93 research outputs found
The image of the Crimean Tatars in Jewish chronicles of the Khmelnytsky period
Introduction. The purpose of the article is a detailed analysis of the assessments contained in the Jewish historical chronicles of the Khmelnytsky uprising period and related to the characteristics of the Crimean Tatars who took an active part in the uprising of B.M. Khmelnitsky. Based on these assessments, we can reconstruct the image of the Muslim Tatars that developed in the historical consciousness of the Jewish late medieval society under the influence of the experienced catastrophe. Methods. Since the peculiarity of this study is the exceptional attention to the text of the source, methods based on text analysis and methods based on contextual analysis of speech and semantic constructions used by Jewish publicists and comparing them with the facts of biographies and historical events that could possibly affect the texts of chronicles were widely used. To solve the tasks set in the work, such concrete historical methods as historical-comparative and historicaltypological were also used. Results. On the basis of the work done, it can be concluded that for Jewish authors – creators of historical chronicles of the period of the «Khmelnichiny», the Muslim Tatars act, though evil, but much less than the evil that the Orthodox Ukrainians carried to the Jewish population. In the image of the Crimean Tatars, to some extent, one can even find positive assessments showing pity and concern for those Jews who surrendered to them. The same cannot be said about the image of the Orthodox population that has developed in Jewish chronicles under the impression of the horrors of the People's Liberation war in Ukraine in the middle of the XVII century. Conclusion. The Crimean Tatars who took part in the uprising of Bohdan Khmelnytsky were perceived by Jews as enemies, but with a certain shade of respect, which we absolutely will not find in the current image of the Orthodox population of Ukraine
Association of mitochondrial lysyl-tRNA synthetase with HIV-1 GagPol involves catalytic domain of the synthetase and transframe and integrase domains of Pol
Aim. Analyze the interaction between Lysyl-tRNA synthetase (LysRS) and HIV-1 GagPol to know whether a particular N-terminal sequence of mitochondrial LysRS triggers a specific recognition with GagPol. Methods.
Yeast two-hybrid analysis, immunoprecipitation. Results. We have shown that LysRS associates with the Pol domain of GagPol. Conclusions. A model of the assembly of the LysRS:tRNA₃Lys:GagPol packaging complex is
proposed.
Keywords: tRNA₃Lys, lysyl-tRNA synthetase, HIV-1, packaging.Мета. Встановити, чи може N-кінцева послідовність, яка є специфічною для мітохондріальної форми лізил-тРНК синтетази,
забезпечувати взаємодію цього ферменту з білком GagPol ВІЛ-1.
Методи. Двогібридна дріжджова система, імунопреципітація.
Результати. Ми показали що лізил-тРНК синтетаза взаємодіє з
доменом Pol білка Gag. Висновки. Запропоновано модель утворення комплексу ЛізРС:тРНК₃Ліз:GagPol.
Ключові слова: тРНК₃Ліз, лізил-тРНК синтетаза, ВІЛ-1, збирання віріона.Цель. Выяснить, может ли N-концевая последовательность, являющаяся специфичной для митохондриальной формы лизилтРНК синтетазы, обеспечивать взаимодействие этого фермента с белком GagPol ВИЧ-1. Методы. Двугибридная дрожжевая
система, иммунопреципитация Результаты. Мы показали, что
лизил-тРНК синтетаза взаимодействует с доменом Pol белка
Gag. Выводы. Предложена модель образования комплекса ЛизРС:тРНК₃Лиз:GagPol.
Ключевые слова: тРНК₃Лиз, лизил-тРНК синтетаза, ВИЧ-1,
сборка вириона
ВЛИЯНИЕ ЙОДСОДЕРЖАЩЕГО ПРЕПАРАТА «ЙОДОМАРИН» НА ВОСПРОИЗВОДИТЕЛЬНУЮ СПОСОБНОСТЬ И МОЛОЧНУЮ ПРОДУКТИВНОСТЬ КОРОВ
The influence of the new iodine containing preparation Iodomarin on the reproductive capacity and lactation performance of cows has been studied. It’s established that the use of 750 mkg of Iodomarin per capita a day improves the reproductive capacity of cows. It is reflected in the reduction of the labour length, a quicker separation of the placenta after calving, the reduction of the service time, and the increase of the lactation performance.Изучено влияние нового йодсодержащего препарата «Йодомарин» на воспроизводительную способность и молочную продуктивность коров. Установлено, что использование для коров сухостойного периода препарата «Йодомарин» в количестве 750 мкг на голову в сутки способствует улучшению воспроизводительной способности коров, что проявляется в сокращении продолжительности родов, более быстром отделении последа после отела, сокращении сервис-периода, а также повышению молочной продуктивности
Prevalence and etiology of false normal aEEG recordings in neonatal hypoxic-ischaemic encephalopathy.
BACKGROUND: Amplitude-integrated electroencephalography (aEEG) is a useful tool to determine the severity of neonatal hypoxic-ischemic encephalopathy (HIE). Our aim was to assess the prevalence and study the origin of false normal aEEG recordings based on 85 aEEG recordings registered before six hours of age. METHODS: Raw EEG recordings were reevaluated retrospectively with Fourier analysis to identify and describe the frequency patterns of the raw EEG signal, in cases with inconsistent aEEG recordings and clinical symptoms. Power spectral density curves, power (P) and median frequency (MF) were determined using the raw EEG. In 7 patients non-depolarizing muscle relaxant (NDMR) exposure was found. The EEG sections were analyzed and compared before and after NDMR administration. RESULTS: The reevaluation found that the aEEG was truly normal in 4 neonates. In 3 neonates, high voltage electrocardiographic (ECG) artifacts were found with flat trace on raw EEG. High frequency component (HFC) was found as a cause of normal appearing aEEG in 10 neonates. HFC disappeared while P and MF decreased significantly upon NDMR administration in each observed case. CONCLUSION: Occurrence of false normal aEEG background pattern is relatively high in neonates with HIE and hypothermia. High frequency EEG artifacts suggestive of shivering were found to be the most common cause of false normal aEEG in hypothermic neonates while high voltage ECG artifacts are less common
Morphological and immunohistochemical analysis of apoptosis in the cerebellum of rats subjected to focal cerebral ischemia with or without alcoholism model
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Mother-infant interactions and regional brain volumes in infancy: an MRI study
Background: It is generally agreed that the human brain is responsive to environmental influences, and that the male brain may be particularly sensitive to early adversity. However, this is largely based on retrospective studies of older children and adolescents exposed to extreme environments in childhood. Less is understood about how normative variations in parent-child interactions are associated with the development of the infant brain in typical settings.
Method: To address this, we used magnetic resonance imaging to investigate the relationship between observational measures of mother-infant interactions and regional brain volumes in a community sample of 3-6 month old infants (N=39). In addition, we examined whether this relationship differed in male and female infants.
Results: We found that lower maternal sensitivity was correlated with smaller subcortical grey matter volumes in the whole sample, and that this was similar in both sexes. However, male infants who showed greater levels of positive communication and engagement during early interactions had smaller cerebellar volumes.
Conclusion These preliminary findings suggest that variations in mother-infant interaction dimensions are associated with differences in infant brain development. Although the study is cross-sectional and causation cannot be inferred, the findings reveal a dynamic interaction between brain and environment that may be important when considering interventions to optimize infant outcomes
Entamoeba lysyl-tRNA Synthetase Contains a Cytokine-Like Domain with Chemokine Activity towards Human Endothelial Cells
Immunological pressure encountered by protozoan parasites drives the selection of strategies to modulate or avoid the immune responses of their hosts. Here we show that the parasite Entamoeba histolytica has evolved a chemokine that mimics the sequence, structure, and function of the human cytokine HsEMAPII (Homo sapiens endothelial monocyte activating polypeptide II). This Entamoeba EMAPII-like polypeptide (EELP) is translated as a domain attached to two different aminoacyl-tRNA synthetases (aaRS) that are overexpressed when parasites are exposed to inflammatory signals. EELP is dispensable for the tRNA aminoacylation activity of the enzymes that harbor it, and it is cleaved from them by Entamoeba proteases to generate a standalone cytokine. Isolated EELP acts as a chemoattractant for human cells, but its cell specificity is different from that of HsEMAPII. We show that cell specificity differences between HsEMAPII and EELP can be swapped by site directed mutagenesis of only two residues in the cytokines' signal sequence. Thus, Entamoeba has evolved a functional mimic of an aaRS-associated human cytokine with modified cell specificity
Effect of Systemic Hypertension With Versus Without Left Ventricular Hypertrophy on the Progression of Atrial Fibrillation (from the Euro Heart Survey).
Hypertension is a risk factor for both progression of atrial fibrillation (AF) and development of AF-related complications, that is major adverse cardiac and cerebrovascular events (MACCE). It is unknown whether left ventricular hypertrophy (LVH) as a consequence of hypertension is also a risk factor for both these end points. We aimed to assess this in low-risk AF patients, also assessing gender-related differences. We included 799 patients from the Euro Heart Survey with nonvalvular AF and a baseline echocardiogram. Patients with and without hypertension were included. End points after 1 year were occurrence of AF progression, that is paroxysmal AF becoming persistent and/or permanent AF, and MACCE. Echocardiographic LVH was present in 33% of 379 hypertensive patients. AF progression after 1 year occurred in 10.2% of 373 patients with rhythm follow-up. In hypertensive patients with LVH, AF progression occurred more frequently as compared with hypertensive patients without LVH (23.3% vs 8.8%, p = 0.011). In hypertensive AF patients, LVH was the most important multivariably adjusted determinant of AF progression on multivariable logistic regression (odds ratio 4.84, 95% confidence interval 1.70 to 13.78, p = 0.003). This effect was only seen in male patients (27.5% vs 5.8%, p = 0.002), while in female hypertensive patients, no differences were found in AF progression rates regarding the presence or absence of LVH (15.2% vs 15.0%, p = 0.999). No differences were seen in MACCE for hypertensive patients with and without LVH. In conclusion, in men with hypertension, LVH is associated with AF progression. This association seems to be absent in hypertensive women
Progression From Paroxysmal to Persistent Atrial Fibrillation. Clinical Correlates and Prognosis
Objectives: We investigated clinical correlates of atrial fibrillation (AF) progression and evaluated the prognosis of patients demonstrating AF progression in a large population. Background: Progression of paroxysmal AF to more sustained forms is frequently seen. However, not all patients will progress to persistent AF. Methods: We included 1,219 patients with paroxysmal AF who participated in the Euro Heart Survey on AF and had a known rhythm status at follow-up. Patients who experienced AF progression after 1 year of follow-up were identified. Results: Progression of AF occurred in 178 (15%) patients. Multivariate analysis showed that heart failure, age, previous transient ischemic attack or stroke, chronic obstructive pulmonary disease, and hypertension were the only independent predictors of AF progression. Using the regression coefficient as a benchmark, we calculated the HATCH score. Nearly 50% of the patients with a HATCH score >5 progressed to persistent AF compared with only 6% of the patients with a HATCH score of 0. During follow-up, patients with AF progression were more often admitted to the hospital and had more major adverse cardiovascular events. Conclusions: A substantial number of patients progress to sustained AF within 1 year. The clinical outcome of these patients regarding hospital admissions and major adverse cardiovascular events was worse compared with patients demonstrating no AF progression. Factors known to cause atrial structural remodeling (age and underlying heart disease) were independent predictors of AF progression. The HATCH score may help to identify patients who are likely to progress to sustained forms of AF in the near future. \ua9 2010 American College of Cardiology Foundation
Maternal infection and risk of intrapartum death: a population based observational study in South Asia
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