Acceleration of convergence of vector sequences

A general approach to the construction of accelerated convergence methods for vector sequences is proposed. A simplified version of minimal polynomial extrapolation is emphasized. The convergence of this method is analyzed and it is shown that it is especially suitable for accelerating the convergence of vector sequences that are obtained when one solves linear systems of equations iteratively

Probability Based Evaluation of Vehicular Bridge Load Using Weigh-in-Motion Data

Load and Resistance Factored Design (LRFD) method for designing bridge in Indonesia have been implemented for more than 25 years. LRFD method treating loads and strengths variables as random variables with specific safety factors for different loads and strengths variables type. The nominal loads, load factors, reduction factors, and other criteria for bridge design code can be determined to meet the reliability criteria. Statistical data of weigh-in-motion (WIM) vehicular loads measurement in Northern Java highway, Cikampek - Pamanukan, West Java (2011), used in as statistical loads variable. A 25 m simple span bridge with reinforced concrete T-girder is used as a model for structural analysis due to WIM measured and nominal vehicular load based on RSNI T-02-2005, with applied bending moment of girder as the output. The distribution fitting result of applied bending moment due to WIM measured vehicular loads is lognormal. The maximum bending moment due to RSNI T-02-2005 nominal vehicular load is 842.45 kN-m and has probability of exceedance of 5x10-5. It can be concluded, for this study, that the bridge designed using RSNI T-02-2005 is safely designed, since it has reliability index, β of 5.02, higher than target reliability, β ranging from 3.50 or 3.72

Upsilon Dissociation in Quark-Gluon Plasma

I consider the dissociation of the upsilon meson due to absorption of a thermal gluon. I discuss the dissociation rate in terms of the energy density, the number density, and the temperature of the quark-gluon plasma. I compare this to the effect due to screening.Comment: 5 pages, added calculations on screening; added figur

Necessary Optimality Conditions for a Dead Oil Isotherm Optimal Control Problem

We study a system of nonlinear partial differential equations resulting from the traditional modelling of oil engineering within the framework of the mechanics of a continuous medium. Recent results on the problem provide existence, uniqueness and regularity of the optimal solution. Here we obtain the first necessary optimality conditions.Comment: 9 page

Optimalisasi Kepadatan Benih Ikan Mas (Cyprinus Carpio) Strain Rajadanu Pada Pendederan Di Kolam Air Tenang [Density Optimization of Carp Seed (Cyprinus Carpio) Strain Rajadanu in the Nursery in Calm Pool Water]

National fisheries production is not proportional to the increase of the population now, so that the consumption of animal protein needs are not met.For the sake of national fisheries production there is a need for intensive cultivation technology breakthroughs to spur the density in nursery phase ‘rajadanu' carp (Cyprinus carpio) strain. This experiment aim to determine the appropriate density of rajadanu carp growth in the pond at the nursery phase. The average length of tested fishes is 2.02 cm and the average initial weight is 0.25 g maintained in the out door plot pool of Research Installation for Germ Plasm of the Research and Development Division of Freshwater Fisheries, Cijeruk, Bogor measuring 1x1x1 m with density 100, 150 and 200 fishes/m3 .Each treatment was repeated 3 times. Feed used was a commercial feed containing 28% protein given in 2 times a day as much as 5% of the total weight of fish. The results showed that after 40 days, each treatment showed no significant difference (P> 0.05) with absolute length and weight growth of the absolute highest in nursery density of 200 fishes/m3 of 1.30 ± 0.10 cm and 1.14 ± 0, 18 cm with a daily growth rate of 1.30 ± 0.10% and 4.08 ± 0.55%, and the highest survival at densities 200 fishes/m3 of 92.5 ± 6.55%

RISK ASSESSMENT OF OPEN PIT SLOPE DESIGN AT PT ADARO INDONESIA

Risk assessment of open pit slope stability is an important aspect to be considered in a decision making of slope design. The risk of slope failure that occurred on the slopes of the mine affect two factors namely the failure probability (FP), and consequences (C) of slope failure. FP is obtained from the collection of the value of Safety Factor (SF) < 1 compared to the total value of SF, while the consequences is estimated from the sectional area multiplied by the width of slope failure. Physical and mechanical properties of sandstone was collected from PT Adaro Indonesia, and tested by “Kolmogorov-Smirnov (K-S)” fitting method to obtain an assumed theoretical distribution that be sued with the character of the original distribution data. “Monte Carlo (MC)” and “Latin Hy- percube (LH)” sampling method is used as a tool to generate sample data, and both methods were compared. Finally Validation is conducted in order to propose an acceptable criteria of FP for single slope of sandstone

CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors

<p>Abstract</p> <p>Background</p> <p>DNA repair deficient tumor cells have been shown to accumulate high levels of DNA damage. Consequently, these cells become hyper-dependent on DNA damage response pathways, including the CHK1-kinase-mediated response. These observations suggest that DNA repair deficient tumors should exhibit increased sensitivity to CHK1 inhibition. Here we offer experimental evidence in support of this hypothesis.</p> <p>Results</p> <p>Using isogenic pairs of cell lines differing only in the Fanconi Anemia (FA) DNA repair pathway, we showed that FA deficient cell lines were hypersensitive to <it>CHK1 </it>silencing by independent siRNAs as well as CHK1 pharmacologic inhibition by Gö6976 and UCN-01. In parallel, an siRNA screen designed to identify gene silencings synthetically lethal with CHK1 inhibition identified genes required for FA pathway function. To confirm these findings <it>in vivo</it>, we demonstrated that whole zebrafish embryos, depleted for <it>FANCD2 </it>by a morpholino approach, were hypersensitive to Gö6976. Silencing of FA genes led to hyper-activation of CHK1 and vice versa. Furthermore, inactivation of CHK1 in FA deficient cell lines caused increased accumulation of DNA strand and chromosomal breakages. These results suggest that the functions subserved by CHK1 and the FA pathway mutually compensate in maintaining genome integrity. As CHK1 inhibition has been under clinical trial in combination with cisplatin, we showed that the FA specific tumoricidal effect of CHK1 inhibition and cisplatin was synergistic.</p> <p>Conclusion</p> <p>Taken together, these results suggest CHK1 inhibition as a strategy for targeting FA deficient tumors.</p