Inter-core crosstalk in weakly coupled MCFs with arbitrary core layout and the effect of bending and twisting on the coupling coefficient

We investigate the bending and twisting-induced longitudinal variation of the inter-core coupling coefficient (ICCC) and its effect on inter-core crosstalk (ICXT) in weakly coupled multi-core fibers (MCFs) with an arbitrary core layout. An analytical discrete changes model (DCM) for ICXT field propagation under those conditions is proposed for the first time, providing very fast and rather accurate mean ICXT power estimates. The analytical mean ICXT power estimates are validated through numerical simulation. It is predicted that the mean ICXT power between adjacent cores of the outer ring of the 19-core MCF can be more than 10 dB higher than the one between adjacent cores of the inner ring. It is also predicted that the difference between the mean ICXT power of cores in the inner and outer rings can be much smaller by decreasing the core pitch and increasing the bending radius. This behavior is attributed to the ICXT dependence on the bending and twisting-induced longitudinal variation of the ICCCs. In particular, larger bending and twisting-induced fluctuations of the ICCCs along the longitudinal coordinate are observed in the cores of the outer ring, but the fluctuations become smaller for smaller core pitches and larger bending radii. Furthermore, it is shown that, if the ICCCs’ longitudinal variation is neglected, the mean ICXT power estimates between two adjacent cores are very similar despite the location of those cores. This means that neglecting the longitudinal variation of the ICCCs can lead to misleading estimates of the mean ICXT power, with an error exceeding 15 dB.info:eu-repo/semantics/publishedVersio

Dual polarization discrete changes model of inter-core crosstalk in multi-core fibers

The discrete changes model (DCM) of inter-core crosstalk (ICXT) in weakly-coupled homogeneous multi-core fibers (MCFs) is generalized to a dual polarization (DP) scheme. This model provides theoretical expressions for the two polarization fields of the ICXT at the MCF output. Therefore, it may be of particular interest in the design of direct-detection MCF systems, where the photodetected ICXT results mainly from the beating between the ICXT field at the MCF output and the carrier of the interfered core. The DP-DCM is validated by comparison of the mean ICXT power and ICXT field amplitude estimates with the ones obtained with a rigorous, yet much more computationally demanding, model based on the coupled local mode theory (CLMT). Good agreement between the mean ICXT power estimates obtained with the DP-DCM and CLMT is observed when the inter-core coupling coefficient variation along the MCF is small. Good agreement is also observed when comparing the probability density functions of the ICXT field amplitude

Glomerular filtration rate change during chronic hepatitis C treatment with Sofosbuvir/Ledipasvir in HCV/HIV Coinfected patients treated with Tenofovir and a boosted protease inhibitor: an observational prospective study

INTRODUCTION: Concomitant use of ledipasvir and boosted protease inhibitors (PIs) may increase the risk of tenofovir (TDF) nephrotoxicity, since both these drugs increase TDF levels. Our aim was to evaluate glomerular filtration rate (eGFR) evolution during HCV treatment with sofosbuvir/ledipasvir (SOF/LDV) in HCV/HIV coinfected patients, according to their antiretroviral treatment (ARV). METHODS: Observational prospective study of HCV/HIV coinfected patients treated with SOF/LDV. eGFR evolution was evaluated during and 12 weeks after HCV treatment. Patients were categorized in three groups based on ARV regimen: non TDF, non-boosted TDF and TDF + boosted PI. RESULTS: We included 273 patients: 145 were receiving a non-TDF regimen, 78 a non-boosted TDF scheme and 50 were receiving TDF + boosted PI. We observed a statistically significant decrease in eGFR during treatment in all groups (non TDF p = 0.03, 95%CI [0.23-3.86], non-boosted TDF p < 0.01, 95%CI [3.36-7.44], TDF + PI p = 0.01, 95%CI [1.09-7.53]). The decrease was more pronounced in those receiving unboosted TDF (- 5.40 ml/min/1.73m2), but differences in eGFR decrease between the three groups were small and not statistically different (p = 0.06). eGFR decrease was greater in patients treated for 24 weeks (p = 0.009) and in cirrhotic patients (p = 0.036). At the end of follow up a recovery of eGFR was observed in all groups. CONCLUSION: We observed a significant decrease in eGFR during treatment in all study groups, that was small and reversible after SOF/LDV discontinuation. TDF was not associated with an increase in renal toxicity.info:eu-repo/semantics/publishedVersio

Genetic predisposition for aggressive behaviour related with dopamine and serotonin pathways : an overview

Abstract in proceedings of the Fourth International Congress of CiiEM: Health, Well-Being and Ageing in the 21st Century, held at Egas Moniz’ University Campus in Monte de Caparica, Almada, from 3–5 June 2019.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.info:eu-repo/semantics/publishedVersio

Juventude, precariedade e desigualdades: as classes contra o fim da história

Com o impacto da crise financeira, foram expostas as fragilidades a que os poderes públicos têm exposto o “modelo social europeu”. Com o aumento do desemprego de longa duração e da precariedade do trabalho, os jovens parecem estar cada vez mais expostos à pobreza, à exclusão social e engrossam cada vez mais a categoria dos “novos pobres”. A generalização da precariedade e da pobreza, a complexificação da estrutura de classes como mecanismo estruturador das desigualdades e as transformações profundas no mundo do trabalho convocam o debate sociológico, colocando novas perguntas para pensar uma realidade social em transformação acelerada. Neste contexto, a partir de dados estatísticos do continente europeu e tomando a precariedade e os jovens como objecto central, este artigo procura reflectir sobre os impactos das transformações no mundo do trabalho e da reconfiguração das estruturas de classes na proliferação de “novas” formas de pobreza na Europa

Saccharomyces cerevisiae as a toxicological model to study synthetic cannabinoids and its pyrolysis products

Poster presented at the 7th European Academy of Forensic Science Conference. Prague, 6-11 September 2015"Synthetic cannabinoids are among the major psychoactive drugs widespread as safe and legal alternatives to cannabis. They are commercially available as herbal incense products intended for smoke. This has led most of developed countries to concentrate efforts in order to ban the so called “legal highs”. Despite of their increasing use, there is still a lack of information on both synthetic and natural ingredients, pharmacokinetic properties and toxic effects. In fact some of the substances seem to have stronger toxicological effects when compared to their legal counterpart. Toxicological assays are paramount to know how harmful these new substances are, helping increase public awareness since several hospitalization cases have been reported due to consumption. To tackle the new challenges posed by novel drugs worldwide, we developed an approach using Saccharomyces cerevisiae as a model to investigate the toxicity of pyrolysis products of synthetic cannabinoids. S. cerevisiae.

Demographic, etiological, and histological pulmonary analysis of patients with acute respiratory failure: a study of 19 years of autopsies

INTRODUCTION: Acute respiratory failure has been one of the most important causes of death in intensive care units, and certain aspects of its pulmonary pathology are currently unknown. OBJECTIVES: The objective was to describe the demographic data, etiology, and pulmonary histopathological findings of different diseases in the autopsies of patients with acute respiratory failure. METHOD: Autopsies of 4,710 patients with acute respiratory failure from 1990 to 2008 were reviewed, and the following data were obtained: age, sex, and major associated diseases. The pulmonary histopathology was categorized as diffuse alveolar damage, pulmonary edema, alveolar hemorrhage, and lymphoplasmacytic interstitial pneumonia. The odds ratio of the concordance between the major associated diseases and specific autopsy findings was calculated using logistic regression. RESULTS: Bacterial bronchopneumonia was present in 33.9% of the cases and cancer in 28.1%. The pulmonary histopathology showed diffuse alveolar damage in 40.7% (1,917) of the cases. A multivariate analysis showed a significant and powerful association between diffuse alveolar damage and bronchopneumonia, HIV/AIDS, sepsis, and septic shock, between liver cirrhosis and pulmonary embolism, between pulmonary edema and acute myocardial infarction, between dilated cardiomyopathy and cancer, between alveolar hemorrhage and bronchopneumonia and pulmonary embolism, and between lymphoplasmacytic interstitial pneumonia and HIV/ AIDS and liver cirrhosis. CONCLUSIONS: Bronchopneumonia was the most common diagnosis in these cases. The most prevalent pulmonary histopathological pattern was diffuse alveolar damage, which was associated with different inflammatory conditions. Further studies are necessary to elucidate the complete pathophysiological mechanisms involved with each disease and the development of acute respiratory failure

Phosphorus supply for the establishment of palisade grass and forage peanut grown in association.

Fósforo (P) é um nutriente-chave para o estabelecimento de consórcio de gramíneas e leguminosas forrageiras. O objetivo deste trabalho foi determinar a necessidade de P para o estabelecimento de capim-braquiarão e amendoim forrageiro cultivados em associação sob condições controladas. Um experimento de vasos foi conduzido em casa de vegetação usando o delineamento em blocos completos ao acaso com oito tratamentos e quatro repetições. Os tratamentos foram as seguintes doses de P: 0 mg dm-3 (controle), 80 mg dm-3, 160 mg dm-3, 240 mg dm-3, 320 mg dm-3, 400 mg dm-3 e 560 mg dm-3 [fonte: Ca(H2PO4)2.H2O]. Capim-braquiarão (Urochloa brizantha 'Marandu') e amendoim forrageiro (Arachis pintoi 'BRS Mandobi') foram cultivados por 24 dias depois do corte de uniformização e então cortados a 10 cm de altura para determinação da matéria seca do topo da planta. O suprimento adequado de P para o crescimento do topo da planta diferiu entre as espécies. Capim-braquiarão necessitou de 80 mg dm-3 de P, ao passo que 160 mg dm-3 de P foram exigidos pelo amendoim forrageiro. O amendoim forrageiro necessitou de mais P do que o capim-braquiarão para o estabelecimento de ambas as espécies cultivadas em associação sob condições controladas

Combination with tomatidine improves the potency of posaconazole against Trypanosoma cruzi

Azoles such as posaconazole (Posa) are highly potent against Trypanosoma cruzi. However, when tested in chronic Chagas disease patients, a high rate of relapse after Posa treatment was observed. It appears that inhibition of T. cruzi cytochrome CYP51, the target of azoles, does not deliver sterile cure in monotherapy. Looking for suitable combination partners of azoles, we have selected a set of inhibitors of sterol and sphingolipid biosynthetic enzymes. A small-scale phenotypic screening was conducted in vitro against the proliferative forms of T. cruzi, extracellular epimastigotes and intracellular amastigotes. Against the intracellular, clinically relevant forms, four out of 15 tested compounds presented higher or equal activity as benznidazole (Bz), with EC50 values </=2.2 muM. Ro48-8071, an inhibitor of lanosterol synthase (ERG7), and the steroidal alkaloid tomatidine (TH), an inhibitor of C-24 sterol methyltransferase (ERG6), exhibited the highest potency and selectivity indices (SI = 12 and 115, respectively). Both were directed to combinatory assays using fixed-ratio protocols with Posa, Bz, and fexinidazole. The combination of TH with Posa displayed a synergistic profile against amastigotes, with a mean SigmaFICI value of 0.2. In vivo assays using an acute mouse model of T. cruzi infection demonstrated lack of antiparasitic activity of TH alone in doses ranging from 0.5 to 5 mg/kg. As observed in vitro, the best combo proportion in vivo was the ratio 3 TH:1 Posa. The combination of Posa at 1.25 mpk plus TH at 3.75 mpk displayed suppression of peak parasitemia of 80% and a survival rate of 60% in the acute infection model, as compared to 20% survival for Posa at 1.25 mpk alone and 40% for Posa at 10 mpk alone. These initial results indicate a potential for the combination of posaconazole with tomatidine against T. cruzi