Complementarity means of training in vocational education

Teacher complementary embedded in learning tools, considering the ratio of students to educational and scientific literature; student-generated intangible component due to the educational environmentПреподаватель комплементарно встраивается в систему средств обучения, учитывая отношение студентов к учебной и научной литературе; формируется личностно-обусловленный нематериальный компонент образовательной сред

Development of Social Innovations in Russia in Terms of Activities and Interaction of Government Bodies, Business Structures, and Civil Society

Due to growing global socio-economic and environmental challenges (population ageing, climate change, society polarization, etc.), there is a revaluation of a position and role of innovations in overcoming threats to social development in the modern world. Researchers note a shift in the innovation paradigm toward social innovation, since it is assumed that it is not possible to achieve a drastic improvement of the situation solely through technological innovations. At the same time, many existing problems cannot be solved with efforts of a single actor - intersectoral cooperation becomes a necessity. This aspect is of key importance for development of social innovation. The purpose of the study was to analyze development of social innovations in the Russian Federation based on an actor approach, which involves an overview of this phenomenon through the prism of activities of various entities and their interaction. General scientific methods were used in the study: discourse analysis, generalization, comparison, etc. Essential foundations and the role of social innovations in solving current society's problems are presented. Using the example of government structures, big business, and civil society, the authors explore the features of social innovation development in Russia. It is shown that development of social innovations depends on their interpretation in public discourse, involvement in strategies of various actors, and intersectoral cooperation in the innovation process. In conclusion, the prospects for development of studied phenomenon are determined within identified trends and the specifics of interconnections between designated actors. The results obtained may be used not only as an empirical basis for further research, but they may also represent practical significance in development of specific management decisions in this area

Efficacy of olocizumab in treatment of COVID-19 patients

Background. Production of pro-inflammatory cytokines including interleukin 6 (IL-6) is activated in COVID-19. Using olokizumab which inhibits IL-6 production in treatment of COVID-19 is pathogenetically justified.The aim. To study in real clinical practice the efficacy and safety of using the IL-6inhibitor (olokizumab) in treatment of patients with confirmed COVID-19 pneumonia.Materials and methods. The first group included 41 hospitalized patients with confirmed COVID-19 pneumonia having complex therapy including olokizumab. The control group consisted of 66 patients with confirmed COVID-19 pneumonia who did not have therapy with IL-6 inhibitor. We analyzed clinical (volume of lung involvement, respiratory failure degree, body mass index) and laboratory data (levels of T-troponin, lactate, procalcitonin, natriuretic peptide, C-reactive protein, fibrinogen, D-dimer, ferritin, erythrocyte sedimentation rate, glomerular filtration rate).Results. The groups did not differ in gender, age, body mass index of patients, volume of lung tissue injury, and duration of hospitalization (p > 0.05). Respiratory failure of 2–3rd degree was more common in patients of the first group (χ2 = 6.3; p = 0.010). The initial levels of C-reactive protein (50.9 [34.2; 76.2] and 32.2 [9.9; 69.1] mg/L respectively; p = 0.009) and fibrinogen (6.0 [5.3; 6.7] and 5.2 [4.3; 6.2] g/l respectively; p = 0.005) in patients having therapy including olokizumab were significantly higher than in the control group. The levels of erythrocyte sedimentation rate, fibrinogen and ferritin, D-dimer, detected upon admission of patients to the hospital, didn’t have statistically significant differences. At discharge, the erythrocyte sedimentation rate in patients receiving olokizumab was statistically significantly lower (9.0 [5.5; 14.5] and 13.0 [7.0; 27.0] mm/h; p = 0.018).Conclusions. Using olokizumab in the treatment patient with COVID-19 pneumonia has demonstrated a positive effect on clinical and laboratory parameters (erythrocyte sedimentation rate, fibrinogen level) in patients with pronounced inflammatory changes and respiratory impairment

Digital Transformation of Russia’s Agricultural Sector

The paper presents a methodical approach to the assessment of agricultural sector transformation in the conditions of intensive penetration of digital technologies into the economy sector. The authors offer a schematic diagram of data collecting and processing in the start-to-finish automated production-and-marketing chain of activity within the agricultural secto

Interfacial adsorption and stripping of ions as a reason of stimuli responsive luminescence of Tb-doped silica nanoparticles

Herein we introduce the "on-off-on" switching of Tb-centered luminescence as a result of reversible adsorption of Fe III ions at the silica/water interface of Tb-doped silica nanoparticles and the stripping effect of anions. The interfacial adsorption of Fe III ions results in the charge neutralization and aggregation of Tb-doped silica nanoparticles, accompanied by significant quenching of Tb-centered luminescence. The analysis of the steady state and time resolved quenching measurements reveals both static and dynamic quenching mechanisms. The addition of EDTA and some phosphates, including ATP results in the deaggregation of nanoparticles due to the complex formation with Fe III ions and following stripping of FeIII ions from the silica surface. The "off-on" switching of Tb-centered luminescence resulted from the stripping effect of biorelevant phosphates is a good basis for further bioanalytical application. © 2011 Elsevier B.V. All rights reserved

CREATING A MATHEMATICAL MODEL OF A QUEUING SYSTEM SUPERMARKET

Today, the Russian retail market, there is a problem to optimize the use of existing resources. This problem is related to the saturation of the market due to the economic trend. One solution to this problem is to use mathematical models to optimize existing resources. This paper describes a mathematical model for the optimization of retail space supermarket

Estado psicoemocional dos alunos durante o período de autoisolamento pandêmico da COVID-19 no contexto dos fatores sociodemográficos

Psycho-emotional state of youth in the COVID-19 pandemic can become an indicator of various positive or negative social transformations and trends. The purpose of the study is to determine the influence of socio-demographic factors (gender, age, year of study, the direction of professional training at university, combining study and work, living in a rural area or a city, in a private house or an apartment, with parents or independently) in conditions of self-isolation on assessment of the main components of the psycho-emotional state of the students: well-being, activity, and mood. We used the method of rapid well-being, activity, and mood assessment. The test was conducted online; the relevant materials were posted on eCampus of North Caucasus Federal University educational portal. The research results analysis was based on Kruskal Wallice H-test, the primary frequency analysis, analysis of average scale values and standard deviations for the comparison groups. The study was conducted from April 13 to May 22, 2020, and involved 1,173 students aged 17 to 36 years, enrolled in 1-5 years. The study suggests that the psycho-emotional state of students in the self-isolation period depends on their age: the younger the students are, the more likely they are to experience fatigue and decline in well-being, activity, mood. The study provided new data on the features of integrated assessments of students’ well-being, activity, and mood in conditions of forced self-isolation due to the COVID-19 pandemic.El estado psicoemocional de los jóvenes en la pandemia de COVID-19 puede convertirse en un indicador de diversas transformaciones y tendencias sociales positivas o negativas. El propósito del estudio es determinar la influencia de factores sociodemográficos (género, edad, año de estudio, dirección de la formación profesional en la universidad, compaginación de estudio y trabajo, vivir en una zona rural o en una ciudad, en una casa particular). o un apartamento, con los padres o de forma independiente) en condiciones de autoaislamiento al evaluar los principales componentes del estado psicoemocional de los estudiantes: bienestar, actividad y estado de ánimo. Usamos el método de evaluación rápida del bienestar, la actividad y el estado de ánimo. La prueba se realizó en línea; los materiales pertinentes se publicaron en el portal educativo eCampus of North Caucasus Federal University. El análisis de los resultados de la investigación se basó en la prueba H de Kruskal Wallice, el análisis de frecuencia principal, el análisis de los valores de escala promedio y las desviaciones estándar para los grupos de comparación. El estudio se realizó del 13 de abril al 22 de mayo de 2020 e involucró a 1,173 estudiantes de 17 a 36 años, matriculados en 1-5 años. El estudio sugiere que el estado psicoemocional de los estudiantes en el período de autoaislamiento depende de su edad: cuanto más jóvenes son los estudiantes, es más probable que experimenten fatiga y deterioro del bienestar, la actividad y el estado de ánimo. El estudio proporcionó nuevos datos sobre las características de las evaluaciones integradas del bienestar, la actividad y el estado de ánimo de los estudiantes en condiciones de autoaislamiento forzado debido a la pandemia COVID-19.O estado psicoemocional dos jovens na pandemia COVID-19 pode se tornar um indicador de várias transformações e tendências sociais positivas ou negativas. O objetivo do estudo é verificar a influência de fatores sociodemográficos (sexo, idade, ano de estudo, direção da formação profissional na universidade, conciliar estudo e trabalho, residir em área rural ou na cidade, em residência particular ou um apartamento, com os pais ou independentemente) em condições de auto-isolamento na avaliação dos principais componentes do estado psicoemocional dos alunos: bem-estar, atividade e humor. Usamos o método de avaliação rápida de bem-estar, atividade e humor. O teste foi realizado online; os materiais relevantes foram postados no portal educacional eCampus da Universidade Federal do Norte do Cáucaso. A análise dos resultados da pesquisa foi baseada no teste H de Kruskal Wallice, análise de frequência primária, análise dos valores médios da escala e desvios-padrão para os grupos de comparação. O estudo foi realizado de 13 de abril a 22 de maio de 2020, e envolveu 1.173 alunos com idades entre 17 e 36 anos, matriculados em 1-5 anos. O estudo sugere que o estado psicoemocional dos alunos no período de auto-isolamento depende da idade: quanto mais jovens são os alunos, maior é a probabilidade de sofrerem de fadiga e declínio no bem-estar, atividade, humor. O estudo forneceu novos dados sobre as características das avaliações integradas do bem-estar, atividade e humor dos alunos em condições de auto-isolamento forçado devido à pandemia COVID-19.

Frequency of hemodynamic response to orthostatic stress in heart failure with reduced ejection fraction, associations with clinical blood pressure

Aim. To assess hemodynamic response to active standing test (AST) with beat-to-beat blood pressure (BP) monitoring, their association with office BP and symptoms of orthostatic intolerance in patients with heart failure (HF).Material and methods. Outpatient HF patients with documented  left ventricular ejection  fraction <40%, followed   up in a HF center  and receiving optimal medical therapy, underwent AST with beat-to-beat  non-invasive BP monitoring.Hemodynamic response was assessed according to the European Federation of Autonomic Societies criteria.Results. The study included 87 patients (mean age, 57±10 years; men, 76%). Normal hemodynamic response to orthostatic stress was observed  in 36 (41,4%) patients. Pathological response prevailed during the first minute of orthostatic stress — initial orthostatic hypotension (OH) (n=29, 33,3%) and delayed BP recovery (n=18, 20,7%).  Classical OH was detected  in 4 (4,6%)  patients. There was no orthostatic hypertension, defined as an increase in systolic BP (SBP) ≥20 mm Hg. According to office BP, hypotension was observed in 19 (21,8%) patients (SBP <90 mm Hg in 4 patients and 90-100 mm Hg in 15), hypertension (SBP >140 mm Hg) in 11 (12,6%) patients. Pathological response to orthostatic stress were more often observed  in office  SBP >140 mm Hg compared  to SBP ≤140 mmHg (90,9% and 53,9%, p=0,020).Orthostatic intolerance was noted in 43 (49,4%) patients and were not associated with the level of office SBP (p=0,398) or pathological responses to orthostatic stress (p=0,758 for initial OH and p=0,248  for delayed  BP recovery).Conclusion. The pathological hemodynamic response in AST with beat-to-beat BP monitoring in ambulatory patients with HF is most often represented  by initial OH and delayed BP recovery associated  with office SBP >140 mmHg. The frequency of symptoms of orthostatic intolerance did not differ between groups depending on the presence of an inadequate response to orthostatic stress

Features of cellular structure of the induced sputum and profile of cytokines at sintropiya of bronchial asthma and obesity at young patients

Aim. To estimate changes of cellular structure of the induced sputum at young patients with bronchial asthma at interrelations with BMI and level of cytokines in blood plasma. Materials and methods. 164 patients with bronchial asthma were divided into 2 groups taking into BMI: the 1st group included patients with bronchial asthma and BMI from 18 to 25 kg/m2, patients with bronchial asthma and BMI from 30 to 40 kg/m2 entered into the 2nd group. The group of control was made by 40 almost healthy volunteers. Estimated existence of excess weight and defined obesity degree according to recommendations of World Health Organization. Studied the level of control of bronchial asthma, cellular structure of the induced sputum, the IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-15, IL-17, TNF-α, INF-γ levels in plasma of peripheral blood. Results. There are presented the results of the research of cellular profile of the induced sputum and profile of cytokines at patients with bronchial asthma depending on BMI and severity of the disease. The received results testify to prevalence of eosinophilic type of an inflammation in the group of patients with BMI less than 25 kg/m2 whereas at patients mainly paucigranulation inflammation decided on obesity. The highest content of the Il-17 was registered at patients with bronchial asthma and obesity as in comparison with indicators of patients with normal BMI, and with almost healthy that, perhaps, is the reason of low effect of steroid therapy at these patients. Conclusion. Endotype assessment before basic antiinflammatory therapy at patients with the first time diagnosed bronchial asthma, will be able to help with selection of the most optimum treatment to each specific patient

ICD-10 code-based definition of heart failure in Saint Petersburg electronic health records: prevalence, health care utilization and outcomes

Aim. To analyze prevalence of heart failure (HF), clinical and demographic characteristics, health care utilization, and outcomes according to the used International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) codes in regional integrated electronic health record database in Saint Petersburg.Material and methods. The retrospective analysis of the Saint Petersburg regional integrated electronic health record database for 2019 was performed. At least one of the following ICD-10 codes has been considered as HF case: I50.x (standard coding) and/or I11.0, I13.0, I13.2, I25.5, I42.0, I42.9, I09.9, I43.0, I43.1, I43.2, I43.8, I42.5, I42.6, I42.7, I42.8 (extended coding).Results. A total of 64070 adult patients with HF had medical encounters in 2019, 34,5% of whom were identified using standard coding, 65,5% — using extended coding. The combination of codes was observed in 9,9% of cases. HF prevalence/mortality was 1,4%/6,8% in general, as well as 0,49%/15,7% and 0,93%/2,1% with standard and extended coding, respectively. HF patients had high healthcare utilization with the mean number of 14 encounters per patient per year. Actually, 24% of patients had more than 20 both inpatient and outpatient encounters and 54% of patients — at least 1 all-cause hospitalization during the year. Encounters of patients with HF accounted for 4,3% of all visits, 6,5% of all hospitalizations, 4,1% of all outpatient visits and 9,7% of all emergency contacts during the year. Patients identified by the standard coding compared with the extended coding had older age and higher incidence of comorbidities, as well as greater hospitalization and death rates, but lower number of outpatient visits.Conclusion. The prevalence of HF among the adult population of Saint. Petersburg in 2019 was 1,4%. HF was characterized by a high health care utilization and mortality rate reaching 15,7 % per year. The use of different approaches to coding presumably could help to identify different groups of patients with HF, which requires the adaptation of healthcare models and an active monitoring system to reduce the risk of adverse events