Iranian Americans and the MMPI-2: considering cultural factors in the assessment of psychopathology

Psychological assessment is essential for the purposes of diagnosis and case conceptualization, design and implementation of therapeutic interventions, and referral decisions for adjunctive services. The development of assessment tools that are culturally appropriate and meet the needs of diverse ethnic groups within the United States are necessary to ensure clinical decisions are made with data that are culturally valid for these groups. Of specific interest in this dissertation is the Iranian-American population, which has grown substantially in the United States over the last two decades. The Minnesota Multiphasic Personality Inventory (MMPI-2) is one of the most commonly used assessment tools utilized by psychologists in measuring psychopathology. In spite of its wide use, little is known about the appropriateness of the MMPI-2 with the Iranian-American population. This descriptive study involved a correlational design that investigated the extent to which demographic factors and/or the level of acculturation of Iranian American participants corresponded with variations in scores on the validity and clinical scales of the MMPI-2. Significant differences from the standardization sample of the MMPI-2 validity and clinical scales were analyzed. It was found that those Iranian Americans who were less acculturated to U.S. culture performed higher on scale L, 2, and 0 of the MMPI-2 Interpretations of these scales by mental health professionals should be done so with caution. Iranian specific cultural phenomena such as the practice of tarrof, Iranian dysphoric affect, and the process of immigration should be used to help understand MMPI-2 findings where possible

Growth pattern and daily growth increment in lanternfish (Benthosema pterotum) of the Oman Sea

Lanternfish (Benthosema pterptum) is one of the most important fish species in the Oman Sea. We randomly sampled 300 myctophids from different depths in spring and winter 2009 in the Oman Sea using mid-water trawls. Male to female sex ratio was 0.36:0.64. The thin sections (60-80µm) of sagitta otoliths of the fish were prepared using polishing method. These sections showed that increment growth rings of lanternfish otolith are formed daily and the age condition is distinguishable on a daily basis. We found the life span of the species to be short (with a maximum of 349 micro-increments counted) and probably less than a year. The relationship between standard length (SL) and daily growth increment (D) was expressed as the linear equation: SL=0.87D+12.37 (R 2=0.97). The relationship between lanternfish weight (W) and daily growth increment (D) was expressed as power equation: W=0.00003D1.754 (R2=0.95). Furthermore, morphometrical characteristics of otolith including otolith weight and length and daily growth increment relationships were expressed as linear equation (R2=0.96 and R 2=0.83). The results showed that lanternfish growth rate were in the range 0.241mm/d-1 to 0.138mm/d-1 and decreased by body size and age in this range

Cognitive Skills for Critical Thinking and Second-Language Academic Writing

Critical thinking (CT) includes cognitive skills such as inference, analysis, interpretation, evaluation, explanation, and self-regulation. Previous studies did not pay much attention to CT cognitive skills although they underlie the successful writing in an academic setting. Thus, the present study aimed to investigate the impact of CT cognitive skills on the academic writing of second language learners of Japanese (JSL). Fifty-four JSL learners were randomly divided into three groups: the critical thinking group (CT), the academic writing group (AW), and the control group (CG). Participants in the CT group received an essay writing instruction focused on CT cognitive skills. The participants in the AW group received conventional essay writing instructions. The participants in CG received no instruction. All participants wrote an argumentative essay. Using an analytical academic writing rubric, two raters evaluated the essays in terms of overall quality and the specific components of content, organization, and coherence. The results show that the participants in the CT group had significantly higher scores for overall quality as well as each of the specific components compared with the other two groups. This finding suggests that CT cognitive skills play a critical role in enhancing text quality

第二言語としての日本語のアカデミック・ライティングにおけるプランニング・ストラテジーとクリティカル・シンキングの効果の検証

内容の要約広島大学(Hiroshima University)博士(教育学)Doctor of Philosophy in Educationdoctora

Study of NGEP expression in androgen sensitive prostate cancer cells: A potential target for immunotherapy

Background: Prostate cancer is one of the leading causes of cancer deaths among men. New gene expressed in prostate (NGEP), is a prostate-specific gene expressed only in normal prostate and prostate cancer tissue. Because of its selective expression in prostate cancer cell surface, NGEP is a potential immunotherapeutic target. To target the NGEP in prostate cancer, it is essential to investigate its expression in prostate cancer cells. Methods: In the present study, we investigated NGEP expression in LNCaP and DU145 cells by real time and RT-PCR, flow cytometric and immunocytochemical analyses. Results: Real time and RT-PCR analyses of NGEP expression showed that NGEP was expressed in the LNCaP cells but not in DU145 cells. The detection of NGEP protein by flow cytometric and immunocytochemistry analyses indicated that NGEP protein was weakly expressed only in LNCaP cell membrane. Conclusion: Our results demonstrate that LNCaP cell line is more suitable than DU145 for NGEP expression studies; however, its low-level expression is a limiting issue. NGEP expression may be increased by androgen supplementation of LNCaP cell culture medium

Evaluation of diagnostic value of soluble urokinase-type plasminogen activator receptor in sepsis

Background: Sepsis is one of the most important causes of morbidity and mortality in the intensive care units (ICUs). It is difficult to accurately differentiate sepsis from similar diseases rapidly. Therefore, it becomes critical to identify any biomarker with the ability of differentiation between sepsis and nonsepsis conditions. The urokinase plasminogen activator receptor has been implicated as an important factor in regulation of leukocyte adhesion and migration. Objectives: In this study, we evaluated the value of soluble urokinase plasminogen activator receptor (suPAR), erythrocyte sedimentation (ESR), and C-reactive protein (CRP) serum levels in terms of their value for sepsis diagnosis in ICU patients. Patients and Methods: We enrolled 107 ICU patients; 40 with sepsis, 43 with systemic inflammatory response syndrome, and 24 as control group. Serum soluble urokinase plasminogen activator receptor, ESR, white blood cell (WBC), and CRP levels were measured on the day of admission. Results: The group with sepsis had higher suPAR, ESR, and CRP levels compared with the group with noninfectious systemic inflammatory response syndrome (SIRS) (P = 0.01, 0.00 and 0.00, respectively). CRP concentrations and ESR were higher in the sepsis group than in the non-SIRS group (P = 0.00 and 0.00, respectively). In a receiver-operating characteristic curve analysis, ESR, CRP and suPAR had an area under the curve larger than 0.65 (P = 0.00) in distinguishing between septic and noninfectious SIRS patients. CRP, ESR and suPAR had a sensitivity of 87, 71 and 66 and a specificity of 59, 76 and 74 respectively in diagnosing infection in SIRS. Conclusions: The diagnostic values of CRP and ESR were better than suPAR and WBC count in patients with sepsis. © 2015, Infectious Diseases and Tropical Medicine Research Center

Leveraging unique structural characteristics of WNK kinases to achieve therapeutic inhibition

This is the author accepted manuscript. The final version is available from American Association for the Advancement of Science via the DOI in this record.The with-no-lysine (K) WNK kinases are master regulators of the Na+-(K+)-Cl- cotransporters, including the renal-specific NCC and NKCC2 cotransporters. The discovery of WNK463, an orally bioavailable pan-WNK kinase inhibitor that exploits unique structural properties of the WNK catalytic domain to achieve high affinity and kinase selectivity, illustrates a strategy of leveraging distinct kinase features to develop specific inhibitors and validates the genetic predictions of the in vivo pharmacology of WNK inhibition

Clinical learning environments (actual and expected): Perceptions of Iran University of Medical Sciences nursing students

Background: Educational clinical environment has an important role in nursing students' learning. Any difference between actual and expected clinical environment will decrease nursing students' interest in clinical environments and has a negative correlation with their clinical performance. Methods: This descriptive cross-sectional study is an attempt to compare nursing students' perception of the actual and expected status of clinical environments in medical-surgical wards. Participants of the study were 127 bachelor nursing students of Iran University of Medical Sciences in the internship period. Data gathering instruments were a demographic questionnaire (including sex, age, and grade point average), and the Clinical Learning Environment Inventory (CLEI) originally developed by Professor Chan (2001), in which its modified Farsi version (Actual and Preferred forms) consisting 42 items, 6 scales and 7 items per scale was used. Descriptive and inferential statistics (t-test, paired t-test, ANOVA) were used for data analysis through SPSS version 16. Results: The results indicated that there were significant differences between the preferred and actual form in all six scales. In other word, comparing with the actual form, the mean scores of all items in the preferred form were higher. The maximum mean difference was in innovation and the highest mean difference was in involvement scale. Conclusion: It is concluded that nursing students do not have a positive perception of their actual clinical teaching environment and this perception is significantly different from their perception of their expected environment

WNK Kinase Signaling in Ion Homeostasis and Human Disease

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.WNK kinases, along with their upstream regulators (CUL3/KLHL3) and downstream targets (the SPAK/OSR1 kinases and the cation-Cl- cotransporters [CCCs]), comprise a signaling cascade essential for ion homeostasis in the kidney and nervous system. Recent work has furthered our understanding of the WNKs in epithelial transport, cell volume homeostasis, and GABA signaling, and uncovered novel roles for this pathway in immune cell function and cell proliferation.This work was supported by a NIHNRCDP grant (K.T.K.), Simons Foundation grant #400947 (K.T.K.), March of Dimes Basil O’Connor Award (K.T.K.), and NIH grant DK93501 to E.D