A Novel Tetraoxygenated Δ8(9),15-Pimaric Acid Methyl Ester From Lycopus Europaeus - II

Identification of a novel diterpene (la-hydroxy-7a,l1a,14~-triacetoxy-LB(gJ.15_pimaraicid methyl ester) from plant species Lycopus Europaeus by means of two-dimensional IH homonuclear correlated NMR spectroscopy (COSY) is reported

Half a century of spectroscopy on Studentski trg (Belgrade)

Gallery of Science and Technology SASA ; no 2

The reasons for development of complications in soft contact lenses wearers: A qualitative study

© 2020, Serbian Medical Society. All rights reserved. Objective. To determine reasons and their actual role in occurrence of complications in users of soft contact lenses. Methods. This was a qualitative study in which a constructivist grounded theory approach was used to analyze obtained data. The study population consisted of two groups of subjects: 10 students who were identified as users of soft contact lenses and 4 ophthalmologists. Each of the respondents participated ina single interview. Based on audio recordings of these interviews appropriate transcripts of conversations were made and analyzed. After elimination of waste words 11 key categories were crystallized. Results. Recommendations of the ophthalmologists perhaps have the decisive role in the formation of attitude that users will have regarding the adequate hygiene of soft contact lenses: hand hygiene, proper cleanliness of storage for soft contact lenses and using the solution in the allotted time are imperative for users of soft contact lenses. Sleeping with soft contact lenses for a long period and more frequently than it was specified in the recommendation of an ophthalmologist is one of the greatest reasons for development of dry eye symptoms, while swimming with soft contact lenses increases the risk for occurrence of eye infections. Conclusion. The main reasons for the occurrence of complications in soft contact lenses users are inadequate hygiene and weakening of compliance of soft contact lenses users over time

Artemisinin Story from the Balkans

The isolation is reported of artemisinin (qinghaosu), a drug remarkably effective against malaria, from the aerial parts of Artemisia annua L. (sweet wormwood) at the Department of Chemistry, University of Belgrade (now Faculty of Chemistry), Serbia by the end of 1970, almost two years before the isolation of the same compound in China

Sekundarni metaboliti biljne vrste Hypericum monogynum iz Pakistana

4-Chlorobenzoic acid (1), quercitrin (2), astilbin (3), along with beta-sitosterol, gamma-sitosterol, friedelin and beta-amyrin were isolated from the aerial parts of Hypericum monogynum. Whereas compound 1 was isolated for the first time from natural sources, flavanonol 3 was not found before in these species.4-Hlorobenzoeva kiselina (1), kvercitrin (2), astilbin (3), kao i β-sitosterol, γ- sitosterol, fridelin i β-amirin izolovani su iz nadzemnih delova biljne vrste Hypericum monogynum. Po prvi put jedinjenje 1 je izolovano iz prirodnih izvora, dok flavanonol 3 do sada nije izolovan iz ove biljne vrste

New insights into sesquiterpene lactones composition of Western Balkan’s genus Amphoricarpos revealed by rapid resolution liquid chromatography coupled with quadrupole time-of-flight mass spectrometry

This study revealed results from reinvestigation of sesquiterpene lactones composition in the crude and leaf surface extracts of Amphoricarpos plants by rapid resolution liquid chromatography (RRLC) coupled with quadrupole time-of-flight mass spectrometry (QToF MS) and the tentative identification of undescribed sesquiterpene lactones is presented.11th Conference on Medicinal and Aromatic Plants of Southeast European Countries, (11th CMAPSEEC), Ohrid, North Macedonia, 6–10 October 202

Hemijski sastav ekstrakta semenki bele ribizle

From the seeds of white currant (Ribes rubrum, cv. White Champagne), a new sesquiterpenoid glycoside 1 was isolated, along with two known compounds: dihydrophaseic acid 3'-O-beta-D-glucopyranoside (2), and 3-carboxymethyl-indole-1-N-beta-D-glucopyranoside (3). The structure of the new compound was identified as dihydrophaseic acid 3'-O-beta-gentiobioside, based on extensive NMR and MS spectral studies.Iz semena bele ribizle (Ribes rubrum, cv. bela šampanjska) izolovan je novi seskviterpenski glukozid (1), zajedno sa dva poznata jedinjenja: 3'-O-b-D-glukopiranozidom dihidrofazeinske kiseline (2) i 3-karboksimetilindol-1-N-b-D-glukopiranozidom (3). Na osnovu detaljnih NMR i MS studija, struktura novog jedinjenja je određena kao 3'-O-b-genciobiozid dihidrofazeinske kiseline

Anti-melanoma effects of ingenanes isolated from Euphorbia species

In this research, from two species, E. palustris and E. lucida, four ingenane derivatives were isolated. Their anticancer effects were evaluated in the human melanoma – 518A2 cell line and compared with the effects of ingenolmebutate. Selectivity towards human melanoma cells was determined using normal human keratinocytes – HaCaT.11th Conference on Medicinal and Aromatic Plants of Southeast European Countries, (11th CMAPSEEC), Ohrid, North Macedonia, 6–10 October 202

Koncentracija trans- i cis-rezveratrola u vinima proizvedenim u Srbiji

Resveratrol, which occurs in two isomeric forms, trans and cis, is a phytoalexin with numerous pharmacological activities, such as anti-cancer, antiviral, neuroprotective and anti-aging. Red wine is the main source of the compound and an easy way of including resveratrol in the human diet. In this study, the most popular commercial Serbian wines (red, white and rose-type) were analyzed for their content of trans- and cis-resveratrol. The analysis was performed by HPLC with a UV detector. Prior to the injection, phenolic compounds were extracted onto a LiChrolut RP18 bonded silica cartridge. The concentration of trans-resveratrol ranged from 0.11 to 1.69 mg L-1 and cis-resveratrol from 0.12 to 1.49 mg L-1.Metodom tečne hromatografije (HPLC) ispitan je sadržaj slobodnog oblika trans- i cis-rezveratrola u osamnaest komercijalnih uzoraka (10 crvenih, 7 belih i 1 roze) srpskih vina. Svi uzorci su pre hromatografije ekstrahovani SPE tehnikom na LiChrolut RP18 koloni. trans-Rezveratrol je detektovan u 17 od 18 analiziranih uzoraka vina sa prosečnom koncentracijama od 0,78 mg l-1 za crvena vina i 0,23 mg l-1 za bela vina. Najviša koncentracija trans-rezveratrola je nađena u uzorku crvenog vina Cabernet Sauvignon berbe 2002 godine. cis-Rezveratrol je detektovan u 12 od 18 analiziranih uzoraka vina sa prosečnom koncentracijom 0,55 mg l-1 za crvena vina, dok je u belim vinima od analiziranih 7 uzoraka detektovan samo u 2 uzorka sa koncentracijama 0,12 i 0,49 mg l-1. Visok sadržaj cis-rezveratrola u nekim uzorcima je verovatno posledica izomerizacije trans- u cis-rezveratrol tokom procesa proizvodnje vina

Costs of treating type 2 diabetes mellitus and its complications

The major driver of the costs of treating patients with diabetes mellitus type 2 (DM2) is its complications, which in developing countries are a consequence of poor glycemic control due to the low availability of novel, innovative antidiabetic drugs. We aimed to determine the ratio of direct medical costs arising from DM2 to the direct costs of its complications, as well as their main predictors. This was a retrospective cohort study of health care utilization and direct medical costs for adults with DM2, with (inpatients) or without (outpatients) complications. The utilization data were multiplied by the unit prices of drugs and services reimbursed by the Serbian Republic Health Insurance Fund to obtain direct costs. In total, 205 inpatients and 60 outpatients with DM2 participated in the study. Key drivers of the costs of treating diabetes complications in hospitals are consultations with specialist clinicians (B = 0.025 [0.003–0.047]), use of reserve antibiotics (B = 0.022 [0.007–0.036]), biochemical tests (B = 0.038 [0.022–0.055]) and length of stay in the hospital (B = 0.011 [0.009–0.013]). On the other hand, the number of encounters with general practitioners (B = 0.179 0.115–0.242) and the number of ultrasound examinations are strongly correlated with the total costs of treating outpatients with DM2 (B = 0.234 [0.054–0.414]). None of the outpatients included in the study were prescribed novel antidiabetic drugs. Overall, the costs of treating DM2 in Serbia are considerable and mainly driven by the 2–11-fold higher costs of complications vs. the costs of the disease itself