'I Heard Beauty Dying': The Cultural Critique of Plastic in Gravity's Rainbow

This essay attempts to get a grasp on Pynchon's 700-plus page omnibus, Gravity's Rainbow, by focusing on the development of a single motif in the novel: plastic. It argues that Pynchon takes 1960s and 1970s critiques of supply-driven consumer capitalism, of which plastic was a visible emblem, and makes them more emphatic by placing them into a fictionalized version of the prewar years and the 1940s. Looking backwards, and employing a creative license that allows him to attribute the rise of plastics technology and consumer capitalism to purposely evil entities (like his fictional versions of real-life corporations IG Farben and Shell Oil), Pynchon is able to deliver a narrative that locates the roots of contemporary problems in the technological and business innovations of the World War II era. In Gravity's Rainbow, as in early-'70s America, plastic comes to signify for a suite of negative meanings, from environmental degradation, to an exploitative economic order, to a sadistic psychology in which the desire to achieve immortality results in the destruction and perversion of life itself. The essay is divided into three sections. The first uses a cultural history of plastic to identify popular cultural attitudes towards plastic and locate them in Pynchon's text. The second turns towards a closer reading of Gravity's Rainbow, examining the character Greta Erdmann and her relationship to plastic. The final section considers a second character, Tyrone Slothrop, and concludes that Pynchon's critique of plastic ends on a pessimistic note, positing only a limited possibility for meaningful resistance towards plastic and the material and psychological economies that it represents

Black ceiling tiles reduce occupational UV exposure for staff in clinical area containing phototherapy cabinets

Phototherapy clinics administer UV light to patients via phototherapy cabinets. The UV radiation from these cabinets reflects on the white ceiling tiles of the clinic and is directed towards both staff and patients in the area. This is particularly problematic for clinical technologists who must undertake dosimetry in these areas and have a particular time (often as low as 30 minutes) before they reach their maximum exposure limit. By replacing the white tiles with black alternatives which absorb the stray radiation, we have been able to reduce these reflections by almost 90%, prolonging the time to maximum exposure by nearly 10 times. We therefore present these findings to encourage similar clinics to undertake the simple protocols outlined which will significantly improve staff and patient safety.</p

Black ceiling tiles reduce occupational UV exposure for staff in clinical area containing phototherapy cabinets

Phototherapy clinics administer UV light to patients via phototherapy cabinets. The UV radiation from these cabinets reflects on the white ceiling tiles of the clinic and is directed towards both staff and patients in the area. This is particularly problematic for clinical technologists who must undertake dosimetry in these areas and have a particular time (often as low as 30 minutes) before they reach their maximum exposure limit. By replacing the white tiles with black alternatives which absorb the stray radiation, we have been able to reduce these reflections by almost 90%, prolonging the time to maximum exposure by nearly 10 times. We therefore present these findings to encourage similar clinics to undertake the simple protocols outlined which will significantly improve staff and patient safety.</p

Improving living and dying for people with advanced dementia living in care homes: a realist review of Namaste Care and other multisensory interventions

© The Author(s). 2018Background: Seventy percent of people with advanced dementia live and die in care homes. Multisensory approaches, such as Namaste Care, have been developed to improve the quality of life and dying for people with advanced dementia but little is known about effectiveness or optimum delivery. The aim of this review was to develop an explanatory account of how the Namaste Care intervention might work, on what outcomes, and in what circumstances. Methods: This is a realist review involving scoping of the literature and stakeholder interviews to develop theoretical explanations of how interventions might work, systematic searches of the evidence to test and develop the theories, and their validation with a purposive sample of stakeholders. Twenty stakeholders - user/patient representatives, dementia care providers, care home staff, researchers -took part in interviews and/or workshops. Results: We included 85 papers. Eight focused on Namaste Care and the remainder on other types of sensory interventions such as music therapy or massage. We identified three context-mechanism-outcome configurations which together provide an explanatory account of what needs to be in place for Namaste Care to work for people living with advanced dementia. This includes: providing structured access to social and physical stimulation, equipping care home staff to cope effectively with complex behaviours and variable responses, and providing a framework for person-centred care. A key overarching theme concerned the importance of activities that enabled the development of moments of connection for people with advanced dementia. Conclusions: This realist review provides a coherent account of how Namaste Care, and other multisensory interventions might work. It provides practitioners and researchers with a framework to judge the feasibility and likely success of Namaste Care in long term settings. Key for staff and residents is that the intervention triggers feelings of familiarity, reassurance, engagement and connection.Peer reviewe

What is Missing from the Local Stellar Halo?

The Milky Way's stellar halo, which extends to $>100$ kpc, encodes the evolutionary history of our Galaxy. However, most studies of the halo to date have been limited to within a few kpc of the Sun. Here, we characterize differences between this local halo and the stellar halo in its entirety. We construct a composite stellar halo model by combining observationally motivated N-body simulations of the Milky Way's nine most massive disrupted dwarf galaxies that account for almost all of the mass in the halo. We find that (1) the representation by mass of different dwarf galaxies in the local halo compared to the whole halo can be significantly overestimated (e.g., the Helmi Streams) or underestimated (e.g., Cetus) and (2) properties of the overall halo (e.g., net rotation) inferred via orbit integration of local halo stars are significantly biased, because e.g., highly retrograde debris from Gaia-Sausage-Enceladus is missing from the local halo. Therefore, extrapolations from the local to the global halo should be treated with caution. From analysis of a sample of 11 MW-like simulated halos, we identify a population of recently accreted ($\lesssim5$ Gyrs) and disrupted galaxies on high angular momenta orbits that are entirely missing from local samples, and awaiting discovery in the outer halo. Our results motivate the need for surveys of halo stars extending to the Galaxy's virial radius.Comment: 12 pages, 6 figures. Submitted to ApJ. Comments warmly welcome

Distance Education of Pennsylvania Pond Owners

Pennsylvania pond owners represent a large audience with a great need for educational programming and assistance. Penn State Extension attempted to reach this audience via a pond management program delivered by satellite. Evaluations by both program attendees and Extension professionals demonstrated that the program was successful. However, attendee respondents indicated that they wanted more in-depth information over a shorter time frame. A relatively small proportion (10%) of attendees did not favor satellite delivery. This level of dissatisfaction is quite low and may be improved by focusing on shorter, more focused satellite programs and by providing videotapes of satellite programs

Understanding microbial ecology to improve management of drinking water distribution systems

Microorganisms in Drinking Water Distribution Systems (DWDS) and in particular the microbial communities that form biofilms on infrastructure surfaces, drive critical processes impacting water quality. This paper reviews knowledge, research approaches and monitoring methods to consolidate understanding of the microbial ecology of DWDS. The review highlights how microbial characteristics and subsequent behaviour can be broadly classified as common or complex. Common behaviour relates to the ubiquitous and continual development of biofilms, consistent core communities and mediated material accumulation. In contrast, the complex aspect relates to the shape, structure and composition of the microbiome, defined by site specific properties such as supplied source water, pipe material and hydraulic regimes. It is shown how the latest microbial tools and techniques can be applied to increase our understanding of DWDS ecology and how water utilities are starting to use this knowledge. This is not because of regulatory requirements, but in recognition that they provide valuable information facilitating pro-active management and operation benefits to these critical yet ageing systems, protecting water quality and public health in the process

Effects of prenatal exposure to xenobiotic estrogen and the development of endometriosis in adulthood

Abstract only availableEndometriosis is an estrogen-dependent disease that affects millions of women worldwide, causing pain and infertility. While it is known that retrograde menstruation places endometrial tissue in the peritoneal cavity, it is unclear why it invades and proliferates in women with endometriosis. Studies have shown that other hormone-dependent diseases have a fetal basis (e.g. breast cancer), suggesting that the presence of different hormones before birth may alter the incidence of endometriosis in adulthood. For example, women whose mothers took the synthetic estrogen diethylstilbestrol (DES) during pregnancy had an eighty percent increased incidence of endometriosis. Thus, our hypothesis is that prenatal exposure to xenobiotic estrogen will increase the severity of endometriosis in adulthood in a mouse model of surgically-induced endometriosis. To test this hypothesis, mice were time mated and dosed with vehicle control, 100 ng/kg DES or 10,000 ng/kg DES from days 11-17 of gestation. Surgical induction of endometriosis was performed in adulthood by autotransplantation of one uterine horm. The horn was removed, opened, divided into three pieces, and sutured to the arterial cascade of the intestinal mesentery. The implants became vascularized and formed endometriotic lesions. The mice were then collected at 2 or 4 weeks post-surgery, and the following endpoints were measured: 1) uterine weight; 2) implant size; and 3) implant weight. Additionally, implants were set aside for further analysis of 1) histology; 2) estrogen receptor indicator reporter gene activity; and 3) endometriosis-related gene expression. At the conclusion of this ongoing study, we expect to show whether there is an estrogen-mediated fetal component to endometriosis.Life Sciences Undergraduate Research Opportunity Progra

Neonatal exposure to xenobiotic estrogen alters the adult immune response and exacerbates endometriosis in mice [abstract]

Faculty Mentor: Dr. Susan C. Nagel, Obstetrics/Gynecology, and Women's HealthAbstract only availableEndometriosis is a common medical condition affecting 5-10% of women worldwide, and results in severe cramps, pelvic pain, and infertility. The cause of the disease is still unknown. Endometriosis occurs when endometrial tissue, which escapes into the peritoneal cavity via retrograde menstruation, adheres to other tissues in the cavity and causes irritated, inflamed lesions. Studies have suggested that the risk of developing endometriosis increases in women who have been exposed to xenobiotic (foreign to the body) estrogens during developmental stages of life. Thus, it is our hypothesis that programming of the immune system by xenoestrogens during development could potentially exacerbate endometriosis. This could occur by altering the peritoneal environment and/or the invading endometrial tissue. Therefore, it is our goal to study the effects of neonatal xenoestrogen exposure on the immune system; and ultimately, on the establishment of endometriosis in adulthood. In order to study this response, we dosed two strains of mice (CD1 and C57) with xenobiotic estrogens on postnatal days 2-14. In experiment A, CD1 mice were dosed with vehicle control (corn oil), 20 µg/kg/day, or 200 µg/kg/day bisphenol A. In experiment B, C57 mice were dosed with a vehicle control (corn oil) or 0.1 µg/kg/day diethylstilbestrol. At 8 weeks of age, endometriosis was induced in each strain via both a surgical induction and an injection technique. At 12 weeks, the endometriotic implants were counted and weighed to determine which mice had a greater susceptibility to the condition. Our next objective will be to analyze peritoneal fluid from the treated mice to identify key immune functions (for example, the release of certain cytokines) that may have been programmed by developmental xenoestrogen exposure.Endometriosis is a common medical condition affecting 5-10% of women worldwide, and results in severe cramps, pelvic pain, and infertility.  The cause of the disease is still unknown.  Endometriosis occurs when endometrial tissue, which escapes into the peritoneal cavity via retrograde menstruation, adheres to other tissues in the cavity and causes irritated, inflamed lesions.  Studies have suggested that the risk of developing endometriosis increases in women who have been exposed to xenobiotic (foreign to the body) estrogens during developmental stages of life.  Thus, it is our hypothesis that programming of the immune system by xenoestrogens during development could potentially exacerbate endometriosis.  This could occur by altering the peritoneal environment and/or the invading endometrial tissue.  Therefore, it is our goal to study the effects of neonatal xenoestrogen exposure on the immune system; and ultimately, on the establishment of endometriosis in adulthood.  In order to study this response, we dosed two strains of mice (CD1 and C57) with xenobiotic estrogens on postnatal days 2-14.  In experiment A, CD1 mice were dosed with vehicle control (corn oil), 20 µg/kg/day, or 200 µg/kg/day bisphenol A.  In experiment B, C57 mice were dosed with a vehicle control (corn oil) or 0.1 µg/kg/day diethylstilbestrol.  At 8 weeks of age, endometriosis was induced in each strain via both a surgical induction and an injection technique.  At 12 weeks, the endometriotic implants were counted and weighed to determine which mice had a greater susceptibility to the condition.  Our next objective will be to analyze peritoneal fluid from the treated mice to identify key immune functions (for example, the release of certain cytokines) that may have been programmed by developmental xenoestrogen exposure

Exploiting embedded intelligence in manufacturing decision support

Exploiting embedded intelligence in manufacturing decision suppor