767 research outputs found
Stochastic unraveling of Redfield master equations and its application to electron transfer problems
A method for stochastic unraveling of general time-local quantum master
equations (QMEs) is proposed. The present kind of jump algorithm allows a
numerically efficient treatment of QMEs which are not in Lindblad form, i.e.
are not positive semidefinite by definition. The unraveling can be achieved by
allowing for trajectories with negative weights. Such a property is necessary,
e.g. to unravel the Redfield QME and to treat various related problems with
high numerical efficiency. The method is successfully tested on the damped
harmonic oscillator and on electron transfer models including one and two
reaction coordinates. The obtained results are compared to those from a direct
propagation of the reduced density matrix (RDM) as well as from the standard
quantum jump method. Comparison of the numerical efficiency is performed
considering both the population dynamics and the RDM in the Wigner phase space
representation.Comment: accepted in J. Chem. Phys.; 26 pages, 6 figures; the order of
authors' names on the title page correcte
Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.
Acquired drug resistance prevents cancer therapies from achieving stable and complete responses. Emerging evidence implicates a key role for non-mutational drug resistance mechanisms underlying the survival of residual cancer 'persister' cells. The persister cell pool constitutes a reservoir from which drug-resistant tumours may emerge. Targeting persister cells therefore presents a therapeutic opportunity to impede tumour relapse. We previously found that cancer cells in a high mesenchymal therapy-resistant cell state are dependent on the lipid hydroperoxidase GPX4 for survival. Here we show that a similar therapy-resistant cell state underlies the behaviour of persister cells derived from a wide range of cancers and drug treatments. Consequently, we demonstrate that persister cells acquire a dependency on GPX4. Loss of GPX4 function results in selective persister cell ferroptotic death in vitro and prevents tumour relapse in mice. These findings suggest that targeting of GPX4 may represent a therapeutic strategy to prevent acquired drug resistance
Monte-Carlo Simulations of the Dynamical Behavior of the Coulomb Glass
We study the dynamical behavior of disordered many-particle systems with
long-range Coulomb interactions by means of damage-spreading simulations. In
this type of Monte-Carlo simulations one investigates the time evolution of the
damage, i.e. the difference of the occupation numbers of two systems, subjected
to the same thermal noise. We analyze the dependence of the damage on
temperature and disorder strength. For zero disorder the spreading transition
coincides with the equilibrium phase transition, whereas for finite disorder,
we find evidence for a dynamical phase transition well below the transition
temperature of the pure system.Comment: 10 pages RevTeX, 8 Postscript figure
Lung cancer stigma predicts timing of medical help-seeking in individuals with lung cancer
Purpose/Objectives
To examine relationships among demographic variables, healthcare system distrust, lung cancer stigma, smoking status, and timing of medical helpâseeking behavior in individuals with symptoms suggestive of lung cancer after controlling for ethnicity, socioeconomic status, and social desirability.
Design
Descriptive, cross-sectional, correlational study.
Setting
Outpatient oncology clinics in Louisville, KY.
Sample
94 patients diagnosed in the past three weeks to six years with all stages of lung cancer.
Methods
Self-report, written survey packets were administered in person followed by a semistructured interview to assess symptoms and timing characteristics of practice-identified patients with lung cancer.
Main Research Variables
Timing of medical helpâseeking behavior, healthcare system distrust, lung cancer stigma, and smoking status.
Findings
Lung cancer stigma was independently associated with timing of medical helpâseeking behavior in patients with lung cancer. Healthcare system distrust and smoking status were not independently associated with timing of medical helpâseeking behavior.
Conclusions
Findings suggest that stigma influences medical helpâseeking behavior for lung cancer symptoms, serving as a barrier to prompt medical helpâseeking behavior.
Implications for Nursing
When designing interventions to promote early medical helpâseeking behavior in individuals with symptoms suggestive of lung cancer, methods that consider lung cancer stigma as a barrier that can be addressed through public awareness and patient-targeted interventions should be included
Managing FAIR Tribological Data Using Kadi4Mat
The ever-increasing amount of data generated from experiments and simulations in engineering sciences is relying more and more on data science applications to generate new knowledge. Comprehensive metadata descriptions and a suitable research data infrastructure are essential prerequisites for these tasks. Experimental tribology, in particular, presents some unique challenges in this regard due to the interdisciplinary nature of the field and the lack of existing standards. In this work, we demonstrate the versatility of the open source research data infrastructure Kadi4Mat by managing and producing FAIR tribological data. As a showcase example, a tribological experiment is conducted by an experimental group with a focus on comprehensiveness. The result is a FAIR data package containing all produced data as well as machine- and user-readable metadata. The close collaboration between tribologists and software developers shows a practical bottom-up approach and how such infrastructures are an essential part of our FAIR digital future
Differences between regular and random order of updates in damage spreading simulations
We investigate the spreading of damage in the three-dimensional Ising model
by means of large-scale Monte-Carlo simulations. Within the Glauber dynamics we
use different rules for the order in which the sites are updated. We find that
the stationary damage values and the spreading temperature are different for
different update order. In particular, random update order leads to larger
damage and a lower spreading temperature than regular order. Consequently,
damage spreading in the Ising model is non-universal not only with respect to
different update algorithms (e.g. Glauber vs. heat-bath dynamics) as already
known, but even with respect to the order of sites.Comment: final version as published, 4 pages REVTeX, 2 eps figures include
Exact Eigenstates of Tight-Binding Hamiltonians on the Penrose Tiling
We investigate exact eigenstates of tight-binding models on the planar
rhombic Penrose tiling. We consider a vertex model with hopping along the edges
and the diagonals of the rhombi. For the wave functions, we employ an ansatz,
first introduced by Sutherland, which is based on the arrow decoration that
encodes the matching rules of the tiling. Exact eigenstates are constructed for
particular values of the hopping parameters and the eigenenergy. By a
generalized ansatz that exploits the inflation symmetry of the tiling, we show
that the corresponding eigenenergies are infinitely degenerate. Generalizations
and applications to other systems are outlined.Comment: 24 pages, REVTeX, 13 PostScript figures include
Shape Analysis of the Level Spacing Distribution around the Metal Insulator Transition in the Three Dimensional Anderson Model
We present a new method for the numerical treatment of second order phase
transitions using the level spacing distribution function . We show that
the quantities introduced originally for the shape analysis of eigenvectors can
be properly applied for the description of the eigenvalues as well. The
position of the metal--insulator transition (MIT) of the three dimensional
Anderson model and the critical exponent are evaluated. The shape analysis of
obtained numerically shows that near the MIT is clearly different
from both the Brody distribution and from Izrailev's formula, and the best
description is of the form , with
. This is in good agreement with recent analytical results.Comment: 14 pages in plain TeX, 6 figures upon reques
Single spontaneous photon as a coherent beamsplitter for an atomic matterwave
In spontaneous emission an atom in an excited state undergoes a transition to
the ground state and emits a single photon. Associated with the emission is a
change of the atomic momentum due to photon recoil. Photon emission can be
modified close to surfaces and in cavities. For an ion, localized in front of a
mirror, coherence of the emitted resonance fluorescence has been reported. In
free space experiments demonstrated that spontaneous emission destroys motional
coherence. Here we report on motional coherence created by a single spontaneous
emission event close to a mirror surface. The coherence in the free atomic
motion is verified by atom interferometry. The photon can be regarded as a
beamsplitter for an atomic matterwave and consequently our experiment extends
the original recoiling slit Gedanken experiment by Einstein to the case where
the slit is in a robust coherent superposition of the two recoils associated
with the two paths of the quanta.Comment: main text: 5 pages, 4 figure; supplementary information: 8 pages, 1
figur
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