Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.

Thyroid dysfunction is an important public health problem, which affects 10% of the general population and increases the risk of cardiovascular morbidity and mortality. Many aspects of thyroid hormone regulation have only partly been elucidated, including its transport, metabolism, and genetic determinants. Here we report a large meta-analysis of genome-wide association studies for thyroid function and dysfunction, testing 8 million genetic variants in up to 72,167 individuals. One-hundred-and-nine independent genetic variants are associated with these traits. A genetic risk score, calculated to assess their combined effects on clinical end points, shows significant associations with increased risk of both overt (Graves' disease) and subclinical thyroid disease, as well as clinical complications. By functional follow-up on selected signals, we identify a novel thyroid hormone transporter (SLC17A4) and a metabolizing enzyme (AADAT). Together, these results provide new knowledge about thyroid hormone physiology and disease, opening new possibilities for therapeutic targets

Niet volgens het boekje. Over drie Nederlandse edellieden die in de periode 1930-1945 kozen voor het nationaal-socialisme

De auteur poogt in deze scriptie aan de hand van korte biografische schetsen na te gaan waarom drie Nederlandse aristocraten kozen voor het nationaal-socialisme. De besproken edellieden zijn Maximiliaan graaf de Marchant et d'Ansembourg, jvr. Julia op ten Noort en dr. Ernst ridder van Rappard. De focus ligt op de jeugd- en jonge jaren van de besproken personen, tot het moment van hun keuze

Geology and geophysics of an area east of the Great Meteor Seamount RRS Discovery cruise 144, 22 January - 20 February 1984

SIGLEAvailable from British Library Lending Division - LD:4565.45(IOS-CR--161) / BLDSC - British Library Document Supply CentreGBUnited Kingdo