers', and adolescents' emotion dysregulation and adolescents' internalizing problems. To this end, we tested the associations between family members' emotion dysregulation and adolescents' internalizing problems over time. Methods Over a 12-month period, 386 Chinese families from Hong Kong involving mothers, fathers, and adolescent children (children at 12–17 years of age; boys = 185, girls = 201) completed a set of questionnaires twice. Results Multi-group path analysis revealed unidirectional effects of mothers' emotion dysregulation on fathers' and adolescents' emotion dysregulation over time. Adolescents' emotion dysregulation was also related to their subsequent internalizing problems. The associations did not differ as a function of adolescents' gender. Conclusion The present findings underscore the significance of mothers' emotion dysregulation on fathers' and adolescents' emotion dysregulation. As a risk factor, adolescents' emotion dysregulation was also predictive of their internalizing problems 12 months later. Taken together, this study serves to inform prevention and intervention efforts in promoting emotion regulation as a family asset associated with fewer adolescents' internalizing problems