CFHTLenS: Weak lensing constraints on the ellipticity of galaxy-scale matter haloes and the galaxy-halo misalignment

We present weak lensing constraints on the ellipticity of galaxy-scale matter haloes and the galaxy-halo misalignment. Using data from the Canada-France-Hawaii Telescope Lensing Survey (CFHTLenS), we measure the weighted-average ratio of the aligned projected ellipticity components of galaxy matter haloes and their embedded galaxies, $f_\mathrm{h}$, split by galaxy type. We then compare our observations to measurements taken from the Millennium Simulation, assuming different models of galaxy-halo misalignment. Using the Millennium Simulation we verify that the statistical estimator used removes contamination from cosmic shear. We also detect an additional signal in the simulation, which we interpret as the impact of intrinsic shape-shear alignments between the lenses and their large-scale structure environment. These alignments are likely to have caused some of the previous observational constraints on $f_\mathrm{h}$ to be biased high. From CFHTLenS we find $f_\mathrm{h}=-0.04 \pm 0.25$ for early-type galaxies, which is consistent with current models for the galaxy-halo misalignment predicting $f_\mathrm{h}\simeq 0.20$. For late-type galaxies we measure $f_\mathrm{h}=0.69_{-0.36}^{+0.37}$ from CFHTLenS. This can be compared to the simulated results which yield $f_\mathrm{h}\simeq 0.02$ for misaligned late-type models.Comment: 21 pages, 3 tables, 9 figures. This replacement matches the version accepted for publication in MNRA

Адаптируемая фитоустановка как инструмент формирования экологической ответственности

В работе анализируется проблема низкой экологической культуры городского населения и выдвигается гипотеза ее решения. Цель работы – создание функционального, эргономичного и эстетичного дизайн-объекта, способствующего формированию экологической ответственности пользователей. Объектом исследования является потенциал дизайна в организации процесса обучения. В результате исследования разработан дизайн-проект адаптируемой установки для выращивания растений. Область применения: спроектированная установка предназначена для коллективного пользования сотрудников офисов и коворкингов.The paper analyzes the problem of low ecological culture of the urban population and puts forward a hypothesis for its solution. The purpose of the work is to create a functional, ergonomic and aesthetic design object that contributes to the formation of ecological responsibility of users. The object of research is the potential of design in the organization of the learning process. As a result of the research, a design project of an adaptable installation for growing plant is being developed. Scope: the designed installation is intended for collective use by employees of offices and coworkings

Remote sensing of vegetation fires and its contribution to a fire management information system

In the last decade, research has proven that remote sensing can provide very useful support to fire managers. This chapter provides an overview of the type of information remote sensing can provide to the fire community. It considers first fire management information needs in the context of fire management information system. An introduction to remote sensing then precedes the description of fire information obtainable from remote sensing data (such as vegetation status, active fire detection and burned areas assessment). Finally, operational examples in five African countries illustrate how the information can be used in practice

Selenium isotope evidence for progressive oxidation of the Neoproterozoic biosphere

This study was funded by NERC grant NE/F016832/1. P.A.E.P.v.S. is supported by NERC fellowship NE/I020571/2.Neoproterozoic (1,000–542 Myr ago) Earth experienced profound environmental change, including ‘snowball’ glaciations, oxygenation and the appearance of animals. However, an integrated understanding of these events remains elusive, partly because proxies that track subtle oceanic or atmospheric redox trends are lacking. Here we utilize selenium (Se) isotopes as a tracer of Earth redox conditions. We find temporal trends towards lower δ82/76Se values in shales before and after all Neoproterozoic glaciations, which we interpret as incomplete reduction of Se oxyanions. Trends suggest that deep-ocean Se oxyanion concentrations increased because of progressive atmospheric and deep-ocean oxidation. Immediately after the Marinoan glaciation, higher δ82/76Se values superpose the general decline. This may indicate less oxic conditions with lower availability of oxyanions or increased bioproductivity along continental margins that captured heavy seawater δ82/76Se into buried organics. Overall, increased ocean oxidation and atmospheric O2 extended over at least 100 million years, setting the stage for early animal evolution.Publisher PDFPeer reviewe

Desmopressin for reversal of Antiplatelet drugs in Stroke due to Haemorrhage (DASH): protocol for a phase II double-blind randomised controlled feasibility trial

IntroductionIntracerebral haemorrhage can be devastating and is a common cause of death and disability worldwide. Pre-intracerebral haemorrhage antiplatelet drug use is associated with a 27% relative increase in one-month case fatality compared to patients not using antithrombotic drugs. We aim to assess the feasibility of conducting a randomised controlled testing the safety and efficacy of desmopressin for patients with antiplatelet-associated intracerebral haemorrhage.Methods and AnalysisWe aim to include 50 patients within 24 hours of spontaneous intracerebral haemorrhage onset, associated with oral antiplatelet drug(s) use in at least the preceding seven days. Patients will be randomised (1:1) to receive intravenous desmopressin 20μg in 50 mls sodium chloride 0.9% infused over 20 minutes or matching placebo. We will mask participants, relatives and outcome assessors to treatment allocation. Feasibility outcomes include proportion of patients approached being randomised, number of patients receiving allocated treatment, rate of recruitment, and adherence to treatment and follow up. Secondary outcomes include change in intracerebral haemorrhage volume at 24 hours; hyponatraemia at 24 hours, length of hospital stay, discharge destination, early death less than 28 days, death or dependency at day 90, death up to day 90, serious adverse events (including thromboembolic events) up to day 90; disability (Barthel index, day 90), quality of life (EuroQol 5D (EQ-5D], day 90), cognition (telephone mini-mental state examination day 90), and health economic assessment (EQ-5D).Ethics and disseminationThe DASH trial received ethical approval from the East Midlands - Nottingham 2 research ethics committee (18/EM/0184). The DASH trial is funded by NIHR RfPB grant: PB-PG-0816-20011. Trial results will be published in a peer reviewed academic journal and disseminated through academic conferences and through patient stroke support groups. Reporting will be in compliance with CONSORT recommendations

Validating a forced‑choice method for eliciting quality‑of‑reasoning judgments

In this paper we investigate the criterion validity of forced-choice comparisons of the quality of written arguments with normative solutions. Across two studies, novices and experts assessing quality of reasoning through a forced-choice design were both able to choose arguments supporting more accurate solutions—62.2% (SE = 1%) of the time for novices and 74.4% (SE = 1%) for experts—and arguments produced by larger teams—up to 82% of the time for novices and 85% for experts—with high inter-rater reliability, namely 70.58% (95% CI = 1.18) agreement for novices and 80.98% (95% CI = 2.26) for experts. We also explored two methods for increasing efficiency. We found that the number of comparative judgments needed could be substantially reduced with little accuracy loss by leveraging transitivity and producing quality-of-reasoning assessments using an AVL tree method. Moreover, a regression model trained to predict scores based on automatically derived linguistic features of participants’ judgments achieved a high correlation with the objective accuracy scores of the arguments in our dataset. Despite the inherent subjectivity involved in evaluating differing quality of reasoning, the forced-choice paradigm allows even novice raters to perform beyond chance and can provide a valid, reliable, and efficient method for producing quality-of-reasoning assessments at scale

Sustainable Diets: another hurdle or a better food future?,

The notion of sustainable diets has emerged forcibly onto the food policy agenda in recent years, but has also met resistance. The article reviews the case for sustainable diets. It counterbalances the current dominant policy emphasis on raising food output as the best route to a sustainable food future. The article suggests that a process of democratic experimentation is underway. Some official guidelines have emerged alongside a mix of civil society and academic formulations. More coherence of data, principles and purpose is needed at the global and regional policy-making levels for these to become effective in the common task of reducing the food system’s negative impact on health, environment and economies

Image-based consensus molecular subtyping in rectal cancer biopsies and response to neoadjuvant chemoradiotherapy

The development of deep learning (DL) models to predict the consensus molecular subtypes (CMS) from histopathology images (imCMS) is a promising and cost-effective strategy to support patient stratification. Here, we investigate whether imCMS calls generated from whole slide histopathology images (WSIs) of rectal cancer (RC) pre-treatment biopsies are associated with pathological complete response (pCR) to neoadjuvant long course chemoradiotherapy (LCRT) with single agent fluoropyrimidine. DL models were trained to classify WSIs of colorectal cancers stained with hematoxylin and eosin into one of the four CMS classes using a multi-centric dataset of resection and biopsy specimens (n = 1057 WSIs) with paired transcriptional data. Classifiers were tested on a held out RC biopsy cohort (ARISTOTLE) and correlated with pCR to LCRT in an independent dataset merging two RC cohorts (ARISTOTLE, n = 114 and SALZBURG, n = 55 patients). DL models predicted CMS with high classification performance in multiple comparative analyses. In the independent cohorts (ARISTOTLE, SALZBURG), cases with WSIs classified as imCMS1 had a significantly higher likelihood of achieving pCR (OR = 2.69, 95% CI 1.01–7.17, p = 0.048). Conversely, imCMS4 was associated with lack of pCR (OR = 0.25, 95% CI 0.07–0.88, p = 0.031). Classification maps demonstrated pathologist-interpretable associations with high stromal content in imCMS4 cases, associated with poor outcome. No significant association was found in imCMS2 or imCMS3. imCMS classification of pre-treatment biopsies is a fast and inexpensive solution to identify patient groups that could benefit from neoadjuvant LCRT. The significant associations between imCMS1/imCMS4 with pCR suggest the existence of predictive morphological features that could enhance standard pathological assessment

8. Remote Sensing Of Vegetation Fires And Its Contribution To A Fire Management Information System

In the last decade, research has proven that remote sensing can provide very useful support to fire managers. This chapter provides an overview of the types of information remote sensing can provide to the fire community. First, it considers fire management information needs in the context of a fire management information system. An introduction to remote sensing then precedes a description of fire information obtainable from remote sensing data (such as vegetation status, active fire detection and burned areas assessment). Finally, operational examples in five African countries illustrate the practical use of remotely sensed fire information. As indicated in previous chapters, fire management usually comprises activities designed to control the frequency, area, intensity or impact of fire. These activities are undertaken in different institutional, economic, social, environmental and geographical contexts, as well as at different scales, from local to national. The range of fire management activities also varies considerably according to the management issues at stake, as well as the available means and capacity to act. Whatever the level, effective fire management requires reliable information upon which to base appropriate decisions and actions. Information will be required at many different stages of this fire management system. To illustrate this, we consider a typical and generic description of a fire management loop , as provided in Figure 8.1. Fire management objectives result from fire related knowledge . For example, they may relate to sound ecological reasons for prescribed burning in a particular land management context, or to frequent, uncontrolled fires threatening valuable natural or human resources. Whatever the issues, appropriate objectives require scientific knowledge (such as fire impact on ecosystems components, such as soil and vegetation), as well as up-to date monitoring information (such as vegetation status, fire locations, land use, socioeconomic context, etc.). Policies, generally at a national and governmental level, provide the official or legal long term framework (e.g. five to ten years) to undertake actions. A proper documentation of different fire issues, and their evolution, will allow their integration into appropriate policies, whether specific to fire management, or complementary to other policies in areas such as forestry, rangeland, biodiversity, land tenure, etc. Strategies are found at all levels of fire management. They provide a shorter-term framework (e.g. one to five years) to prioritise fire management activities. They involve the development of a clear set of objectives and a clear set of activities to achieve these objectives. They may also include research and training inputs required, in order to build capacity and to answer specific questions needed to improve fire management. The chosen strategy will result from a trade-off between priority fire management objectives and the available capacity to act (e.g. institutional framework, budget, staff, etc.), and will lead towards a better allocation of resources for fire management operations to achieve specific objectives. One example in achieving an objective of conserving biotic diversity may be the implementation of a patch-mosaic burning system (Brockett et al., 200 1 ) instead of a prescribed block burning system, based on an assumption that the former should better promote biodiversity in the long-term than the latter (Parr & Brockett, 1999). This strategy requires the implementation of early season fires to reduce the size of later season fires. The knowledge of population movements, new settlements or a coming El Nino season, should help focus the resources usage, as these factors might influence the proportion as well as the locations of area burned. Another strategy may be to prioritise the grading of fire lines earlier than usual based on information on high biomass accumulation. However, whatever the strategies, they need to be based on reliable information

8. Remote Sensing Of Vegetation Fires And Its Contribution To A Fire Management Information System

In the last decade, research has proven that remote sensing can provide very useful support to fire managers. This chapter provides an overview of the types of information remote sensing can provide to the fire community. First, it considers fire management information needs in the context of a fire management information system. An introduction to remote sensing then precedes a description of fire information obtainable from remote sensing data (such as vegetation status, active fire detection and burned areas assessment). Finally, operational examples in five African countries illustrate the practical use of remotely sensed fire information. As indicated in previous chapters, fire management usually comprises activities designed to control the frequency, area, intensity or impact of fire. These activities are undertaken in different institutional, economic, social, environmental and geographical contexts, as well as at different scales, from local to national. The range of fire management activities also varies considerably according to the management issues at stake, as well as the available means and capacity to act. Whatever the level, effective fire management requires reliable information upon which to base appropriate decisions and actions. Information will be required at many different stages of this fire management system. To illustrate this, we consider a typical and generic description of a fire management loop , as provided in Figure 8.1. Fire management objectives result from fire related knowledge . For example, they may relate to sound ecological reasons for prescribed burning in a particular land management context, or to frequent, uncontrolled fires threatening valuable natural or human resources. Whatever the issues, appropriate objectives require scientific knowledge (such as fire impact on ecosystems components, such as soil and vegetation), as well as up-to date monitoring information (such as vegetation status, fire locations, land use, socioeconomic context, etc.). Policies, generally at a national and governmental level, provide the official or legal long term framework (e.g. five to ten years) to undertake actions. A proper documentation of different fire issues, and their evolution, will allow their integration into appropriate policies, whether specific to fire management, or complementary to other policies in areas such as forestry, rangeland, biodiversity, land tenure, etc. Strategies are found at all levels of fire management. They provide a shorter-term framework (e.g. one to five years) to prioritise fire management activities. They involve the development of a clear set of objectives and a clear set of activities to achieve these objectives. They may also include research and training inputs required, in order to build capacity and to answer specific questions needed to improve fire management. The chosen strategy will result from a trade-off between priority fire management objectives and the available capacity to act (e.g. institutional framework, budget, staff, etc.), and will lead towards a better allocation of resources for fire management operations to achieve specific objectives. One example in achieving an objective of conserving biotic diversity may be the implementation of a patch-mosaic burning system (Brockett et al., 200 1 ) instead of a prescribed block burning system, based on an assumption that the former should better promote biodiversity in the long-term than the latter (Parr & Brockett, 1999). This strategy requires the implementation of early season fires to reduce the size of later season fires. The knowledge of population movements, new settlements or a coming El Nino season, should help focus the resources usage, as these factors might influence the proportion as well as the locations of area burned. Another strategy may be to prioritise the grading of fire lines earlier than usual based on information on high biomass accumulation. However, whatever the strategies, they need to be based on reliable information